ZMAT3_HUMAN
ID ZMAT3_HUMAN Reviewed; 289 AA.
AC Q9HA38; B3KVA6; D3DNR1; Q96A21;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Zinc finger matrin-type protein 3;
DE AltName: Full=Zinc finger protein WIG-1;
DE AltName: Full=p53-activated gene 608 protein;
GN Name=ZMAT3 {ECO:0000312|EMBL:AAH02896.1};
GN Synonyms=PAG608 {ECO:0000312|EMBL:AAK83287.1},
GN WIG1 {ECO:0000312|EMBL:AAK83287.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAK83287.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=11689294; DOI=10.1016/s0304-3835(01)00699-1;
RA Varmeh-Ziaie S., Ichimura K., Yang F., Rabbits P., Collins V.P.;
RT "Cloning and chromosomal localization of human WIG-1/PAG608 and
RT demonstration of amplification with increased expression in primary
RT squamous cell carcinoma of the lung.";
RL Cancer Lett. 174:179-187(2001).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAK71491.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION, AND
RP INDUCTION.
RC TISSUE=Testis {ECO:0000312|EMBL:AAK71491.1};
RX PubMed=11571644; DOI=10.1038/sj.onc.1204722;
RA Hellborg F., Qian W., Mendez-Vidal C., Asker C., Kost-Alimova M.,
RA Wilhelm M., Imreh S., Wiman K.G.;
RT "Human wig-1, a p53 target gene that encodes a growth inhibitory zinc
RT finger protein.";
RL Oncogene 20:5466-5474(2001).
RN [3] {ECO:0000312|EMBL:BAB14020.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Mammary gland {ECO:0000312|EMBL:BAB14020.1};
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000312|EMBL:AAH02896.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung carcinoma {ECO:0000312|EMBL:AAH02896.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7] {ECO:0000305}
RP SUBUNIT.
RX PubMed=16844115; DOI=10.1016/j.febslet.2006.07.005;
RA Mendez Vidal C., Prahl M., Wiman K.G.;
RT "The p53-induced Wig-1 protein binds double-stranded RNAs with structural
RT characteristics of siRNAs and miRNAs.";
RL FEBS Lett. 580:4401-4408(2006).
CC -!- FUNCTION: Acts as a bona fide target gene of p53/TP53. May play a role
CC in the TP53-dependent growth regulatory pathway. May contribute to
CC TP53-mediated apoptosis by regulation of TP53 expression and
CC translocation to the nucleus and nucleolus.
CC {ECO:0000269|PubMed:11571644}.
CC -!- SUBUNIT: Interacts with dsRNA. {ECO:0000269|PubMed:16844115}.
CC -!- INTERACTION:
CC Q9HA38; Q9UKV8: AGO2; NbExp=5; IntAct=EBI-2548480, EBI-528269;
CC Q9HA38; Q08211: DHX9; NbExp=3; IntAct=EBI-2548480, EBI-352022;
CC Q9HA38; P22626: HNRNPA2B1; NbExp=3; IntAct=EBI-2548480, EBI-299649;
CC Q9HA38; O75569: PRKRA; NbExp=3; IntAct=EBI-2548480, EBI-713955;
CC Q9HA38; Q8IUQ4: SIAH1; NbExp=3; IntAct=EBI-2548480, EBI-747107;
CC Q9HA38; O95793: STAU1; NbExp=3; IntAct=EBI-2548480, EBI-358174;
CC Q9HA38; Q15633: TARBP2; NbExp=3; IntAct=EBI-2548480, EBI-978581;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11571644}. Nucleus,
CC nucleolus {ECO:0000269|PubMed:11571644}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9HA38-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9HA38-2; Sequence=VSP_040093;
CC -!- TISSUE SPECIFICITY: Highly expressed in adult brain, and moderately in
CC adult kidney and testis. Not detected in fetal brain, heart, pancreas,
CC adrenal gland, liver or small intestine. {ECO:0000269|PubMed:11689294}.
CC -!- INDUCTION: By DNA damage in a p53/TP53-dependent manner. Up-regulated
CC following ionizing radiation in primary squamous cell carcinoma of the
CC lung and in various colon cancer cell lines.
CC {ECO:0000269|PubMed:11571644, ECO:0000269|PubMed:11689294}.
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DR EMBL; AF355465; AAK83287.1; -; mRNA.
DR EMBL; AY037945; AAK71491.1; -; mRNA.
DR EMBL; AK022358; BAB14020.1; -; mRNA.
DR EMBL; AK122768; BAG53718.1; -; mRNA.
DR EMBL; AC117456; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW78424.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78426.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78425.1; -; Genomic_DNA.
DR EMBL; BC002896; AAH02896.1; -; mRNA.
DR CCDS; CCDS3224.1; -. [Q9HA38-1]
DR CCDS; CCDS46962.1; -. [Q9HA38-2]
DR RefSeq; NP_071915.1; NM_022470.3. [Q9HA38-1]
DR RefSeq; NP_689426.1; NM_152240.2. [Q9HA38-2]
DR RefSeq; XP_005247763.1; XM_005247706.2.
