ID   ZITB_PECAS              Reviewed;         320 AA.
AC   Q6D7E5;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Zinc transporter ZitB {ECO:0000255|HAMAP-Rule:MF_00552};
GN   Name=zitB {ECO:0000255|HAMAP-Rule:MF_00552}; OrderedLocusNames=ECA1380;
OS   Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia
OS   carotovora subsp. atroseptica).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Pectobacterium.
OX   NCBI_TaxID=218491;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SCRI 1043 / ATCC BAA-672;
RX   PubMed=15263089; DOI=10.1073/pnas.0402424101;
RA   Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J.,
RA   Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K.,
RA   Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J.,
RA   Fraser A., Hance Z., Hauser H., Jagels K., Moule S., Norbertczak H.,
RA   Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S.,
RA   Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K.;
RT   "Genome sequence of the enterobacterial phytopathogen Erwinia carotovora
RT   subsp. atroseptica and characterization of virulence factors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004).
CC   -!- FUNCTION: Involved in zinc efflux across the cytoplasmic membrane, thus
CC       reducing zinc accumulation in the cytoplasm and rendering bacteria more
CC       resistant to zinc. It may contribute to zinc homeostasis at low
CC       concentrations of zinc. {ECO:0000255|HAMAP-Rule:MF_00552}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00552}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00552}.
CC   -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC       transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00552}.
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DR   EMBL; BX950851; CAG74290.1; -; Genomic_DNA.
DR   RefSeq; WP_011092965.1; NC_004547.2.
DR   AlphaFoldDB; Q6D7E5; -.
DR   SMR; Q6D7E5; -.
DR   STRING; 218491.ECA1380; -.
DR   EnsemblBacteria; CAG74290; CAG74290; ECA1380.
DR   KEGG; eca:ECA1380; -.
DR   PATRIC; fig|218491.5.peg.1414; -.
DR   eggNOG; COG1230; Bacteria.
DR   HOGENOM; CLU_013430_0_0_6; -.
DR   OMA; GHEKMLH; -.
DR   OrthoDB; 948593at2; -.
DR   Proteomes; UP000007966; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   HAMAP; MF_00552; ZitB; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR036837; Cation_efflux_CTD_sf.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   InterPro; IPR023500; Zn_transptr_ZitB.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   SUPFAM; SSF160240; SSF160240; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
DR   TIGRFAMs; TIGR01297; CDF; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport; Zinc;
KW   Zinc transport.
FT   CHAIN           1..320
FT                   /note="Zinc transporter ZitB"
FT                   /id="PRO_0000206109"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
SQ   SEQUENCE   320 AA;  35538 MW;  3092380874929AE5 CRC64;
     MAHNHSHTES GNSKRLLAAF IITATFMVAE VIGGLLSGSL ALLADAGHML TDAAALFVAL
     VAVRFAQRKP NARHTFGYLR LTTLAAFVNA LTLILITAFI FWEAIQRFYD PQPVAGVPML
     LVAIAGLLAN IVAFWLLHHG SEEKNINVRA AALHVLGDLL GSVGAIAAAI IILYTNWTPI
     DPILSILVSC LVLRSAWALL KESIHELLEG TPSQLSVEAL QKDVTLNIPE VRNIHHVHLW
     QVGEKPMMTL HAQVVPPHDH DALLRRIQEY LLKHYQIEHA TIQMEYQRCD DDHCSFHQEN
     HHLAIHDGEK HDAEGHHHKH