CC198_HUMAN
ID CC198_HUMAN Reviewed; 296 AA.
AC Q9NVL8; Q17R99; Q53G04;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Uncharacterized protein CCDC198 {ECO:0000305};
GN Name=CCDC198 {ECO:0000312|HGNC:HGNC:20189}; Synonyms=C14orf105;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT CYS-235.
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT CYS-235.
RC TISSUE=Kidney;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT CYS-235.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT CYS-235.
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9NVL8; Q8NA61: CBY2; NbExp=3; IntAct=EBI-10238351, EBI-741724;
CC Q9NVL8; Q8IZU0: FAM9B; NbExp=3; IntAct=EBI-10238351, EBI-10175124;
CC Q9NVL8; Q13643: FHL3; NbExp=3; IntAct=EBI-10238351, EBI-741101;
CC Q9NVL8; Q08379: GOLGA2; NbExp=3; IntAct=EBI-10238351, EBI-618309;
CC Q9NVL8; Q6A162: KRT40; NbExp=3; IntAct=EBI-10238351, EBI-10171697;
CC Q9NVL8; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-10238351, EBI-741037;
CC Q9NVL8; Q99750: MDFI; NbExp=3; IntAct=EBI-10238351, EBI-724076;
CC Q9NVL8; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-10238351, EBI-742948;
CC Q9NVL8; Q5VU43: PDE4DIP; NbExp=3; IntAct=EBI-10238351, EBI-1105124;
CC Q9NVL8; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-10238351, EBI-302345;
CC Q9NVL8; Q8IUQ4: SIAH1; NbExp=3; IntAct=EBI-10238351, EBI-747107;
CC Q9NVL8; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-10238351, EBI-2212028;
CC Q9NVL8; Q8IYF3: TEX11; NbExp=3; IntAct=EBI-10238351, EBI-742397;
CC Q9NVL8; Q13077: TRAF1; NbExp=3; IntAct=EBI-10238351, EBI-359224;
CC Q9NVL8; Q12933: TRAF2; NbExp=3; IntAct=EBI-10238351, EBI-355744;
CC Q9NVL8; P14373: TRIM27; NbExp=3; IntAct=EBI-10238351, EBI-719493;
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DR EMBL; AK001512; BAA91732.1; -; mRNA.
DR EMBL; AK223127; BAD96847.1; -; mRNA.
DR EMBL; AL161804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL355834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471061; EAW80707.1; -; Genomic_DNA.
DR EMBL; BC117405; AAI17406.1; -; mRNA.
DR EMBL; BC143566; AAI43567.1; -; mRNA.
DR CCDS; CCDS9730.1; -.
DR RefSeq; NP_001269985.1; NM_001283056.1.
DR RefSeq; NP_001269986.1; NM_001283057.1.
DR RefSeq; NP_001269987.1; NM_001283058.1.
DR RefSeq; NP_001269988.1; NM_001283059.1.
DR RefSeq; NP_060638.2; NM_018168.3.
DR AlphaFoldDB; Q9NVL8; -.
DR BioGRID; 120492; 32.
DR IntAct; Q9NVL8; 19.
DR MINT; Q9NVL8; -.
DR iPTMnet; Q9NVL8; -.
DR PhosphoSitePlus; Q9NVL8; -.
DR BioMuta; CCDC198; -.
DR DMDM; 160332322; -.
DR MassIVE; Q9NVL8; -.
DR PaxDb; Q9NVL8; -.
DR PeptideAtlas; Q9NVL8; -.
DR PRIDE; Q9NVL8; -.
DR ProteomicsDB; 82824; -.
DR Antibodypedia; 24135; 27 antibodies from 11 providers.
DR DNASU; 55195; -.
DR Ensembl; ENST00000216445.8; ENSP00000216445.3; ENSG00000100557.10.
DR GeneID; 55195; -.
DR KEGG; hsa:55195; -.
DR MANE-Select; ENST00000216445.8; ENSP00000216445.3; NM_018168.4; NP_060638.2.
DR UCSC; uc001xcy.4; human.
DR CTD; 55195; -.
DR GeneCards; CCDC198; -.
DR HGNC; HGNC:20189; CCDC198.
DR HPA; ENSG00000100557; Tissue enhanced (fallopian tube, kidney, liver, pancreas).
DR neXtProt; NX_Q9NVL8; -.
DR OpenTargets; ENSG00000100557; -.
DR PharmGKB; PA134868494; -.
DR VEuPathDB; HostDB:ENSG00000100557; -.
DR GeneTree; ENSGT00390000001071; -.
DR HOGENOM; CLU_081875_0_0_1; -.
DR InParanoid; Q9NVL8; -.
DR OMA; GPRAMYF; -.
DR OrthoDB; 1196221at2759; -.
DR PhylomeDB; Q9NVL8; -.
DR TreeFam; TF336148; -.
DR PathwayCommons; Q9NVL8; -.
DR SignaLink; Q9NVL8; -.
DR BioGRID-ORCS; 55195; 9 hits in 1036 CRISPR screens.
DR GenomeRNAi; 55195; -.
DR Pharos; Q9NVL8; Tdark.
DR PRO; PR:Q9NVL8; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q9NVL8; protein.
DR Bgee; ENSG00000100557; Expressed in right uterine tube and 105 other tissues.
DR ExpressionAtlas; Q9NVL8; baseline and differential.
DR Genevisible; Q9NVL8; HS.
DR InterPro; IPR029235; DUF4619.
DR PANTHER; PTHR16065; PTHR16065; 1.
DR Pfam; PF15398; DUF4619; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..296
FT /note="Uncharacterized protein CCDC198"
FT /id="PRO_0000089913"
FT REGION 173..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 235
FT /note="Y -> C (in dbSNP:rs1152530)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2,
FT ECO:0000269|Ref.4"
FT /id="VAR_024310"
FT CONFLICT 132
FT /note="Missing (in Ref. 5; AAI17406/AAI43567 and 4;
FT EAW80707)"
FT /evidence="ECO:0000305"
FT CONFLICT 223
FT /note="N -> D (in Ref. 1; BAA91732)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 296 AA; 34690 MW; 6718547F055B1C49 CRC64;
MGLSHSKTHL RVIKVAPLQN KEVETPSAGR VDFAFNQNLE EKTSYSLARL QDQNKALEGQ
LPPLQENWYG RYSTASRDMY FDIPLEHRET SIIKRHPPQR LQKLEPIDLP RVITSGRLLS
QREARTMHKA KQVLEKKMQT PMYTSENRQY LHKMQVLEMI RKRQEAQMEL KKSLHGEARI
NKQSPRDHKA KKTLQSTPRN DDHDLLTMLP DEILNRGPGN SKNTEFLKHQ AVNNYCPWKI
GKMETWLHEQ EAQGQLLWDS SSSDSDEQGK DEKKPRALVR TRTERIPLFD EFFDQE
