ZMAT4_MOUSE
ID ZMAT4_MOUSE Reviewed; 229 AA.
AC Q8BZ94; Q3USG2; Q6AXC5;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Zinc finger matrin-type protein 4;
GN Name=Zmat4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00130}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8BZ94-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BZ94-2; Sequence=VSP_027477;
CC Name=3;
CC IsoId=Q8BZ94-3; Sequence=VSP_027478;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK036254; BAC29363.1; -; mRNA.
DR EMBL; AK134793; BAE22287.1; -; mRNA.
DR EMBL; AK140391; BAE24370.1; -; mRNA.
DR EMBL; AK140413; BAE24377.1; -; mRNA.
DR EMBL; BC065110; AAH65110.1; -; mRNA.
DR EMBL; BC079657; AAH79657.1; -; mRNA.
DR CCDS; CCDS22192.1; -. [Q8BZ94-1]
DR CCDS; CCDS85514.1; -. [Q8BZ94-3]
DR RefSeq; NP_001264168.1; NM_001277239.1. [Q8BZ94-3]
DR RefSeq; NP_796060.1; NM_177086.4. [Q8BZ94-1]
DR RefSeq; XP_006509203.1; XM_006509140.3. [Q8BZ94-1]
DR RefSeq; XP_006509204.1; XM_006509141.2. [Q8BZ94-1]
DR RefSeq; XP_011240443.1; XM_011242141.2. [Q8BZ94-1]
DR RefSeq; XP_011240444.1; XM_011242142.2. [Q8BZ94-1]
DR RefSeq; XP_017168347.1; XM_017312858.1. [Q8BZ94-1]
DR AlphaFoldDB; Q8BZ94; -.
DR SMR; Q8BZ94; -.
DR STRING; 10090.ENSMUSP00000049430; -.
DR PhosphoSitePlus; Q8BZ94; -.
DR PaxDb; Q8BZ94; -.
DR PeptideAtlas; Q8BZ94; -.
DR PRIDE; Q8BZ94; -.
DR ProteomicsDB; 274994; -. [Q8BZ94-1]
DR ProteomicsDB; 274995; -. [Q8BZ94-2]
DR ProteomicsDB; 274996; -. [Q8BZ94-3]
DR Antibodypedia; 23910; 157 antibodies from 18 providers.
DR DNASU; 320158; -.
DR Ensembl; ENSMUST00000042352; ENSMUSP00000049430; ENSMUSG00000037492. [Q8BZ94-1]
DR Ensembl; ENSMUST00000123412; ENSMUSP00000121626; ENSMUSG00000037492. [Q8BZ94-2]
DR Ensembl; ENSMUST00000207301; ENSMUSP00000146734; ENSMUSG00000037492. [Q8BZ94-3]
DR GeneID; 320158; -.
DR KEGG; mmu:320158; -.
DR UCSC; uc009lew.3; mouse. [Q8BZ94-1]
DR CTD; 79698; -.
DR MGI; MGI:2443497; Zmat4.
DR VEuPathDB; HostDB:ENSMUSG00000037492; -.
DR eggNOG; ENOG502QTR6; Eukaryota.
DR GeneTree; ENSGT00940000156888; -.
DR HOGENOM; CLU_056875_1_0_1; -.
DR InParanoid; Q8BZ94; -.
DR OMA; RVAHYEX; -.
DR OrthoDB; 1565630at2759; -.
DR PhylomeDB; Q8BZ94; -.
DR TreeFam; TF350019; -.
DR BioGRID-ORCS; 320158; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Zmat4; mouse.
DR PRO; PR:Q8BZ94; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8BZ94; protein.
DR Bgee; ENSMUSG00000037492; Expressed in medial dorsal nucleus of thalamus and 161 other tissues.
DR ExpressionAtlas; Q8BZ94; baseline and differential.
DR Genevisible; Q8BZ94; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR000690; Matrin/U1-C_Znf_C2H2.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR022755; Znf_C2H2_jaz.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF12171; zf-C2H2_jaz; 2.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SMART; SM00451; ZnF_U1; 4.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS50171; ZF_MATRIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..229
FT /note="Zinc finger matrin-type protein 4"
FT /id="PRO_0000298917"
FT ZN_FING 14..44
FT /note="Matrin-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00130"
FT ZN_FING 72..106
FT /note="Matrin-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00130"
FT ZN_FING 145..175
FT /note="Matrin-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00130"
FT ZN_FING 198..228
FT /note="Matrin-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00130"
FT VAR_SEQ 1..69
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027478"
FT VAR_SEQ 225..229
FT /note="NLKNK -> K (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027477"
SQ SEQUENCE 229 AA; 25671 MW; 86CDD773A5C08937 CRC64;
MKSSDIDQDL FTDSYCKVCS AQLISESQRV AHYESRKHAS KVRLYYMLHP RDGGCPAKRL
RAENGSDADM VDKNKCCTLC NMSFTSAVVA DSHYQGKIHA KRLKLLLGEK PPLKTTAAPL
SSLKAPRVDT APVVASPYQR RDSDRYCGLC AAWFNNPLMA QQHYEGKKHK KNAARVALLE
QLGTSLDLGE LRGLRRTYRC TTCSVSLNSI EQYHAHLQGS KHQTNLKNK
