ZMAT5_HUMAN
ID ZMAT5_HUMAN Reviewed; 170 AA.
AC Q9UDW3; A8K9F6;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Zinc finger matrin-type protein 5;
DE AltName: Full=U11/U12 small nuclear ribonucleoprotein 20 kDa protein;
DE Short=U11/U12 snRNP 20 kDa protein;
DE Short=U11/U12-20K;
GN Name=ZMAT5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION IN A COMPLEX WITH THE U11/U12 SPLICEOSOME, SUBCELLULAR
RP LOCATION, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=15146077; DOI=10.1261/rna.7320604;
RA Will C.L., Schneider C., Hossbach M., Urlaub H., Rauhut R., Elbashir S.,
RA Tuschl T., Luehrmann R.;
RT "The human 18S U11/U12 snRNP contains a set of novel proteins not found in
RT the U2-dependent spliceosome.";
RL RNA 10:929-941(2004).
CC -!- SUBUNIT: Component of the U11/U12 snRNPs that are part of the U12-type
CC spliceosome. Not found in the major spliceosome.
CC {ECO:0000269|PubMed:15146077}.
CC -!- INTERACTION:
CC Q9UDW3; Q9H6L4: ARMC7; NbExp=3; IntAct=EBI-7850213, EBI-742909;
CC Q9UDW3; Q13895: BYSL; NbExp=3; IntAct=EBI-7850213, EBI-358049;
CC Q9UDW3; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-7850213, EBI-8643161;
CC Q9UDW3; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-7850213, EBI-744556;
CC Q9UDW3; Q02930-3: CREB5; NbExp=3; IntAct=EBI-7850213, EBI-10192698;
CC Q9UDW3; Q9NW38: FANCL; NbExp=3; IntAct=EBI-7850213, EBI-2339898;
CC Q9UDW3; P55040: GEM; NbExp=3; IntAct=EBI-7850213, EBI-744104;
CC Q9UDW3; O95872: GPANK1; NbExp=3; IntAct=EBI-7850213, EBI-751540;
CC Q9UDW3; P31273: HOXC8; NbExp=3; IntAct=EBI-7850213, EBI-1752118;
CC Q9UDW3; P40692: MLH1; NbExp=3; IntAct=EBI-7850213, EBI-744248;
CC Q9UDW3; Q8WWB5: PIH1D2; NbExp=3; IntAct=EBI-7850213, EBI-10232538;
CC Q9UDW3; Q6IQ23-2: PLEKHA7; NbExp=3; IntAct=EBI-7850213, EBI-12069346;
CC Q9UDW3; Q6ZRY4: RBPMS2; NbExp=3; IntAct=EBI-7850213, EBI-11987469;
CC Q9UDW3; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-7850213, EBI-358489;
CC Q9UDW3; Q9BT92: TCHP; NbExp=3; IntAct=EBI-7850213, EBI-740781;
CC Q9UDW3; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-7850213, EBI-725997;
CC Q9UDW3; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-7850213, EBI-2559305;
CC Q9UDW3; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-7850213, EBI-740727;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15146077}.
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DR EMBL; AL160311; CAB77284.1; -; mRNA.
DR EMBL; CR456353; CAG30239.1; -; mRNA.
DR EMBL; CR457393; CAG33674.1; -; mRNA.
DR EMBL; AK292671; BAF85360.1; -; mRNA.
DR EMBL; CH471095; EAW59837.1; -; Genomic_DNA.
DR EMBL; BC009717; AAH09717.1; -; mRNA.
DR EMBL; BK005198; DAA05496.1; -; mRNA.
DR CCDS; CCDS13868.1; -.
DR RefSeq; NP_001003692.1; NM_001003692.1.
DR RefSeq; NP_001305058.1; NM_001318129.1.
DR RefSeq; NP_061976.1; NM_019103.2.
DR AlphaFoldDB; Q9UDW3; -.
DR SMR; Q9UDW3; -.
DR BioGRID; 121007; 59.
