ZMIZ2_HUMAN
ID ZMIZ2_HUMAN Reviewed; 920 AA.
AC Q8NF64; A4D2K7; D3DVL1; O94790; Q0VGB4; Q659A8; Q6JKL5; Q8WTX8; Q96Q01;
AC Q9BQH7;
DT 07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Zinc finger MIZ domain-containing protein 2;
DE AltName: Full=PIAS-like protein Zimp7;
GN Name=ZMIZ2; Synonyms=KIAA1886, ZIMP7; ORFNames=HRIHFB2007;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH AR;
RP SMARCA4 AND SMARCE1, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=16051670; DOI=10.1210/me.2005-0097;
RA Huang C.-Y., Beliakoff J., Li X., Lee J., Li X., Sharma M., Lim B., Sun Z.;
RT "hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated
RT transcription and interacts with SWI/SNF-like BAF complexes.";
RL Mol. Endocrinol. 19:2915-2929(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT PHE-408.
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 316-920 (ISOFORM 1).
RC TISSUE=Kidney, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 240-920 (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=11572484; DOI=10.1093/dnares/8.4.179;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXI. The
RT complete sequences of 60 new cDNA clones from brain which code for large
RT proteins.";
RL DNA Res. 8:179-187(2001).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 332-920.
RC TISSUE=Amygdala, and Fetal brain;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 668-920, AND SUBCELLULAR
RP LOCATION.
RC TISSUE=Fetal brain;
RX PubMed=9853615; DOI=10.1038/4315;
RA Ueki N., Oda T., Kondo M., Yano K., Noguchi T., Muramatsu M.-A.;
RT "Selection system for genes encoding nuclear-targeted proteins.";
RL Nat. Biotechnol. 16:1338-1342(1998).
RN [10]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-245 AND ARG-262, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Colon carcinoma;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
RN [11]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-402, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25772364; DOI=10.1016/j.celrep.2015.02.033;
RA Hendriks I.A., Treffers L.W., Verlaan-de Vries M., Olsen J.V.,
RA Vertegaal A.C.;
RT "SUMO-2 orchestrates chromatin modifiers in response to DNA damage.";
RL Cell Rep. 10:1778-1791(2015).
RN [12]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-402; LYS-457 AND LYS-692, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: Increases ligand-dependent transcriptional activity of AR and
CC other nuclear hormone receptors. {ECO:0000269|PubMed:16051670}.
CC -!- SUBUNIT: Interacts with AR, SMARCA4/BRG1 and SMARCE1/BAF57. Interaction
CC with either SMARCA4 and SMARCE1 enhances AR-mediated transcription.
CC {ECO:0000269|PubMed:16051670}.
CC -!- INTERACTION:
CC Q8NF64; Q8N5N6: ARSJ; NbExp=3; IntAct=EBI-745786, EBI-10266832;
CC Q8NF64; A0A0S2Z5G4: BANP; NbExp=3; IntAct=EBI-745786, EBI-16429704;
CC Q8NF64; B4DE54: BANP; NbExp=3; IntAct=EBI-745786, EBI-16429313;
CC Q8NF64; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-745786, EBI-11524452;
CC Q8NF64; Q8N9N5-7: BANP; NbExp=3; IntAct=EBI-745786, EBI-16429296;
CC Q8NF64; O75575: CRCP; NbExp=3; IntAct=EBI-745786, EBI-2654687;
