CC1L1_MOUSE
ID CC1L1_MOUSE Reviewed; 356 AA.
AC P51676; A0JP35;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=C-C chemokine receptor 1-like protein 1;
DE AltName: Full=Macrophage inflammatory protein 1 alpha receptor-like 1;
GN Name=Ccr1l1; Synonyms=Cmkbr1l1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RX PubMed=7542241; DOI=10.1074/jbc.270.29.17494;
RA Gao J.-L., Murphy P.M.;
RT "Cloning and differential tissue-specific expression of three mouse beta
RT chemokine receptor-like genes, including the gene for a functional
RT macrophage inflammatory protein-1 alpha receptor.";
RL J. Biol. Chem. 270:17494-17501(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable receptor for a C-C type chemokine.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Detected in the spleen, liver and leukocytes.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U28405; AAA89154.1; -; Genomic_DNA.
DR EMBL; CH466671; EDL37174.1; -; Genomic_DNA.
DR EMBL; BC127143; AAI27144.1; -; mRNA.
DR EMBL; BC128466; AAI28467.1; -; mRNA.
DR CCDS; CCDS23667.1; -.
DR PIR; I49340; I49340.
DR RefSeq; NP_031744.3; NM_007718.3.
DR AlphaFoldDB; P51676; -.
DR SMR; P51676; -.
DR STRING; 10090.ENSMUSP00000071353; -.
DR PaxDb; P51676; -.
DR PRIDE; P51676; -.
DR DNASU; 12770; -.
DR Ensembl; ENSMUST00000071404; ENSMUSP00000071353; ENSMUSG00000064039.
DR GeneID; 12770; -.
DR KEGG; mmu:12770; -.
DR UCSC; uc009sgz.2; mouse.
DR CTD; 12770; -.
DR MGI; MGI:104617; Ccr1l1.
DR VEuPathDB; HostDB:ENSMUSG00000064039; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01020000230359; -.
DR HOGENOM; CLU_009579_8_3_1; -.
DR InParanoid; P51676; -.
DR OMA; FVSAFED; -.
DR OrthoDB; 900867at2759; -.
DR PhylomeDB; P51676; -.
DR TreeFam; TF330966; -.
DR BioGRID-ORCS; 12770; 0 hits in 73 CRISPR screens.
DR PRO; PR:P51676; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; P51676; protein.
DR Bgee; ENSMUSG00000064039; Expressed in placenta labyrinth and 8 other tissues.
DR Genevisible; P51676; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0009897; C:external side of plasma membrane; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0019957; F:C-C chemokine binding; ISO:MGI.
DR GO; GO:0016493; F:C-C chemokine receptor activity; ISO:MGI.
DR GO; GO:0071791; F:chemokine (C-C motif) ligand 5 binding; ISO:MGI.
DR GO; GO:0035717; F:chemokine (C-C motif) ligand 7 binding; ISO:MGI.
DR GO; GO:0004950; F:chemokine receptor activity; ISO:MGI.
DR GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; ISO:MGI.
DR GO; GO:0006816; P:calcium ion transport; ISO:MGI.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0007267; P:cell-cell signaling; ISO:MGI.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; ISO:MGI.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; ISO:MGI.
DR GO; GO:0006887; P:exocytosis; ISO:MGI.
DR GO; GO:0006955; P:immune response; ISO:MGI.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0030502; P:negative regulation of bone mineralization; ISO:MGI.
DR GO; GO:0010629; P:negative regulation of gene expression; ISO:MGI.
DR GO; GO:0051928; P:positive regulation of calcium ion transport; ISO:MGI.
DR GO; GO:0030335; P:positive regulation of cell migration; ISO:MGI.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:MGI.
DR GO; GO:0090026; P:positive regulation of monocyte chemotaxis; ISO:MGI.
DR GO; GO:0045672; P:positive regulation of osteoclast differentiation; ISO:MGI.
DR InterPro; IPR002236; Chemokine_CCR1.
DR InterPro; IPR000355; Chemokine_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00657; CCCHEMOKINER.
DR PRINTS; PR01106; CHEMOKINER1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..356
FT /note="C-C chemokine receptor 1-like protein 1"
FT /id="PRO_0000069298"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..60
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..67
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..92
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 93..108
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..130
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..172
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..224
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..265
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..282
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..306
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 307..356
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 107..184
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 38
FT /note="L -> P (in Ref. 1; AAA89154)"
FT /evidence="ECO:0000305"
FT CONFLICT 334
FT /note="V -> E (in Ref. 1; AAA89154)"
FT /evidence="ECO:0000305"
FT CONFLICT 343..344
FT /note="TP -> RL (in Ref. 1; AAA89154)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 356 AA; 40849 MW; CA84549CFA1DEA9B CRC64;
MEIPAVTEPS YNTVAKNDFM SGFLCFSINV RAFGITVLTP LYSLVFIIGV IGHVLVVLVL
IQHKRLRNMT SIYLFNLAIS DLVFLSTLPF WVDYIMKGDW IFGNAMCKFV SGFYYLGLYS
DMFFITLLTI DRYLAVVHVV FALRARTVTF GIISSIITWV LAALVSIPCL YVFKSQMEFT
YHTCRAILPR KSLIRFLRFQ ALTMNILGLI LPLLAMIICY TRIINVLHRR PNKKKAKVMR
LIFVITLLFF LLLAPYYLAA FVSAFEDVLF TPSCLRSQQV DLSLMITEAL AYTHCCVNPV
IYVFVGKRFR KYLWQLFRRH TAITLPQWLP FLSVDRAQRA SATPPSTVEI ETSADL