DR CORUM; Q9UDW3; -.
DR IntAct; Q9UDW3; 37.
DR MINT; Q9UDW3; -.
DR STRING; 9606.ENSP00000344241; -.
DR iPTMnet; Q9UDW3; -.
DR PhosphoSitePlus; Q9UDW3; -.
DR BioMuta; ZMAT5; -.
DR DMDM; 74753269; -.
DR EPD; Q9UDW3; -.
DR MassIVE; Q9UDW3; -.
DR MaxQB; Q9UDW3; -.
DR PaxDb; Q9UDW3; -.
DR PeptideAtlas; Q9UDW3; -.
DR PRIDE; Q9UDW3; -.
DR ProteomicsDB; 84122; -.
DR Antibodypedia; 330; 60 antibodies from 13 providers.
DR DNASU; 55954; -.
DR Ensembl; ENST00000344318.4; ENSP00000344241.3; ENSG00000100319.13.
DR GeneID; 55954; -.
DR KEGG; hsa:55954; -.
DR MANE-Select; ENST00000344318.4; ENSP00000344241.3; NM_001003692.2; NP_001003692.1.
DR UCSC; uc003agn.4; human.
DR CTD; 55954; -.
DR DisGeNET; 55954; -.
DR GeneCards; ZMAT5; -.
DR HGNC; HGNC:28046; ZMAT5.
DR HPA; ENSG00000100319; Low tissue specificity.
DR MIM; 619741; gene.
DR neXtProt; NX_Q9UDW3; -.
DR PharmGKB; PA142670524; -.
DR VEuPathDB; HostDB:ENSG00000100319; -.
DR eggNOG; KOG3454; Eukaryota.
DR GeneTree; ENSGT00390000009869; -.
DR HOGENOM; CLU_100385_1_0_1; -.
DR InParanoid; Q9UDW3; -.
DR OMA; WPPIQEL; -.
DR OrthoDB; 1541869at2759; -.
DR PhylomeDB; Q9UDW3; -.
DR TreeFam; TF332784; -.
DR PathwayCommons; Q9UDW3; -.
DR Reactome; R-HSA-72165; mRNA Splicing - Minor Pathway.
DR SignaLink; Q9UDW3; -.
DR BioGRID-ORCS; 55954; 593 hits in 1079 CRISPR screens.
DR ChiTaRS; ZMAT5; human.
DR GenomeRNAi; 55954; -.
DR Pharos; Q9UDW3; Tdark.
DR PRO; PR:Q9UDW3; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q9UDW3; protein.
DR Bgee; ENSG00000100319; Expressed in hindlimb stylopod muscle and 120 other tissues.
DR ExpressionAtlas; Q9UDW3; baseline and differential.
DR Genevisible; Q9UDW3; HS.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005689; C:U12-type spliceosomal complex; IDA:HGNC-UCL.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IC:HGNC-UCL.
DR InterPro; IPR013085; U1-CZ_Znf_C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR Pfam; PF00642; zf-CCCH; 1.
DR Pfam; PF06220; zf-U1; 1.
DR SMART; SM00356; ZnF_C3H1; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR SUPFAM; SSF90229; SSF90229; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 1: Evidence at protein level;
KW Metal-binding; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Spliceosome; Zinc; Zinc-finger.
FT CHAIN 1..170
FT /note="Zinc finger matrin-type protein 5"
FT /id="PRO_0000254114"
FT ZN_FING 51..79
FT /note="C3H1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT REGION 150..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 170 AA; 19971 MW; FEBF7BD946EFA5FA CRC64;
MGKRYFCDYC DRSFQDNLHN RKKHLNGLQH LKAKKVWYDM FRDAAAILLD EQNKRPCRKF
LLTGQCDFGS NCRFSHMSER DLQELSIQVE EERRAREWLL DAPELPEGHL EDWLEKRAKR
LSSAPSSRAE PIRTTVFQYP VGWPPVQELP PSLRAPPPGG WPLQPRVQWG