CC Q8NF64; O00629: KPNA4; NbExp=3; IntAct=EBI-745786, EBI-396343;
CC Q8NF64; Q13526: PIN1; NbExp=4; IntAct=EBI-745786, EBI-714158;
CC Q8NF64-2; Q8N5N6: ARSJ; NbExp=3; IntAct=EBI-10182121, EBI-10266832;
CC Q8NF64-2; Q8WXK3: ASB13; NbExp=3; IntAct=EBI-10182121, EBI-707573;
CC Q8NF64-2; Q8N9N5: BANP; NbExp=3; IntAct=EBI-10182121, EBI-744695;
CC Q8NF64-2; Q9BSF0: C2orf88; NbExp=3; IntAct=EBI-10182121, EBI-744298;
CC Q8NF64-2; O75575: CRCP; NbExp=3; IntAct=EBI-10182121, EBI-2654687;
CC Q8NF64-2; Q96HW7: INTS4; NbExp=3; IntAct=EBI-10182121, EBI-5663129;
CC Q8NF64-2; P41271: NBL1; NbExp=3; IntAct=EBI-10182121, EBI-10208650;
CC Q8NF64-2; Q13526: PIN1; NbExp=3; IntAct=EBI-10182121, EBI-714158;
CC Q8NF64-2; Q9Y467: SALL2; NbExp=3; IntAct=EBI-10182121, EBI-746180;
CC Q8NF64-2; O15126: SCAMP1; NbExp=3; IntAct=EBI-10182121, EBI-954338;
CC Q8NF64-2; P59797: SELENOV; NbExp=3; IntAct=EBI-10182121, EBI-10216195;
CC Q8NF64-2; Q16385: SSX2B; NbExp=3; IntAct=EBI-10182121, EBI-2210673;
CC Q8NF64-2; O75865: TRAPPC6A; NbExp=3; IntAct=EBI-10182121, EBI-743573;
CC Q8NF64-2; A0A384ME25; NbExp=3; IntAct=EBI-10182121, EBI-10211777;
CC Q8NF64-3; Q9UBL6-2: CPNE7; NbExp=3; IntAct=EBI-12011330, EBI-12012272;
CC Q8NF64-3; O43559: FRS3; NbExp=3; IntAct=EBI-12011330, EBI-725515;
CC Q8NF64-3; O75603: GCM2; NbExp=3; IntAct=EBI-12011330, EBI-10188645;
CC Q8NF64-3; Q13526: PIN1; NbExp=3; IntAct=EBI-12011330, EBI-714158;
CC Q8NF64-3; O75177-5: SS18L1; NbExp=3; IntAct=EBI-12011330, EBI-12035119;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16051670,
CC ECO:0000269|PubMed:9853615}. Note=Detected at replication foci
CC throughout S phase.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8NF64-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NF64-2; Sequence=VSP_012190;
CC Name=3;
CC IsoId=Q8NF64-3; Sequence=VSP_024918, VSP_012190;
CC -!- TISSUE SPECIFICITY: Expressed most abundantly in testis with lower
CC levels in heart, brain, pancreas, prostate and ovary.
CC {ECO:0000269|PubMed:16051670}.
CC -!- DOMAIN: The C-terminal proline-rich domain possesses a significant
CC intrinsic transcriptional activity. This activity is inhibited by the
CC N-terminus in the full-length protein.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH21924.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC03396.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAB66507.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY426594; AAR85526.1; -; mRNA.
DR EMBL; AK090415; BAC03396.1; ALT_INIT; mRNA.
DR EMBL; AC004859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC013436; AAP22368.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH236960; EAL23750.1; -; Genomic_DNA.
DR EMBL; CH471128; EAW61083.1; -; Genomic_DNA.
DR EMBL; CH471128; EAW61084.1; -; Genomic_DNA.
DR EMBL; CH471128; EAW61085.1; -; Genomic_DNA.
DR EMBL; BC021924; AAH21924.1; ALT_INIT; mRNA.
DR EMBL; BC110435; AAI10436.1; -; mRNA.
DR EMBL; AB067473; BAB67779.1; -; mRNA.
DR EMBL; AL831933; CAH56269.1; -; mRNA.
DR EMBL; AL136572; CAB66507.1; ALT_INIT; mRNA.
DR EMBL; AB015330; BAA34789.1; -; mRNA.