DR RefSeq; XP_011511375.1; XM_011513073.1. [Q9HA38-1]
DR AlphaFoldDB; Q9HA38; -.
DR SMR; Q9HA38; -.
DR BioGRID; 122151; 31.
DR IntAct; Q9HA38; 22.
DR MINT; Q9HA38; -.
DR STRING; 9606.ENSP00000311221; -.
DR iPTMnet; Q9HA38; -.
DR PhosphoSitePlus; Q9HA38; -.
DR BioMuta; ZMAT3; -.
DR DMDM; 74734128; -.
DR EPD; Q9HA38; -.
DR MassIVE; Q9HA38; -.
DR MaxQB; Q9HA38; -.
DR PaxDb; Q9HA38; -.
DR PeptideAtlas; Q9HA38; -.
DR PRIDE; Q9HA38; -.
DR ProteomicsDB; 81372; -. [Q9HA38-1]
DR ProteomicsDB; 81373; -. [Q9HA38-2]
DR Antibodypedia; 18760; 204 antibodies from 32 providers.
DR DNASU; 64393; -.
DR Ensembl; ENST00000311417.7; ENSP00000311221.2; ENSG00000172667.11. [Q9HA38-1]
DR Ensembl; ENST00000432729.5; ENSP00000396506.1; ENSG00000172667.11. [Q9HA38-2]
DR GeneID; 64393; -.
DR KEGG; hsa:64393; -.
DR MANE-Select; ENST00000311417.7; ENSP00000311221.2; NM_022470.4; NP_071915.1.
DR UCSC; uc003fjg.5; human. [Q9HA38-1]
DR CTD; 64393; -.
DR DisGeNET; 64393; -.
DR GeneCards; ZMAT3; -.
DR HGNC; HGNC:29983; ZMAT3.
DR HPA; ENSG00000172667; Low tissue specificity.
DR MIM; 606452; gene.
DR neXtProt; NX_Q9HA38; -.
DR OpenTargets; ENSG00000172667; -.
DR PharmGKB; PA145147560; -.
DR VEuPathDB; HostDB:ENSG00000172667; -.
DR eggNOG; ENOG502QW4K; Eukaryota.
DR GeneTree; ENSGT00730000111202; -.
DR HOGENOM; CLU_051920_1_0_1; -.
DR InParanoid; Q9HA38; -.
DR OMA; QAHYRGK; -.
DR OrthoDB; 1565630at2759; -.
DR PhylomeDB; Q9HA38; -.
DR TreeFam; TF350019; -.
DR PathwayCommons; Q9HA38; -.
DR SignaLink; Q9HA38; -.
DR BioGRID-ORCS; 64393; 13 hits in 1089 CRISPR screens.
DR ChiTaRS; ZMAT3; human.
DR GenomeRNAi; 64393; -.
DR Pharos; Q9HA38; Tbio.
DR PRO; PR:Q9HA38; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9HA38; protein.
DR Bgee; ENSG00000172667; Expressed in postcentral gyrus and 192 other tissues.
DR ExpressionAtlas; Q9HA38; baseline and differential.
DR Genevisible; Q9HA38; HS.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR022755; Znf_C2H2_jaz.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF12171; zf-C2H2_jaz; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SMART; SM00451; ZnF_U1; 3.
DR SUPFAM; SSF57667; SSF57667; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Apoptosis; DNA damage; Growth regulation;
KW Metal-binding; Nucleus; Protein transport; Reference proteome; Repeat;
KW RNA-binding; Translocation; Transport; Zinc; Zinc-finger.
FT CHAIN 1..289
FT /note="Zinc finger matrin-type protein 3"
FT /id="PRO_0000310779"
FT ZN_FING 70..100
FT /note="Matrin-type 1"
FT /evidence="ECO:0000255"
FT ZN_FING 147..177
FT /note="Matrin-type 2"
FT /evidence="ECO:0000255"
FT ZN_FING 246..276
FT /note="Matrin-type 3"
FT /evidence="ECO:0000255"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 220
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11571644,
FT ECO:0000303|PubMed:11689294, ECO:0000303|PubMed:14702039"
FT /id="VSP_040093"
SQ SEQUENCE 289 AA; 32059 MW; CF3CAB0AA51DDD29 CRC64;
MILLQHAVLP PPKQPSPSPP MSVATRSTGT LQLPPQKPFG QEASLPLAGE EELSKGGEQD
CALEELCKPL YCKLCNVTLN SAQQAQAHYQ GKNHGKKLRN YYAANSCPPP ARMSNVVEPA
ATPVVPVPPQ MGSFKPGGRV ILATENDYCK LCDASFSSPA VAQAHYQGKN HAKRLRLAEA
QSNSFSESSE LGQRRARKEG NEFKMMPNRR NMYTVQNNSA GPYFNPRSRQ RIPRDLAMCV
TPSGQFYCSM CNVGAGEEME FRQHLESKQH KSKVSEQRYR NEMENLGYV
