CC197_HUMAN
ID CC197_HUMAN Reviewed; 143 AA.
AC Q8NCU1; A0A1B0GVF2; Q8N7S1;
DT 23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 2.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Uncharacterized protein CCDC197 {ECO:0000305};
DE AltName: Full=Coiled-coil domain-containing protein 197 {ECO:0000312|HGNC:HGNC:19860};
GN Name=CCDC197 {ECO:0000312|HGNC:HGNC:19860};
GN Synonyms=C14orf48 {ECO:0000312|HGNC:HGNC:19860},
GN LINC00521 {ECO:0000312|HGNC:HGNC:19860};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8NCU1; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-750686, EBI-745073;
CC Q8NCU1; Q8TAB5: C1orf216; NbExp=8; IntAct=EBI-750686, EBI-747505;
CC Q8NCU1; Q8IYE0: CCDC146; NbExp=5; IntAct=EBI-750686, EBI-10749669;
CC Q8NCU1; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-750686, EBI-10175300;
CC Q8NCU1; Q9UIA0: CYTH4; NbExp=3; IntAct=EBI-750686, EBI-11521003;
CC Q8NCU1; Q9NRI5-2: DISC1; NbExp=3; IntAct=EBI-750686, EBI-11988027;
CC Q8NCU1; P12035: KRT3; NbExp=3; IntAct=EBI-750686, EBI-2430095;
CC Q8NCU1; O95678: KRT75; NbExp=3; IntAct=EBI-750686, EBI-2949715;
CC Q8NCU1; O95447: LCA5L; NbExp=3; IntAct=EBI-750686, EBI-8473670;
CC Q8NCU1; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-750686, EBI-741158;
CC Q8NCU1; Q9UBU9: NXF1; NbExp=3; IntAct=EBI-750686, EBI-398874;
CC Q8NCU1; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-750686, EBI-11984663;
CC Q8NCU1; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-750686, EBI-358489;
CC Q8NCU1; Q99757: TXN2; NbExp=3; IntAct=EBI-750686, EBI-2932492;
CC Q8NCU1; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-750686, EBI-739895;
CC Q8NCU1; Q9Y3C0: WASHC3; NbExp=7; IntAct=EBI-750686, EBI-712969;
CC Q8NCU1; Q6ZN96; NbExp=3; IntAct=EBI-750686, EBI-10255097;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NCU1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NCU1-2; Sequence=VSP_007204, VSP_007205;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05156.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK097741; BAC05156.1; ALT_INIT; mRNA.
DR EMBL; AL079302; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC021728; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; Q8NCU1; -.
DR SMR; Q8NCU1; -.
DR IntAct; Q8NCU1; 18.
DR BioMuta; CCDC197; -.
DR DMDM; 30172877; -.
DR MassIVE; Q8NCU1; -.
DR PeptideAtlas; Q8NCU1; -.
DR PRIDE; Q8NCU1; -.
DR Ensembl; ENST00000359253.2; ENSP00000490490.1; ENSG00000175699.15. [Q8NCU1-1]
DR GeneCards; CCDC197; -.
DR HGNC; HGNC:19860; CCDC197.
DR neXtProt; NX_Q8NCU1; -.
DR OpenTargets; ENSG00000175699; -.
DR VEuPathDB; HostDB:ENSG00000175699; -.
DR GeneTree; ENSGT00510000049662; -.
DR InParanoid; Q8NCU1; -.
DR PhylomeDB; Q8NCU1; -.
DR PathwayCommons; Q8NCU1; -.
DR SignaLink; Q8NCU1; -.
DR ChiTaRS; LINC00521; human.
DR Pharos; Q8NCU1; Tdark.
DR PRO; PR:Q8NCU1; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8NCU1; protein.
DR Bgee; ENSG00000175699; Expressed in right testis and 49 other tissues.
DR ExpressionAtlas; Q8NCU1; baseline and differential.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..143
FT /note="Uncharacterized protein CCDC197"
FT /id="PRO_0000089892"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 121..127
FT /note="IASRSGC -> MLLSHNK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_007204"
FT VAR_SEQ 128..143
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_007205"
SQ SEQUENCE 143 AA; 16081 MW; 81EB1EF2211C7E6B CRC64;
MAAMDTGQRA DPSNPGDKEG DLQGLWQELY QLQAKQKKLK REVEKHKLFE DYLIKVLEKI
PEGCTGWEEP EEVLVEATVK HYGKLFTASQ DTQKRLEAFC QMIQAVHRSL ESLEEDHRAL
IASRSGCVSC RRSATASRSS GGS
