ZMAT1_MOUSE
ID ZMAT1_MOUSE Reviewed; 714 AA.
AC Q3V0C1; A2AFB3; Q5DTV1; Q8BI78;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 2.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Zinc finger matrin-type protein 1;
GN Name=Zmat1; Synonyms=Kiaa1789;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-688 (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 95-714 (ISOFORM 2).
RC TISSUE=Fetal brain;
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT screening of terminal sequences of cDNA clones randomly sampled from size-
RT fractionated libraries.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q3V0C1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3V0C1-2; Sequence=VSP_029535;
CC Name=3;
CC IsoId=Q3V0C1-3; Sequence=VSP_029534, VSP_029535;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC32933.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAM26540.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK046974; BAC32933.1; ALT_FRAME; mRNA.
DR EMBL; AK133258; BAE21583.1; -; mRNA.
DR EMBL; AL672063; CAM26540.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AK220419; BAD90465.1; -; mRNA.
DR AlphaFoldDB; Q3V0C1; -.
DR STRING; 10090.ENSMUSP00000066815; -.
DR iPTMnet; Q3V0C1; -.
DR PhosphoSitePlus; Q3V0C1; -.
DR MaxQB; Q3V0C1; -.
DR PaxDb; Q3V0C1; -.
DR PRIDE; Q3V0C1; -.
DR ProteomicsDB; 302060; -. [Q3V0C1-1]
DR ProteomicsDB; 302061; -. [Q3V0C1-2]
DR ProteomicsDB; 302062; -. [Q3V0C1-3]
DR UCSC; uc009ugw.1; mouse. [Q3V0C1-3]
DR UCSC; uc012hon.1; mouse. [Q3V0C1-1]
DR MGI; MGI:2442284; Zmat1.
DR eggNOG; ENOG502S5D7; Eukaryota.
DR InParanoid; Q3V0C1; -.
DR PhylomeDB; Q3V0C1; -.
DR PRO; PR:Q3V0C1; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q3V0C1; protein.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SMART; SM00451; ZnF_U1; 2.
DR SUPFAM; SSF57667; SSF57667; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..714
FT /note="Zinc finger matrin-type protein 1"
FT /id="PRO_0000311349"
FT ZN_FING 89..119
FT /note="Matrin-type 1"
FT ZN_FING 230..254
FT /note="Matrin-type 2"
FT REGION 172..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..587
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..667
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..702
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..226
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029534"
FT VAR_SEQ 258..272
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072, ECO:0000303|Ref.3"
FT /id="VSP_029535"
FT CONFLICT 145
FT /note="C -> R (in Ref. 2; BAD90465)"
FT /evidence="ECO:0000305"
FT CONFLICT 178
FT /note="H -> R (in Ref. 1; BAE21583)"
FT /evidence="ECO:0000305"
FT CONFLICT 341
FT /note="E -> G (in Ref. 1; BAC32933)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 714 AA; 84176 MW; 1E64EB7E49B62029 CRC64;
MHQQAATSSR CQGWSPRYQG WSPRFQGWSP RFHGWNPRFR GWNPHCRGWS PCFQGWSPRC
QTFPPKINRI SSNYPTCDGQ EQPAYFTDNF CKPCGVVLQH ESERISHFES EIHAQNVKFF
FQMHGEQSEV PGRKVNMHAG NSQVCSSGEV NRNNFTDLHN MSFDSLAAAP SHYVGKSHSP
TQNQSLEEHD QVSPSTCSPK MDEPNTTPAP PPFLKSVIVK PPPAYRMRTY VCHICSITFT
SLHMFRSHMQ GTEHQIKRAQ HLWTHWQCTQ LLESHVINQV KNSKKMQESC QAECGDDIKM
KKSRELEPKG HFREMEDNYM EAQAHEYREM VDSRPRHKML EQTLPLENFW AHPGPYNDSR
ALEEQLPHNL PAESKTYDSF QDELEDYIKG QKARGLDPNT SFRRMSESYR YRDQRYRERV
DSEHRQRPCE ERFSFEAPQT YQQEYSASPV EGQSPHWLPS HSKRRNDDFQ NEFDDYNKVQ
ESRESEPKTS FRRMDSSFET HNYEEMVDRR SSHTMFEEGL PCETFQTYTD PYSSAQAVEN
TLPHCLPAYE NQPSLDAESH YQLTTEEFSE MPASLSLSQQ EDNPSSYNVD YDIYKHLPSN
DNASAHETSH RRRRQKRKRH LEEGKERPEK EQSKHKRKRS YQDKDLDKDK LIKQSKREED
KAGVSSEKTK HRRKKRKHET SSEKEERKHK KEKKKSVEER TEEEILWDES ILGF
