ID   ZITB_YERPS              Reviewed;         312 AA.
AC   Q66D85;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Zinc transporter ZitB {ECO:0000255|HAMAP-Rule:MF_00552};
GN   Name=zitB {ECO:0000255|HAMAP-Rule:MF_00552}; OrderedLocusNames=YPTB1164;
OS   Yersinia pseudotuberculosis serotype I (strain IP32953).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=273123;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP32953;
RX   PubMed=15358858; DOI=10.1073/pnas.0404012101;
RA   Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O.,
RA   Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L.,
RA   Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C.,
RA   Simonet M., Chenal-Francisque V., Souza B., Dacheux D., Elliott J.M.,
RA   Derbise A., Hauser L.J., Garcia E.;
RT   "Insights into the evolution of Yersinia pestis through whole-genome
RT   comparison with Yersinia pseudotuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004).
CC   -!- FUNCTION: Involved in zinc efflux across the cytoplasmic membrane, thus
CC       reducing zinc accumulation in the cytoplasm and rendering bacteria more
CC       resistant to zinc. It may contribute to zinc homeostasis at low
CC       concentrations of zinc. {ECO:0000255|HAMAP-Rule:MF_00552}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00552}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00552}.
CC   -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC       transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00552}.
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DR   EMBL; BX936398; CAH20404.1; -; Genomic_DNA.
DR   RefSeq; WP_011191947.1; NZ_CP009712.1.
DR   AlphaFoldDB; Q66D85; -.
DR   SMR; Q66D85; -.
DR   EnsemblBacteria; CAH20404; CAH20404; YPTB1164.
DR   GeneID; 66842402; -.
DR   KEGG; ypo:BZ17_1366; -.
DR   KEGG; yps:YPTB1164; -.
DR   PATRIC; fig|273123.14.peg.1458; -.
DR   OMA; GHEKMLH; -.
DR   Proteomes; UP000001011; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   HAMAP; MF_00552; ZitB; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR036837; Cation_efflux_CTD_sf.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   InterPro; IPR023500; Zn_transptr_ZitB.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   SUPFAM; SSF160240; SSF160240; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
DR   TIGRFAMs; TIGR01297; CDF; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Transmembrane;
KW   Transmembrane helix; Transport; Zinc; Zinc transport.
FT   CHAIN           1..312
FT                   /note="Zinc transporter ZitB"
FT                   /id="PRO_0000206114"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
SQ   SEQUENCE   312 AA;  34855 MW;  1A57EB537DDFF88B CRC64;
     MAVSAIFSQD SNSKRLLIAF AITTLFMVTE AIGGWLSGSL ALLADTGHML TDSAALFIAL
     MAVHFSQRKP DPRHTFGYLR LTTLAAFVNA AALLLIVILI VWEAVHRFFS PHEVMGTPML
     IIAIAGLLAN IFCFWILHKG EEEKNINVRA AALHVLSDLL GSVGAMIAAI VILTTGWTPI
     DPILSVLVSV LILRNAWRLL KESFHELLEG APQEIDINKL RKDLCTNIYE VRNIHHVHLW
     QVGEQRLMTL HAQVIPPLDH DALLQRIQDY LLHHYRISHA TVQMEYQHCG TPDCGINQAA
     PADGHHRHHH HE