ZMY19_HUMAN
ID ZMY19_HUMAN Reviewed; 227 AA.
AC Q96E35; Q5T366;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Zinc finger MYND domain-containing protein 19;
DE AltName: Full=Melanin-concentrating hormone receptor 1-interacting zinc finger protein;
DE Short=MCH-R1-interacting zinc finger protein;
GN Name=ZMYND19; Synonyms=MIZIP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND
RP INTERACTION WITH GPR24.
RC TISSUE=Brain;
RX PubMed=12208518; DOI=10.1016/s0014-5793(02)03115-0;
RA Baechner D., Kreienkamp H.-J., Richter D.;
RT "MIZIP, a highly conserved, vertebrate specific melanin-concentrating
RT hormone receptor 1 interacting zinc-finger protein.";
RL FEBS Lett. 526:124-128(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved as a regulatory molecule in GPR24/MCH-R1
CC signaling.
CC -!- SUBUNIT: Interacts with GPR24/MCH-R1. {ECO:0000269|PubMed:12208518}.
CC -!- INTERACTION:
CC Q96E35; Q9BTE6-2: AARSD1; NbExp=3; IntAct=EBI-746595, EBI-9357295;
CC Q96E35; Q3KP44: ANKRD55; NbExp=3; IntAct=EBI-746595, EBI-14493093;
CC Q96E35; Q5BKX5-3: C19orf54; NbExp=3; IntAct=EBI-746595, EBI-11976299;
CC Q96E35; Q9BRT8: CBWD1; NbExp=3; IntAct=EBI-746595, EBI-1054417;
CC Q96E35; Q5JTY5: CBWD3; NbExp=3; IntAct=EBI-746595, EBI-723434;
CC Q96E35; Q6NVZ8: CBWD5; NbExp=3; IntAct=EBI-746595, EBI-12928654;
CC Q96E35; Q14094: CCNI; NbExp=3; IntAct=EBI-746595, EBI-1104653;
CC Q96E35; P40199: CEACAM6; NbExp=3; IntAct=EBI-746595, EBI-4314501;
CC Q96E35; Q16630-2: CPSF6; NbExp=3; IntAct=EBI-746595, EBI-11088043;
CC Q96E35; Q8N9I9: DTX3; NbExp=3; IntAct=EBI-746595, EBI-2340258;
CC Q96E35; Q8TC92: ENOX1; NbExp=6; IntAct=EBI-746595, EBI-713221;
CC Q96E35; Q6UN15: FIP1L1; NbExp=3; IntAct=EBI-746595, EBI-1021914;
CC Q96E35; Q53EP0-3: FNDC3B; NbExp=3; IntAct=EBI-746595, EBI-10242151;
CC Q96E35; O14556: GAPDHS; NbExp=3; IntAct=EBI-746595, EBI-1057431;
CC Q96E35; Q86UU5: GGN; NbExp=3; IntAct=EBI-746595, EBI-10259069;
CC Q96E35; Q9UKD1: GMEB2; NbExp=3; IntAct=EBI-746595, EBI-948296;
CC Q96E35; Q9H8Y8: GORASP2; NbExp=3; IntAct=EBI-746595, EBI-739467;
CC Q96E35; Q13322-4: GRB10; NbExp=3; IntAct=EBI-746595, EBI-12353035;
CC Q96E35; Q14687: GSE1; NbExp=3; IntAct=EBI-746595, EBI-372619;
CC Q96E35; P13984: GTF2F2; NbExp=3; IntAct=EBI-746595, EBI-1030560;
CC Q96E35; Q9UJ83: HACL1; NbExp=7; IntAct=EBI-746595, EBI-746580;
CC Q96E35; Q0VD86: INCA1; NbExp=3; IntAct=EBI-746595, EBI-6509505;
CC Q96E35; Q8WZ19: KCTD13; NbExp=7; IntAct=EBI-746595, EBI-742916;
CC Q96E35; Q4G0X4: KCTD21; NbExp=3; IntAct=EBI-746595, EBI-11976683;
CC Q96E35; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-746595, EBI-1216080;
CC Q96E35; Q9BRK4: LZTS2; NbExp=4; IntAct=EBI-746595, EBI-741037;
CC Q96E35; P55198: MLLT6; NbExp=3; IntAct=EBI-746595, EBI-740216;
CC Q96E35; Q15742: NAB2; NbExp=7; IntAct=EBI-746595, EBI-8641936;
CC Q96E35; Q96PV4: PNMA5; NbExp=6; IntAct=EBI-746595, EBI-10171633;
CC Q96E35; O43741: PRKAB2; NbExp=5; IntAct=EBI-746595, EBI-1053424;
CC Q96E35; P31321: PRKAR1B; NbExp=3; IntAct=EBI-746595, EBI-2805516;
CC Q96E35; O14744: PRMT5; NbExp=3; IntAct=EBI-746595, EBI-351098;
CC Q96E35; P25786: PSMA1; NbExp=3; IntAct=EBI-746595, EBI-359352;
CC Q96E35; Q8HWS3: RFX6; NbExp=3; IntAct=EBI-746595, EBI-746118;
CC Q96E35; Q8IYX7: SAXO1; NbExp=6; IntAct=EBI-746595, EBI-3957636;
CC Q96E35; Q14524-3: SCN5A; NbExp=4; IntAct=EBI-746595, EBI-14276801;
CC Q96E35; P59797: SELENOV; NbExp=6; IntAct=EBI-746595, EBI-10216195;
CC Q96E35; O75177-5: SS18L1; NbExp=3; IntAct=EBI-746595, EBI-12035119;
CC Q96E35; Q3YBR2: TBRG1; NbExp=3; IntAct=EBI-746595, EBI-2800552;
CC Q96E35; Q13829: TNFAIP1; NbExp=3; IntAct=EBI-746595, EBI-2505861;
CC Q96E35; Q9H0E2: TOLLIP; NbExp=3; IntAct=EBI-746595, EBI-74615;
CC Q96E35; O94842: TOX4; NbExp=6; IntAct=EBI-746595, EBI-948613;
CC Q96E35; P14373: TRIM27; NbExp=3; IntAct=EBI-746595, EBI-719493;
CC Q96E35; Q9H8W5-2: TRIM45; NbExp=3; IntAct=EBI-746595, EBI-11993364;
CC Q96E35; Q8N680: ZBTB2; NbExp=3; IntAct=EBI-746595, EBI-2515601;
CC Q96E35; Q2QGD7: ZXDC; NbExp=3; IntAct=EBI-746595, EBI-1538838;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12208518}. Cell
CC membrane {ECO:0000269|PubMed:12208518}; Peripheral membrane protein
CC {ECO:0000269|PubMed:12208518}.
