ZMY15_HUMAN
ID ZMY15_HUMAN Reviewed; 742 AA.
AC Q9H091; B4DXY5; I3L296;
DT 16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 25-JAN-2012, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Zinc finger MYND domain-containing protein 15;
GN Name=ZMYND15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP INVOLVEMENT IN SPGF14, AND POSSIBLE FUNCTION.
RX PubMed=24431330; DOI=10.1136/jmedgenet-2013-102102;
RA Ayhan O., Balkan M., Guven A., Hazan R., Atar M., Tok A., Tolun A.;
RT "Truncating mutations in TAF4B and ZMYND15 causing recessive azoospermia.";
RL J. Med. Genet. 51:239-244(2014).
CC -!- FUNCTION: Acts as a transcriptional repressor through interaction with
CC histone deacetylases (HDACs). May be important for spermiogenesis.
CC {ECO:0000250|UniProtKB:Q8C0R7, ECO:0000303|PubMed:24431330}.
CC -!- SUBUNIT: Interacts with HDAC1, HDAC3, HDAC6 and, to a lesser extent,
CC with HDAC7. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9H091-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H091-2; Sequence=VSP_042144;
CC Name=3;
CC IsoId=Q9H091-3; Sequence=VSP_047208;
CC -!- DISEASE: Spermatogenic failure 14 (SPGF14) [MIM:615842]: A disorder
CC resulting in the absence (azoospermia) or reduction (oligozoospermia)
CC of sperm in the semen, leading to male infertility.
CC {ECO:0000269|PubMed:24431330}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
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DR EMBL; AK302181; BAG63547.1; -; mRNA.
DR EMBL; AL136893; CAB66827.1; -; mRNA.
DR EMBL; AC091153; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471108; EAW90414.1; -; Genomic_DNA.
DR EMBL; BC067296; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS11053.1; -. [Q9H091-2]
DR CCDS; CCDS45584.1; -. [Q9H091-1]
DR CCDS; CCDS58506.1; -. [Q9H091-3]
DR RefSeq; NP_001129518.1; NM_001136046.2. [Q9H091-1]
DR RefSeq; NP_001254751.1; NM_001267822.1. [Q9H091-3]
DR RefSeq; NP_115641.1; NM_032265.2. [Q9H091-2]
DR AlphaFoldDB; Q9H091; -.
DR BioGRID; 123959; 1.
DR STRING; 9606.ENSP00000269289; -.
DR iPTMnet; Q9H091; -.
DR PhosphoSitePlus; Q9H091; -.
DR BioMuta; ZMYND15; -.
DR DMDM; 374095468; -.
DR MassIVE; Q9H091; -.
DR PaxDb; Q9H091; -.
DR PeptideAtlas; Q9H091; -.
DR PRIDE; Q9H091; -.
DR ProteomicsDB; 46881; -.
DR ProteomicsDB; 80218; -. [Q9H091-1]
DR ProteomicsDB; 80219; -. [Q9H091-2]
DR Antibodypedia; 11307; 16 antibodies from 9 providers.
DR DNASU; 84225; -.
DR Ensembl; ENST00000269289.10; ENSP00000269289.6; ENSG00000141497.14. [Q9H091-3]
DR Ensembl; ENST00000433935.6; ENSP00000391742.1; ENSG00000141497.14. [Q9H091-1]
DR Ensembl; ENST00000573751.2; ENSP00000459501.1; ENSG00000141497.14. [Q9H091-3]
DR Ensembl; ENST00000592813.5; ENSP00000465435.1; ENSG00000141497.14. [Q9H091-2]
DR GeneID; 84225; -.
DR KEGG; hsa:84225; -.
DR MANE-Select; ENST00000433935.6; ENSP00000391742.1; NM_001136046.3; NP_001129518.1.
DR UCSC; uc002fyt.4; human. [Q9H091-1]
DR CTD; 84225; -.
DR DisGeNET; 84225; -.
DR GeneCards; ZMYND15; -.
DR HGNC; HGNC:20997; ZMYND15.
DR HPA; ENSG00000141497; Tissue enriched (testis).
DR MalaCards; ZMYND15; -.
DR MIM; 614312; gene.
DR MIM; 615842; phenotype.
