ZIP4_ORYSJ
ID ZIP4_ORYSJ Reviewed; 396 AA.
AC Q6ZJ91; A0A0P0XCW5;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Zinc transporter 4;
DE AltName: Full=ZRT/IRT-like protein 4;
DE Short=OsZIP4;
DE Flags: Precursor;
GN Name=ZIP4; OrderedLocusNames=Os08g0207500, LOC_Os08g10630;
GN ORFNames=OJ1734_E04.11;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND INDUCTION.
RX PubMed=16263903; DOI=10.1093/jxb/eri317;
RA Ishimaru Y., Suzuki M., Kobayashi T., Takahashi M., Nakanishi H., Mori S.,
RA Nishizawa N.K.;
RT "OsZIP4, a novel zinc-regulated zinc transporter in rice.";
RL J. Exp. Bot. 56:3207-3214(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP FUNCTION.
RX PubMed=17630290; DOI=10.1093/jxb/erm147;
RA Ishimaru Y., Masuda H., Suzuki M., Bashir K., Takahashi M., Nakanishi H.,
RA Mori S., Nishizawa N.K.;
RT "Overexpression of the OsZIP4 zinc transporter confers disarrangement of
RT zinc distribution in rice plants.";
RL J. Exp. Bot. 58:2909-2915(2007).
CC -!- FUNCTION: Zinc transporter that mediates zinc uptake from the
CC rhizosphere and may be responsible for the translocation of zinc within
CC the plant. {ECO:0000269|PubMed:16263903, ECO:0000269|PubMed:17630290}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16263903};
CC Multi-pass membrane protein {ECO:0000269|PubMed:16263903}.
CC -!- TISSUE SPECIFICITY: Expressed in phloem cells of roots and shoots.
CC {ECO:0000269|PubMed:16263903}.
CC -!- INDUCTION: By zinc deficiency in roots and shoots.
CC {ECO:0000269|PubMed:16263903}.
CC -!- MISCELLANEOUS: Plants overexpressing ZIP4 show decreased zinc
CC concentration in shoots and seeds, and increased concentration in
CC roots.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000305}.
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DR EMBL; AB126089; BAD18967.1; -; mRNA.
DR EMBL; AP003919; BAD12849.1; -; Genomic_DNA.
DR EMBL; AP008214; BAF23159.1; -; Genomic_DNA.
DR EMBL; AP014964; BAT04317.1; -; Genomic_DNA.
DR EMBL; AK105258; BAG97162.1; -; mRNA.
DR RefSeq; XP_015650399.1; XM_015794913.1.
DR AlphaFoldDB; Q6ZJ91; -.
DR SMR; Q6ZJ91; -.
DR STRING; 4530.OS08T0207500-01; -.
DR PaxDb; Q6ZJ91; -.
DR PRIDE; Q6ZJ91; -.
DR EnsemblPlants; Os08t0207500-01; Os08t0207500-01; Os08g0207500.
DR GeneID; 4344937; -.
DR Gramene; Os08t0207500-01; Os08t0207500-01; Os08g0207500.
DR KEGG; osa:4344937; -.
DR eggNOG; KOG1558; Eukaryota.
DR HOGENOM; CLU_027089_3_0_1; -.
DR InParanoid; Q6ZJ91; -.
DR OMA; TMMIDSV; -.
DR OrthoDB; 981397at2759; -.
DR Proteomes; UP000000763; Chromosome 8.
DR Proteomes; UP000059680; Chromosome 8.
DR Genevisible; Q6ZJ91; OS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006829; P:zinc ion transport; IMP:UniProtKB.
DR InterPro; IPR003689; ZIP.
DR InterPro; IPR004698; Zn/Fe_permease_fun/pln.
DR Pfam; PF02535; Zip; 1.
DR TIGRFAMs; TIGR00820; zip; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Ion transport; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..396
FT /note="Zinc transporter 4"
FT /id="PRO_0000398328"
FT TOPO_DOM 31..59
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..91
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..130
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..245
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 267..273
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..303
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 325..335
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 336..356
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 357..375
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 203..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 396 AA; 39965 MW; 35E643E6386D0A53 CRC64;
MDAMRQSTPR AMLLLCAVLM LAVAPPGAAT AAAVAGCECG NAAAAAVAGE DARGALRLKL
VAIASILAAG AAGVLVPVLG RSFAALRPDG DVFFAVKAFA AGVILATGMV HILPAAFDAL
ASPCGGGRGG GGGFPFAGLV AMAAAMATMM IDSVAAGYYR RSHFKKPRPV DDPADAARAA
GVEEGGAEHA GHVHVHTHAT HGHAHGHVHS HGHGHGHSHG SAPAAATSPE DASVAETIRH
RVVSQVLELG ILVHSVIIGV SLGASLRPSS IRPLVGALSF HQFFEGIGLG GCIVQANFKA
KATVIMATFF SLTAPVGIAL GIAISSSYSK HSSTALVVEG VFNSAAAGIL IYMSLVDLLA
ADFNNPKLQT NTKLQLAVYL ALFLGAGMMS LLAIWA