CC -!- TISSUE SPECIFICITY: Expressed in brain, testis, placenta, heart, liver,
CC skeletal muscle, kidney and stomach. {ECO:0000269|PubMed:12208518}.
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DR EMBL; AJ298882; CAC16691.1; -; mRNA.
DR EMBL; AL365502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC012948; AAH12948.1; -; mRNA.
DR CCDS; CCDS7048.1; -.
DR RefSeq; NP_612471.1; NM_138462.2.
DR AlphaFoldDB; Q96E35; -.
DR SMR; Q96E35; -.
DR BioGRID; 125490; 116.
DR IntAct; Q96E35; 74.
DR MINT; Q96E35; -.
DR STRING; 9606.ENSP00000298585; -.
DR iPTMnet; Q96E35; -.
DR PhosphoSitePlus; Q96E35; -.
DR BioMuta; ZMYND19; -.
DR DMDM; 46397255; -.
DR EPD; Q96E35; -.
DR jPOST; Q96E35; -.
DR MassIVE; Q96E35; -.
DR MaxQB; Q96E35; -.
DR PaxDb; Q96E35; -.
DR PeptideAtlas; Q96E35; -.
DR PRIDE; Q96E35; -.
DR ProteomicsDB; 76369; -.
DR Antibodypedia; 19078; 77 antibodies from 20 providers.
DR DNASU; 116225; -.
DR Ensembl; ENST00000298585.3; ENSP00000298585.2; ENSG00000165724.6.
DR GeneID; 116225; -.
DR KEGG; hsa:116225; -.
DR MANE-Select; ENST00000298585.3; ENSP00000298585.2; NM_138462.3; NP_612471.1.
DR UCSC; uc004cno.2; human.
DR CTD; 116225; -.
DR DisGeNET; 116225; -.
DR GeneCards; ZMYND19; -.
DR HGNC; HGNC:21146; ZMYND19.
DR HPA; ENSG00000165724; Tissue enriched (retina).
DR MIM; 611424; gene.
DR neXtProt; NX_Q96E35; -.
DR OpenTargets; ENSG00000165724; -.
DR PharmGKB; PA134878875; -.
DR VEuPathDB; HostDB:ENSG00000165724; -.
DR eggNOG; ENOG502QUSS; Eukaryota.
DR GeneTree; ENSGT00940000153820; -.
DR HOGENOM; CLU_084232_0_0_1; -.
DR InParanoid; Q96E35; -.
DR OMA; YAFEARV; -.
DR OrthoDB; 1254383at2759; -.
DR PhylomeDB; Q96E35; -.
DR TreeFam; TF329209; -.
DR PathwayCommons; Q96E35; -.
DR SignaLink; Q96E35; -.
DR BioGRID-ORCS; 116225; 18 hits in 1081 CRISPR screens.
DR ChiTaRS; ZMYND19; human.
DR GenomeRNAi; 116225; -.
DR Pharos; Q96E35; Tdark.
DR PRO; PR:Q96E35; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q96E35; protein.
DR Bgee; ENSG00000165724; Expressed in left testis and 162 other tissues.
DR Genevisible; Q96E35; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR044925; His-Me_finger_sf.
DR InterPro; IPR003615; HNH_nuc.
DR InterPro; IPR032978; ZMYND19.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR46831; PTHR46831; 1.
DR Pfam; PF13392; HNH_3; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR SUPFAM; SSF54060; SSF54060; 1.
DR PROSITE; PS01360; ZF_MYND_1; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cytoplasm; Membrane; Metal-binding; Reference proteome;
KW Zinc; Zinc-finger.
FT CHAIN 1..227
FT /note="Zinc finger MYND domain-containing protein 19"
FT /id="PRO_0000218319"
FT ZN_FING 174..212
FT /note="MYND-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 187
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 190
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 208
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 212
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
SQ SEQUENCE 227 AA; 26433 MW; 906F0B51B670063A CRC64;
MTDFKLGIVR LGRVAGKTKY TLIDEQDIPL VESYSFEARM EVDADGNGAK IFAYAFDKNR
GRGSGRLLHE LLWERHRGGV APGFQVVHLN AVTVDNRLDN LQLVPWGWRP KAEETSSKQR
EQSLYWLAIQ QLPTDPIEEQ FPVLNVTRYY NANGDVVEEE ENSCTYYECH YPPCTVIEKQ
LREFNICGRC QVARYCGSQC QQKDWPAHKK HCRERKRPFQ HELEPER
