ZITB_ECO57
ID ZITB_ECO57 Reviewed; 311 AA.
AC Q8X400; Q8X3F7;
DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Zinc transporter ZitB;
GN Name=zitB; OrderedLocusNames=Z0922, ECs0780;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Involved in zinc efflux across the cytoplasmic membrane, thus
CC reducing zinc accumulation in the cytoplasm and rendering bacteria more
CC resistant to zinc. It may contribute to zinc homeostasis at low
CC concentrations of zinc (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR EMBL; AE005174; AAG55081.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB34203.1; -; Genomic_DNA.
DR PIR; D90726; D90726.
DR PIR; E85577; E85577.
DR RefSeq; NP_308807.1; NC_002695.1.
DR RefSeq; WP_000951313.1; NZ_LPWC02000002.1.
DR AlphaFoldDB; Q8X400; -.
DR SMR; Q8X400; -.
DR STRING; 155864.EDL933_0825; -.
DR EnsemblBacteria; AAG55081; AAG55081; Z0922.
DR EnsemblBacteria; BAB34203; BAB34203; ECs_0780.
DR GeneID; 917515; -.
DR KEGG; ece:Z0922; -.
DR KEGG; ecs:ECs_0780; -.
DR PATRIC; fig|386585.9.peg.899; -.
DR eggNOG; COG1230; Bacteria.
DR HOGENOM; CLU_013430_0_0_6; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1510.10; -; 1.
DR Gene3D; 3.30.70.1350; -; 1.
DR HAMAP; MF_00552; ZitB; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR036837; Cation_efflux_CTD_sf.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR InterPro; IPR023500; Zn_transptr_ZitB.
DR Pfam; PF01545; Cation_efflux; 1.
DR SUPFAM; SSF160240; SSF160240; 1.
DR SUPFAM; SSF161111; SSF161111; 1.
DR TIGRFAMs; TIGR01297; CDF; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport; Zinc;
KW Zinc transport.
FT CHAIN 1..311
FT /note="Zinc transporter ZitB"
FT /id="PRO_0000206108"
FT TOPO_DOM 1..18
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 40..45
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..87
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..119
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..157
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 201..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 1..2
FT /note="MA -> MAHS (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 311 AA; 34468 MW; 2D0F139E0C537587 CRC64;
MAHSHTSSHL PEDNNARRLL YAFGVTAGFM LVEVIGGFLS GSLALLADAG HMLTDTAALL
FALLAVQFSR RPPTIRHTFG WLRLTTLAAF VNAIALVVIT ILIVWEAIER FRTPRPVEGG
MMMAIAVAGL LANILSFWLL HHGSEEKNLN VRAAALHVLG DLLGSVGAII AALIIIWTGW
TPADPILSIL VSLLVLRSAW RLLKDSVNEL LEGAPVSLDI AELKRRMCRE IPEVRNVHHV
HVWMVGEKPV MTLHVQVIPP HDHDALLDQI QHYLMDHYQI EHATIQMEYQ PCHGPDCHLN
EGVSGHSHHH H
