CC21C_MOUSE
ID CC21C_MOUSE Reviewed; 133 AA.
AC P86793; O09002; O09006; P84443; Q5M8M5; Q91V84;
DT 11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=C-C motif chemokine 21c;
DE AltName: Full=6Ckine;
DE AltName: Full=Beta-chemokine exodus-2;
DE AltName: Full=Small-inducible cytokine A21c;
DE AltName: Full=Thymus-derived chemotactic agent 4;
DE Short=TCA4;
DE Flags: Precursor;
GN Name=Ccl21c; Synonyms=Scya21c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Ola;
RX PubMed=11123313; DOI=10.4049/jimmunol.166.1.361;
RA Nakano H., Gunn M.D.;
RT "Gene duplications at the chemokine locus on mouse chromosome 4: multiple
RT strain-specific haplotypes and the deletion of secondary lymphoid-organ
RT chemokine and EBI-1 ligand chemokine genes in the plt mutation.";
RL J. Immunol. 166:361-369(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP CHARACTERIZATION.
RX PubMed=9419363; DOI=10.1073/pnas.95.1.258;
RA Gunn M.D., Tangemann K., Tam C., Cyster J.G., Rosen S.D., Williams L.T.;
RT "A chemokine expressed in lymphoid high endothelial venules promotes the
RT adhesion and chemotaxis of naive T lymphocytes.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:258-263(1998).
CC -!- FUNCTION: Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic
CC in vitro for thymocytes and activated T-cells, but not for B-cells,
CC macrophages, or neutrophils. Potent mesangial cell chemoattractant.
CC Shows preferential activity towards naive T-cells. May play a role in
CC mediating homing of lymphocytes to secondary lymphoid organs.
CC -!- SUBUNIT: Binds to CCR7 and to CXCR3. Interacts with PDPN; relocalizes
CC PDPN to the basolateral membrane. {ECO:0000250|UniProtKB:O00585}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed strongly in lung, spleen, thymus,
CC peripheral and mesentric lymph nodes. Also expressed in the testis,
CC kidney, liver, and heart.
CC -!- MISCELLANEOUS: Three genes code for Ccl21 in mouse. Ccl21b and Ccl21c
CC produce identical proteins while the protein produced by Ccl21a differs
CC at only one position. Ccl21b and Ccl21c have Leu-65 (6Ckine-Leu) while
CC Ccl21a has 'Ser-65' (6Ckine-Ser).
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
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DR EMBL; AF307987; AAG45835.1; -; Genomic_DNA.
DR EMBL; AL844494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC087957; AAH87957.1; -; mRNA.
DR RefSeq; NP_001180595.1; NM_001193666.1.
DR RefSeq; NP_001180597.1; NM_001193668.1.
DR RefSeq; NP_001257289.1; NM_001270360.1.
DR RefSeq; NP_035465.2; NM_011335.2.
DR RefSeq; NP_075539.1; NM_023052.2.
DR RefSeq; XP_001473308.1; XM_001473258.5.
DR RefSeq; XP_001473444.1; XM_001473394.6.
DR AlphaFoldDB; P86793; -.
DR SMR; P86793; -.
DR PhosphoSitePlus; P86793; -.
DR jPOST; P86793; -.
DR MaxQB; P86793; -.
DR DNASU; 65956; -.
DR Ensembl; ENSMUST00000098123; ENSMUSP00000095727; ENSMUSG00000073878.
DR Ensembl; ENSMUST00000098128; ENSMUSP00000095732; ENSMUSG00000094065.
DR Ensembl; ENSMUST00000178168; ENSMUSP00000136903; ENSMUSG00000096596.
DR Ensembl; ENSMUST00000178864; ENSMUSP00000137149; ENSMUSG00000095675.
DR GeneID; 100042493; -.
DR GeneID; 100504239; -.
DR GeneID; 100504346; -.
DR GeneID; 100862177; -.
DR KEGG; mmu:100042493; -.
DR KEGG; mmu:100504239; -.
DR KEGG; mmu:100504346; -.
DR KEGG; mmu:100862177; -.
DR CTD; 100042493; -.
DR CTD; 100862177; -.
DR MGI; MGI:1891386; Ccl21c.
DR VEuPathDB; HostDB:ENSMUSG00000073878; -.
DR VEuPathDB; HostDB:ENSMUSG00000094065; -.
DR VEuPathDB; HostDB:ENSMUSG00000094121; -.
