ZIP4_CAEEL
ID ZIP4_CAEEL Reviewed; 318 AA.
AC H2L0N3; G4SR45; Q965I4;
DT 02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2012, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Transcription factor zip-4 {ECO:0000305};
GN Name=zip-4 {ECO:0000312|WormBase:Y44E3B.1a};
GN ORFNames=Y44E3B.1 {ECO:0000312|WormBase:Y44E3B.1a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=28662060; DOI=10.1371/journal.pgen.1006876;
RA Tjahjono E., Kirienko N.V.;
RT "A conserved mitochondrial surveillance pathway is required for defense
RT against Pseudomonas aeruginosa.";
RL PLoS Genet. 13:e1006876-e1006876(2017).
CC -!- FUNCTION: Transcription factor that binds to the promoter and the
CC enhancer regions of target genes (By similarity). Involved in
CC responding to mitochondrial damage (PubMed:28662060). Has a protective
CC role in response to infection by the Gram-negative bacterium
CC P.aeruginosa (PubMed:28662060). {ECO:0000250|UniProtKB:P53567,
CC ECO:0000269|PubMed:28662060}.
CC -!- INTERACTION:
CC H2L0N3; Q18909: cebp-1; NbExp=2; IntAct=EBI-6777775, EBI-326791;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=a {ECO:0000312|WormBase:Y44E3B.1a};
CC IsoId=H2L0N3-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:Y44E3B.1b};
CC IsoId=H2L0N3-2; Sequence=VSP_061054;
CC Name=c {ECO:0000312|WormBase:Y44E3B.1c};
CC IsoId=H2L0N3-3; Sequence=VSP_061053;
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown decreases survival upon
CC infection with P.aeruginosa. {ECO:0000269|PubMed:28662060}.
CC -!- SIMILARITY: Belongs to the bZIP family. C/EBP subfamily. {ECO:0000305}.
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DR EMBL; BX284601; CCD73448.1; -; Genomic_DNA.
DR EMBL; BX284601; CCD73449.1; -; Genomic_DNA.
DR EMBL; BX284601; CCD73450.1; -; Genomic_DNA.
DR RefSeq; NP_001040703.1; NM_001047238.5. [H2L0N3-3]
DR RefSeq; NP_491132.1; NM_058731.3.
DR RefSeq; NP_491133.1; NM_058732.3. [H2L0N3-2]
DR AlphaFoldDB; H2L0N3; -.
DR SMR; H2L0N3; -.
DR IntAct; H2L0N3; 1.
DR STRING; 6239.Y44E3B.1a.1; -.
DR EPD; H2L0N3; -.
DR PaxDb; H2L0N3; -.
DR EnsemblMetazoa; Y44E3B.1a.1; Y44E3B.1a.1; WBGene00021552. [H2L0N3-1]
DR EnsemblMetazoa; Y44E3B.1a.2; Y44E3B.1a.2; WBGene00021552. [H2L0N3-1]
DR EnsemblMetazoa; Y44E3B.1b.1; Y44E3B.1b.1; WBGene00021552. [H2L0N3-2]
DR EnsemblMetazoa; Y44E3B.1b.2; Y44E3B.1b.2; WBGene00021552. [H2L0N3-2]
DR EnsemblMetazoa; Y44E3B.1c.1; Y44E3B.1c.1; WBGene00021552. [H2L0N3-3]
DR GeneID; 171900; -.
DR UCSC; Y44E3B.1b.2; c. elegans.
DR CTD; 171900; -.
DR WormBase; Y44E3B.1a; CE18390; WBGene00021552; zip-4.
DR WormBase; Y44E3B.1b; CE28364; WBGene00021552; zip-4.
DR WormBase; Y44E3B.1c; CE39837; WBGene00021552; zip-4.
DR eggNOG; KOG3119; Eukaryota.
DR GeneTree; ENSGT00940000171291; -.
DR HOGENOM; CLU_075902_0_0_1; -.
DR InParanoid; H2L0N3; -.
DR OMA; SHNDCIS; -.
DR OrthoDB; 1436278at2759; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00021552; Expressed in germ line (C elegans) and 4 other tissues.
DR ExpressionAtlas; H2L0N3; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR Pfam; PF07716; bZIP_2; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..318
FT /note="Transcription factor zip-4"
FT /id="PRO_0000452748"
FT DOMAIN 228..291
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..266
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 238..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..274
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 273..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 242..280
FT /evidence="ECO:0000255"
FT COMPBIAS 273..302
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..63
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_061053"
FT VAR_SEQ 296..318
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_061054"
SQ SEQUENCE 318 AA; 36967 MW; 7CB2AD002C42DD18 CRC64;
MYNYNYSRGN KSMGNPPRFH ELTDMPDNGA STSAAAGMFT RQDSLALAAS LQQRDRERNP
VDFMETQLDL DNYLQCFTDL DVPADNVDLN DAELQKANIL YDDDSYEQPQ LNPYERHVAY
GPGFRNPGEY EEQDGYKMNF EVKTEEEKKP ETMKTSKTMT TRRAIKRPSC YDDYQEEGET
SLSDNDESVD DSYYKPKSSK KTAAAVPNFV PKTKARKYNL KPDKEKVEPI YKLKRARNND
AVRKSRNKAK ELQLQKDEEY DEMKKRITQL EAELQSEREG RERDQQLIKQ LIREKESTSK
GPRKSSRNAL ESFNKSNY
