ZMAT4_HUMAN
ID ZMAT4_HUMAN Reviewed; 229 AA.
AC Q9H898; Q8WUT8;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Zinc finger matrin-type protein 4;
GN Name=ZMAT4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Thyroid;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT ALA-201.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9H898; Q13618: CUL3; NbExp=3; IntAct=EBI-2548542, EBI-456129;
CC Q9H898-2; P78563-4: ADARB1; NbExp=3; IntAct=EBI-11529334, EBI-12002366;
CC Q9H898-2; Q13618: CUL3; NbExp=3; IntAct=EBI-11529334, EBI-456129;
CC Q9H898-2; Q13620: CUL4B; NbExp=3; IntAct=EBI-11529334, EBI-456067;
CC Q9H898-2; Q6UWE0: LRSAM1; NbExp=3; IntAct=EBI-11529334, EBI-720984;
CC Q9H898-2; O75569: PRKRA; NbExp=4; IntAct=EBI-11529334, EBI-713955;
CC Q9H898-2; A0A0S2Z5K8: STRBP; NbExp=3; IntAct=EBI-11529334, EBI-16433759;
CC Q9H898-2; Q96SI9: STRBP; NbExp=3; IntAct=EBI-11529334, EBI-740355;
CC Q9H898-2; Q15633: TARBP2; NbExp=3; IntAct=EBI-11529334, EBI-978581;
CC Q9H898-2; Q9H898-2: ZMAT4; NbExp=3; IntAct=EBI-11529334, EBI-11529334;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9H898-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H898-2; Sequence=VSP_027476;
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DR EMBL; AK023904; BAB14719.1; -; mRNA.
DR EMBL; BC019598; AAH19598.1; -; mRNA.
DR CCDS; CCDS34885.1; -. [Q9H898-1]
DR CCDS; CCDS47848.1; -. [Q9H898-2]
DR RefSeq; NP_001129203.1; NM_001135731.1. [Q9H898-2]
DR RefSeq; NP_078921.1; NM_024645.2. [Q9H898-1]
DR AlphaFoldDB; Q9H898; -.
DR SMR; Q9H898; -.
DR BioGRID; 122819; 31.
DR IntAct; Q9H898; 23.
DR STRING; 9606.ENSP00000297737; -.
DR iPTMnet; Q9H898; -.
DR PhosphoSitePlus; Q9H898; -.
DR BioMuta; ZMAT4; -.
DR DMDM; 74733790; -.
DR EPD; Q9H898; -.
DR jPOST; Q9H898; -.
DR MassIVE; Q9H898; -.
DR PaxDb; Q9H898; -.
DR PeptideAtlas; Q9H898; -.
DR PRIDE; Q9H898; -.
DR ProteomicsDB; 81200; -. [Q9H898-1]
DR ProteomicsDB; 81201; -. [Q9H898-2]
DR Antibodypedia; 23910; 157 antibodies from 18 providers.
DR DNASU; 79698; -.
DR Ensembl; ENST00000297737.11; ENSP00000297737.6; ENSG00000165061.15. [Q9H898-1]
DR Ensembl; ENST00000315769.11; ENSP00000319785.7; ENSG00000165061.15. [Q9H898-2]
DR GeneID; 79698; -.
DR KEGG; hsa:79698; -.
DR MANE-Select; ENST00000297737.11; ENSP00000297737.6; NM_024645.3; NP_078921.1.
DR UCSC; uc003xnr.5; human. [Q9H898-1]
DR CTD; 79698; -.
DR DisGeNET; 79698; -.
DR GeneCards; ZMAT4; -.
DR HGNC; HGNC:25844; ZMAT4.
DR HPA; ENSG00000165061; Group enriched (brain, retina, thyroid gland).
DR neXtProt; NX_Q9H898; -.
DR OpenTargets; ENSG00000165061; -.
DR PharmGKB; PA142670525; -.
DR VEuPathDB; HostDB:ENSG00000165061; -.
DR eggNOG; ENOG502QTR6; Eukaryota.
DR GeneTree; ENSGT00940000156888; -.
DR HOGENOM; CLU_056875_2_0_1; -.
DR InParanoid; Q9H898; -.
DR OMA; RVAHYEX; -.
DR OrthoDB; 1565630at2759; -.
DR PhylomeDB; Q9H898; -.
DR TreeFam; TF350019; -.
DR PathwayCommons; Q9H898; -.
DR SignaLink; Q9H898; -.
DR BioGRID-ORCS; 79698; 16 hits in 1075 CRISPR screens.
DR ChiTaRS; ZMAT4; human.
DR GenomeRNAi; 79698; -.
DR Pharos; Q9H898; Tdark.
DR PRO; PR:Q9H898; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q9H898; protein.
DR Bgee; ENSG00000165061; Expressed in middle temporal gyrus and 120 other tissues.
DR ExpressionAtlas; Q9H898; baseline and differential.
DR Genevisible; Q9H898; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR022755; Znf_C2H2_jaz.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF12171; zf-C2H2_jaz; 2.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SMART; SM00451; ZnF_U1; 4.
DR SUPFAM; SSF57667; SSF57667; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..229
FT /note="Zinc finger matrin-type protein 4"
FT /id="PRO_0000298916"
FT ZN_FING 14..44
FT /note="Matrin-type 1"
FT ZN_FING 72..106
FT /note="Matrin-type 2"
FT ZN_FING 145..175
FT /note="Matrin-type 3"
FT ZN_FING 198..228
FT /note="Matrin-type 4"
FT REGION 116..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 117..192
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027476"
FT VARIANT 201
FT /note="T -> A (in dbSNP:rs17851751)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_034736"
SQ SEQUENCE 229 AA; 25833 MW; DB60004B797EEEFB CRC64;
MKSSDIDQDL FTDSYCKVCS AQLISESQRV AHYESRKHAS KVRLYYMLHP RDGGCPAKRL
RSENGSDADM VDKNKCCTLC NMSFTSAVVA DSHYQGKIHA KRLKLLLGEK TPLKTTATPL
SPLKPPRMDT APVVASPYQR RDSDRYCGLC AAWFNNPLMA QQHYDGKKHK KNAARVALLE
QLGTTLDMGE LRGLRRNYRC TICSVSLNSI EQYHAHLKGS KHQTNLKNK