DR CCDS; CCDS43576.1; -. [Q8NF64-1]
DR CCDS; CCDS43577.1; -. [Q8NF64-2]
DR CCDS; CCDS75591.1; -. [Q8NF64-3]
DR RefSeq; NP_001287888.1; NM_001300959.1. [Q8NF64-3]
DR RefSeq; NP_113637.3; NM_031449.3. [Q8NF64-1]
DR RefSeq; NP_777589.2; NM_174929.2. [Q8NF64-2]
DR RefSeq; XP_005249926.1; XM_005249869.2. [Q8NF64-1]
DR RefSeq; XP_005249929.1; XM_005249872.2. [Q8NF64-2]
DR AlphaFoldDB; Q8NF64; -.
DR SMR; Q8NF64; -.
DR BioGRID; 123701; 43.
DR IntAct; Q8NF64; 35.
DR STRING; 9606.ENSP00000311778; -.
DR iPTMnet; Q8NF64; -.
DR PhosphoSitePlus; Q8NF64; -.
DR BioMuta; ZMIZ2; -.
DR DMDM; 56404909; -.
DR EPD; Q8NF64; -.
DR jPOST; Q8NF64; -.
DR MassIVE; Q8NF64; -.
DR MaxQB; Q8NF64; -.
DR PaxDb; Q8NF64; -.
DR PeptideAtlas; Q8NF64; -.
DR PRIDE; Q8NF64; -.
DR ProteomicsDB; 73263; -. [Q8NF64-1]
DR ProteomicsDB; 73264; -. [Q8NF64-2]
DR ProteomicsDB; 73265; -. [Q8NF64-3]
DR Antibodypedia; 27318; 105 antibodies from 23 providers.
DR DNASU; 83637; -.
DR Ensembl; ENST00000265346.11; ENSP00000265346.7; ENSG00000122515.16. [Q8NF64-2]
DR Ensembl; ENST00000309315.9; ENSP00000311778.4; ENSG00000122515.16. [Q8NF64-1]
DR Ensembl; ENST00000413916.5; ENSP00000409648.1; ENSG00000122515.16. [Q8NF64-3]
DR Ensembl; ENST00000441627.5; ENSP00000414723.1; ENSG00000122515.16. [Q8NF64-1]
DR GeneID; 83637; -.
DR KEGG; hsa:83637; -.
DR MANE-Select; ENST00000309315.9; ENSP00000311778.4; NM_031449.4; NP_113637.3.
DR UCSC; uc003tlq.4; human. [Q8NF64-1]
DR CTD; 83637; -.
DR DisGeNET; 83637; -.
DR GeneCards; ZMIZ2; -.
DR HGNC; HGNC:22229; ZMIZ2.
DR HPA; ENSG00000122515; Low tissue specificity.
DR MIM; 611196; gene.
DR neXtProt; NX_Q8NF64; -.
DR OpenTargets; ENSG00000122515; -.
DR PharmGKB; PA162409851; -.
DR VEuPathDB; HostDB:ENSG00000122515; -.
DR eggNOG; KOG2169; Eukaryota.
DR GeneTree; ENSGT01030000234539; -.
DR HOGENOM; CLU_009461_1_0_1; -.
DR InParanoid; Q8NF64; -.
DR OrthoDB; 273193at2759; -.
DR PhylomeDB; Q8NF64; -.
DR TreeFam; TF316952; -.
DR PathwayCommons; Q8NF64; -.
DR SignaLink; Q8NF64; -.
DR BioGRID-ORCS; 83637; 14 hits in 1100 CRISPR screens.
DR ChiTaRS; ZMIZ2; human.
DR GeneWiki; ZMIZ2; -.
DR GenomeRNAi; 83637; -.
DR Pharos; Q8NF64; Tbio.
DR PRO; PR:Q8NF64; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8NF64; protein.
DR Bgee; ENSG00000122515; Expressed in endothelial cell and 195 other tissues.
DR ExpressionAtlas; Q8NF64; baseline and differential.
DR Genevisible; Q8NF64; HS.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR GO; GO:0043596; C:nuclear replication fork; IDA:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IDA:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR004181; Znf_MIZ.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF02891; zf-MIZ; 1.
