ID   ZITB_SALTY              Reviewed;         312 AA.
AC   Q8ZQT3;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Zinc transporter ZitB {ECO:0000255|HAMAP-Rule:MF_00552};
GN   Name=zitB {ECO:0000255|HAMAP-Rule:MF_00552}; OrderedLocusNames=STM0758;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Involved in zinc efflux across the cytoplasmic membrane, thus
CC       reducing zinc accumulation in the cytoplasm and rendering bacteria more
CC       resistant to zinc. It may contribute to zinc homeostasis at low
CC       concentrations of zinc. {ECO:0000255|HAMAP-Rule:MF_00552}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00552}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00552}.
CC   -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC       transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00552}.
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DR   EMBL; AE006468; AAL19697.1; -; Genomic_DNA.
DR   RefSeq; NP_459738.1; NC_003197.2.
DR   RefSeq; WP_000951251.1; NC_003197.2.
DR   AlphaFoldDB; Q8ZQT3; -.
DR   SMR; Q8ZQT3; -.
DR   STRING; 99287.STM0758; -.
DR   PaxDb; Q8ZQT3; -.
DR   EnsemblBacteria; AAL19697; AAL19697; STM0758.
DR   GeneID; 1252278; -.
DR   KEGG; stm:STM0758; -.
DR   PATRIC; fig|99287.12.peg.789; -.
DR   HOGENOM; CLU_013430_0_0_6; -.
DR   OMA; GHEKMLH; -.
DR   PhylomeDB; Q8ZQT3; -.
DR   BioCyc; SENT99287:STM0758-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   HAMAP; MF_00552; ZitB; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR036837; Cation_efflux_CTD_sf.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   InterPro; IPR023500; Zn_transptr_ZitB.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   SUPFAM; SSF160240; SSF160240; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
DR   TIGRFAMs; TIGR01297; CDF; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport; Zinc;
KW   Zinc transport.
FT   CHAIN           1..312
FT                   /note="Zinc transporter ZitB"
FT                   /id="PRO_0000206111"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
SQ   SEQUENCE   312 AA;  34461 MW;  2521FF85B2B7B3A6 CRC64;
     MAHSHSHADS HLPKDNNARR LLFAFIVTAG FMLLEVVGGI LSGSLALLAD AGHMLTDAAA
     LLFALLAVQF SRRPPTVRHT FGWLRLTTLA AFVNAIALVV ITLLIVWEAI ERFYTPRPVA
     GNLMMVIAVA GLLANLFAFW ILHRGSDEKN LNVRAAALHV MGDLLGSVGA IVAALIIIWT
     GWTPADPILS ILVSVLVLRS AWRLLKDSVN ELLEGAPVSL DINALQRHLS REIPEVRNVH
     HVHVWMVGEK PVMTLHAQVI PPHDHDALLE RIQDFLMHEY HIAHATIQME YQVCHGPDCH
     LNQTSSGHVH HH