DR VEuPathDB; HostDB:ENSMUSG00000095675; -.
DR VEuPathDB; HostDB:ENSMUSG00000096271; -.
DR VEuPathDB; HostDB:ENSMUSG00000096596; -.
DR VEuPathDB; HostDB:ENSMUSG00000096873; -.
DR GeneTree; ENSGT01050000244920; -.
DR HOGENOM; CLU_141716_3_2_1; -.
DR OMA; THIVRSY; -.
DR OrthoDB; 1542802at2759; -.
DR PhylomeDB; P86793; -.
DR TreeFam; TF338224; -.
DR BioGRID-ORCS; 100042493; 4 hits in 32 CRISPR screens.
DR BioGRID-ORCS; 100504239; 0 hits in 8 CRISPR screens.
DR BioGRID-ORCS; 100504346; 0 hits in 9 CRISPR screens.
DR BioGRID-ORCS; 100862177; 1 hit in 18 CRISPR screens.
DR BioGRID-ORCS; 65956; 0 hits in 4 CRISPR screens.
DR PRO; PR:P86793; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; P86793; protein.
DR Bgee; ENSMUSG00000073878; Expressed in urinary bladder and 28 other tissues.
DR ExpressionAtlas; P86793; baseline.
DR Genevisible; P86793; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0031732; F:CCR7 chemokine receptor binding; IEA:InterPro.
DR GO; GO:0008009; F:chemokine activity; ISO:MGI.
DR GO; GO:0042379; F:chemokine receptor binding; ISO:MGI.
DR GO; GO:0090630; P:activation of GTPase activity; ISO:MGI.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:MGI.
DR GO; GO:0060326; P:cell chemotaxis; ISO:MGI.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0002407; P:dendritic cell chemotaxis; ISO:MGI.
DR GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR GO; GO:0001768; P:establishment of T cell polarity; ISO:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:MGI.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0031640; P:killing of cells of another organism; ISO:MGI.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0035759; P:mesangial cell-matrix adhesion; ISO:MGI.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:2000669; P:negative regulation of dendritic cell apoptotic process; ISO:MGI.
DR GO; GO:1903237; P:negative regulation of leukocyte tethering or rolling; ISO:MGI.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0030838; P:positive regulation of actin filament polymerization; ISO:MGI.
DR GO; GO:0033630; P:positive regulation of cell adhesion mediated by integrin; ISO:MGI.
DR GO; GO:2000147; P:positive regulation of cell motility; ISO:MGI.
DR GO; GO:0001954; P:positive regulation of cell-matrix adhesion; ISO:MGI.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:MGI.
DR GO; GO:0051491; P:positive regulation of filopodium assembly; ISO:MGI.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; ISO:MGI.
DR GO; GO:0046330; P:positive regulation of JNK cascade; ISO:MGI.
DR GO; GO:2000529; P:positive regulation of myeloid dendritic cell chemotaxis; ISO:MGI.
DR GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; ISO:MGI.
DR GO; GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; ISO:MGI.
DR GO; GO:0045860; P:positive regulation of protein kinase activity; ISO:MGI.
DR GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISO:MGI.
DR GO; GO:0031274; P:positive regulation of pseudopodium assembly; ISO:MGI.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; ISO:MGI.
DR GO; GO:0034695; P:response to prostaglandin E; ISO:MGI.
DR GO; GO:0031529; P:ruffle organization; ISO:MGI.
DR InterPro; IPR030593; CCL21.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR PANTHER; PTHR12015:SF72; PTHR12015:SF72; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
PE 1: Evidence at protein level;
KW Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..133
FT /note="C-C motif chemokine 21c"
FT /id="PRO_0000403422"
FT REGION 87..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 98..133
FT /note="C-terminal basic extension"
FT DISULFID 31..57
FT /evidence="ECO:0000250"
FT DISULFID 32..75
FT /evidence="ECO:0000250"
FT DISULFID 103..122
FT /evidence="ECO:0000255"
SQ SEQUENCE 133 AA; 14584 MW; 7071750A2089A70B CRC64;
MAQMMTLSLL SLVLALCIPW TQGSDGGGQD CCLKYSQKKI PYSIVRGYRK QEPSLGCPIP
AILFLPRKHS KPELCANPEE GWVQNLMRRL DQPPAPGKQS PGCRKNRGTS KSGKKGKGSK
GCKRTEQTQP SRG