DR PROSITE; PS51044; ZF_SP_RING; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Isopeptide bond; Metal-binding; Methylation; Nucleus;
KW Reference proteome; Transcription; Transcription regulation;
KW Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..920
FT /note="Zinc finger MIZ domain-containing protein 2"
FT /id="PRO_0000218989"
FT ZN_FING 585..671
FT /note="SP-RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00452"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 54..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 435..506
FT /note="Interaction with AR"
FT /evidence="ECO:0000269|PubMed:16051670"
FT REGION 803..920
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..306
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..383
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 839..853
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 903..920
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 616
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00452"
FT BINDING 618
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00452"
FT BINDING 639
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00452"
FT BINDING 642
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00452"
FT MOD_RES 111
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q8CIE2"
FT MOD_RES 245
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 262
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT CROSSLNK 402
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:25772364,
FT ECO:0007744|PubMed:28112733"
FT CROSSLNK 457
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 692
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 56..87
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024918"
FT VAR_SEQ 334..359
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:11572484,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:16051670"
FT /id="VSP_012190"
FT VARIANT 408
FT /note="L -> F (in dbSNP:rs3735478)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_050536"
FT CONFLICT 127
FT /note="Missing (in Ref. 1; AAR85526)"
FT /evidence="ECO:0000305"
FT CONFLICT 462
FT /note="R -> RR (in Ref. 8; CAH56269)"
FT /evidence="ECO:0000305"
FT CONFLICT 568
FT /note="Missing (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 765
FT /note="T -> M (in Ref. 1, 6 and 8; CAB66507)"
FT /evidence="ECO:0000305"
FT CONFLICT 782
FT /note="S -> C (in Ref. 9)"
FT /evidence="ECO:0000305"
FT CONFLICT 799
FT /note="A -> V (in Ref. 9)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 920 AA; 96537 MW; C9CE99D0B0798B9F CRC64;
MNSMNPMKPA LPPAPHGDGS FAYESVPWQQ SATQPAGSLS VVTTVWGVGN ATQSQVLGNP
MGPAGSPSGS SMMPGVAGGS SALTSPQCLG QQAFAEGGAN KGYVQQGVYS RGGYPGAPGF
TTGYAGGPGG LGLPSHAARP STDFTQAAAA AAVAAAAATA TATATATVAA LQEKQSQELS
QYGAMGAGQS FNSQFLQHGG PRGPSVPAGM NPTGIGGVMG PSGLSPLAMN PTRAAGMTPL
YAGQRLPQHG YPGPPQAQPL PRQGVKRTYS EVYPGQQYLQ GGQYAPSTAQ FAPSPGQPPA
PSPSYPGHRL PLQQGMTQSL SVPGPTGLHY KPTEQFNGQG ASFNGGSVSY SQPGLSGPTR
SIPGYPSSPL PGNPTPPMTP SSSVPYMSPN QEVKSPFLPD LKPNLNSLHS SPSGSGPCDE
LRLTFPVRDG VVLEPFRLQH NLAVSNHVFQ LRDSVYKTLI MRPDLELQFK CYHHEDRQMN
TNWPASVQVS VNATPLTIER GDNKTSHKPL YLKHVCQPGR NTIQITVTAC CCSHLFVLQL
VHRPSVRSVL QGLLKKRLLP AEHCITKIKR NFSSGTIPGT PGPNGEDGVE QTAIKVSLKC
PITFRRIQLP ARGHDCRHIQ CFDLESYLQL NCERGTWRCP VCNKTALLEG LEVDQYMLGI
LIYIQNSDYE EITIDPTCSW KPVPVKPDMH IKEEPDGPAL KRCRTVSPAH VLMPSVMEMI
AALGPGAAPF APLQPPSVPA PSDYPGQGSS FLGPGTFPES FPPTTPSTPT LAEFTPGPPP
ISYQSDIPSS LLTSEKSTAC LPSQMAPAGH LDPTHNPGTP GLHTSNLGAP PGPQLHHSNP
PPASRQSLGQ ASLGPTGELA FSPATGVMGP PSMSGAGEAP EPALDLLPEL TNPDELLSYL
GPPDLPTNNN DDLLSLFENN
