CC190_HUMAN
ID CC190_HUMAN Reviewed; 302 AA.
AC Q86UF4; Q5JSG1; Q6ZW57;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Coiled-coil domain-containing protein 190;
GN Name=CCDC190; Synonyms=C1orf110;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q86UF4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86UF4-2; Sequence=VSP_022772, VSP_022773, VSP_022774;
CC -!- CAUTION: It is uncertain whether Met-1 or Met-5 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BC040018; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK123573; BAC85648.1; -; mRNA.
DR EMBL; AL392003; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC040018; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS44269.1; -. [Q86UF4-1]
DR RefSeq; NP_848645.3; NM_178550.4. [Q86UF4-1]
DR AlphaFoldDB; Q86UF4; -.
DR SMR; Q86UF4; -.
DR BioGRID; 130898; 4.
DR IntAct; Q86UF4; 3.
DR STRING; 9606.ENSP00000356886; -.
DR GlyGen; Q86UF4; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q86UF4; -.
DR PhosphoSitePlus; Q86UF4; -.
DR BioMuta; CCDC190; -.
DR PaxDb; Q86UF4; -.
DR PeptideAtlas; Q86UF4; -.
DR PRIDE; Q86UF4; -.
DR ProteomicsDB; 69816; -. [Q86UF4-1]
DR ProteomicsDB; 69817; -. [Q86UF4-2]
DR Antibodypedia; 34325; 93 antibodies from 15 providers.
DR DNASU; 339512; -.
DR Ensembl; ENST00000367910.5; ENSP00000356886.1; ENSG00000185860.14. [Q86UF4-1]
DR Ensembl; ENST00000367911.3; ENSP00000356887.3; ENSG00000185860.14. [Q86UF4-1]
DR GeneID; 339512; -.
DR KEGG; hsa:339512; -.
DR UCSC; uc001gck.3; human. [Q86UF4-1]
DR CTD; 339512; -.
DR GeneCards; CCDC190; -.
DR HGNC; HGNC:28736; CCDC190.
DR HPA; ENSG00000185860; Tissue enhanced (brain, esophagus).
DR neXtProt; NX_Q86UF4; -.
DR OpenTargets; ENSG00000185860; -.
DR PharmGKB; PA142672494; -.
DR VEuPathDB; HostDB:ENSG00000185860; -.
DR eggNOG; ENOG502SAE4; Eukaryota.
DR GeneTree; ENSGT00390000014067; -.
DR HOGENOM; CLU_082019_0_0_1; -.
DR InParanoid; Q86UF4; -.
DR OMA; KVRNAHY; -.
DR OrthoDB; 1433004at2759; -.
DR PhylomeDB; Q86UF4; -.
DR TreeFam; TF338067; -.
DR PathwayCommons; Q86UF4; -.
DR SignaLink; Q86UF4; -.
DR BioGRID-ORCS; 339512; 7 hits in 1030 CRISPR screens.
DR GenomeRNAi; 339512; -.
DR Pharos; Q86UF4; Tdark.
DR PRO; PR:Q86UF4; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q86UF4; protein.
DR Bgee; ENSG00000185860; Expressed in bronchial epithelial cell and 98 other tissues.
DR Genevisible; Q86UF4; HS.
DR InterPro; IPR031525; CC190.
DR PANTHER; PTHR36871; PTHR36871; 1.
DR Pfam; PF15768; CC190; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..302
FT /note="Coiled-coil domain-containing protein 190"
FT /id="PRO_0000274498"
FT REGION 110..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 14..72
FT /evidence="ECO:0000255"
FT COMPBIAS 137..162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 63
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_022772"
FT VAR_SEQ 200..210
FT /note="DSGMACADETR -> GLQWGDNTL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_022773"
FT VAR_SEQ 211..302
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_022774"
FT CONFLICT 200..201
FT /note="DS -> EV (in Ref. 3; BC040018)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 302 AA; 34103 MW; 91D2FD0AC9559D16 CRC64;
MERHMVRGQL YKHFDLERKN AKQAEARLDQ RLQRLKVICL YHVKLLTWEQ RQLQKELQRL
QQAETMKKKF SSYLGNGFQK RPEDVLVFSP QGRQKHRAPQ AKKMRALATR MAQDTCKSKS
QVPPSHDAGL KDPMKSKKQP LSQNNRTACF IKEQPQAQEK DSVNPSKDVD PSKGISVPCQ
NQEVSTNTIE QGPSSSPASD SGMACADETR SKDVALKPDG NTGKQIPPKH MECAGSFEGE
FTKPTFLELL SKARNAHYLR HRVPPESERL LSIGEIFGHG ESSSSRAGKE CENRVPSKFL
PL