DR neXtProt; NX_Q9H091; -.
DR OpenTargets; ENSG00000141497; -.
DR Orphanet; 399805; Male infertility with azoospermia or oligozoospermia due to single gene mutation.
DR PharmGKB; PA134873463; -.
DR VEuPathDB; HostDB:ENSG00000141497; -.
DR eggNOG; KOG2084; Eukaryota.
DR GeneTree; ENSGT00390000000527; -.
DR HOGENOM; CLU_022430_0_0_1; -.
DR InParanoid; Q9H091; -.
DR OMA; GEGPALM; -.
DR OrthoDB; 290771at2759; -.
DR PhylomeDB; Q9H091; -.
DR TreeFam; TF336410; -.
DR PathwayCommons; Q9H091; -.
DR BioGRID-ORCS; 84225; 7 hits in 1065 CRISPR screens.
DR ChiTaRS; ZMYND15; human.
DR GenomeRNAi; 84225; -.
DR Pharos; Q9H091; Tdark.
DR PRO; PR:Q9H091; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q9H091; protein.
DR Bgee; ENSG00000141497; Expressed in left testis and 95 other tissues.
DR Genevisible; Q9H091; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0001673; C:male germ cell nucleus; IEA:Ensembl.
DR GO; GO:0042826; F:histone deacetylase binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0007286; P:spermatid development; IBA:GO_Central.
DR InterPro; IPR042989; ZMY15.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR47085; PTHR47085; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Differentiation; Metal-binding; Nucleus;
KW Reference proteome; Spermatogenesis; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..742
FT /note="Zinc finger MYND domain-containing protein 15"
FT /id="PRO_0000218317"
FT ZN_FING 313..359
FT /note="MYND-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT REGION 109..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..128
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..198
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..723
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 313
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 316
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 328
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 331
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 337
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 341
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 355
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 359
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT VAR_SEQ 460..499
FT /note="GSWQDYYTWRGLSLDSPIAVLLTYPLTVYYVITHLVPQSF -> V (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:11230166"
FT /id="VSP_042144"
FT VAR_SEQ 612
FT /note="I -> IASPSSLSA (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_047208"
FT VARIANT 401
FT /note="R -> H (in dbSNP:rs35005394)"
FT /id="VAR_052992"
SQ SEQUENCE 742 AA; 81860 MW; 88667EFB2B621CAF CRC64;
MEFVSGYRDE FLDFTALLFG WFRKFVAERG AVGTSLEGRC RQLEAQIRRL PQDPALWVLH
VLPNHSVGIS LGQGAEPGPG PGLGTAWLLG DNPPLHLRDL SPYISFVSLE DGEEGEEEEE
EDEEEEKRED GGAGSTEKVE PEEDRELAPT SRESPQETNP PGESEEAARE AGGGKDGCRE
DRVENETRPQ KRKGQRSEAA PLHVSCLLLV TDEHGTILGI DLLVDGAQGT ASWGSGTKDL
APWAYALLCH SMACPMGSGD PRKPRQLTVG DARLHRELES LVPRLGVKLA KTPMRTWGPR
PGFTFASLRA RTCHVCHRHS FEAKLTPCPQ CSAVLYCGEA CLRADWQRCP DDVSHRFWCP
RLAAFMERAG ELATLPFTYT AEVTSETFNK EAFLASRGLT RGYWTQLSML IPGPGFSRHP
RGNTPSLSLL RGGDPYQLLQ GDGTALMPPV PPHPPRGVFG SWQDYYTWRG LSLDSPIAVL
LTYPLTVYYV ITHLVPQSFP ELNIQNKQSL KIHVVEAGKE FDLVMVFWEL LVLLPHVALE
LQFVGDGLPP ESDEQHFTLQ RDSLEVSVRP GSGISARPSS GTKEKGGRRD LQIKVSARPY
HLFQGPKPDL VIGFNSGFAL KDTWLRSLPR LQSLRVPAFF TESSEYSCVM DGQTMAVATG
GGTSPPQPNP FRSPFRLRAA DNCMSWYCNA FIFHLVYKPA QGSGARPAPG PPPPSPTPSA
PPAPTRRRRG EKKPGRGARR RK
