ID   ZITB_SALTI              Reviewed;         312 AA.
AC   Q8Z8B6;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Zinc transporter ZitB {ECO:0000255|HAMAP-Rule:MF_00552};
GN   Name=zitB {ECO:0000255|HAMAP-Rule:MF_00552};
GN   OrderedLocusNames=STY0799, t2120;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Involved in zinc efflux across the cytoplasmic membrane, thus
CC       reducing zinc accumulation in the cytoplasm and rendering bacteria more
CC       resistant to zinc. It may contribute to zinc homeostasis at low
CC       concentrations of zinc. {ECO:0000255|HAMAP-Rule:MF_00552}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00552}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00552}.
CC   -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC       transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00552}.
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DR   EMBL; AL513382; CAD05215.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO69737.1; -; Genomic_DNA.
DR   RefSeq; NP_455309.1; NC_003198.1.
DR   RefSeq; WP_000951257.1; NZ_WSUR01000021.1.
DR   AlphaFoldDB; Q8Z8B6; -.
DR   SMR; Q8Z8B6; -.
DR   STRING; 220341.16501985; -.
DR   EnsemblBacteria; AAO69737; AAO69737; t2120.
DR   KEGG; stt:t2120; -.
DR   KEGG; sty:STY0799; -.
DR   PATRIC; fig|220341.7.peg.804; -.
DR   eggNOG; COG1230; Bacteria.
DR   HOGENOM; CLU_013430_0_0_6; -.
DR   OMA; GHEKMLH; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   HAMAP; MF_00552; ZitB; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR036837; Cation_efflux_CTD_sf.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   InterPro; IPR023500; Zn_transptr_ZitB.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   SUPFAM; SSF160240; SSF160240; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
DR   TIGRFAMs; TIGR01297; CDF; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Transmembrane;
KW   Transmembrane helix; Transport; Zinc; Zinc transport.
FT   CHAIN           1..312
FT                   /note="Zinc transporter ZitB"
FT                   /id="PRO_0000206110"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
SQ   SEQUENCE   312 AA;  34531 MW;  EA29EF94B3A18736 CRC64;
     MAHSHSHADS HLPKDNNARR LLFAFIVTAG FMLLEVVGGI LSGSLALLAD AGHMLTDAAA
     LLFALLVVQF SRRPPTVRHT FGWLRLTTLA AFVNAIALVV ITLLIVWEAI ERFYTPRPVA
     GNLMMVIAVA GLLANLFAFW ILHRGSDEKN LNVRAAALHV MGDLLGSVGA IVAALIIIWT
     GWTPADPILS ILVSVLVLRS AWRLLKDSVN ELLEGAPVSL DINALQRHLS REIPEVRNVH
     HVHVWMVGEK PVMTLHAQVI PPHDHDALLE RIQDFLMHEY HIAHATIQME YQMCHGPDCH
     LNQTPSGHVH HH