ZMY19_MOUSE
ID ZMY19_MOUSE Reviewed; 227 AA.
AC Q9CQG3; Q8K1T3;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Zinc finger MYND domain-containing protein 19;
DE AltName: Full=Melanin-concentrating hormone receptor 1-interacting zinc finger protein;
DE Short=MCH-R1-interacting zinc finger protein;
GN Name=Zmynd19; Synonyms=Mizip;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=12208518; DOI=10.1016/s0014-5793(02)03115-0;
RA Baechner D., Kreienkamp H.-J., Richter D.;
RT "MIZIP, a highly conserved, vertebrate specific melanin-concentrating
RT hormone receptor 1 interacting zinc-finger protein.";
RL FEBS Lett. 526:124-128(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved as a regulatory molecule in GPR24/MCH-R1
CC signaling.
CC -!- SUBUNIT: Interacts with GPR24/MCH-R1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=MIZIPa;
CC IsoId=Q9CQG3-1; Sequence=Displayed;
CC Name=2; Synonyms=MIZIPb;
CC IsoId=Q9CQG3-2; Sequence=VSP_010075;
CC -!- TISSUE SPECIFICITY: Expressed in brain. {ECO:0000269|PubMed:12208518}.
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DR EMBL; AJ409150; CAC84079.1; -; mRNA.
DR EMBL; AJ409151; CAC84080.1; -; mRNA.
DR EMBL; AK005908; BAB24312.1; -; mRNA.
DR EMBL; AK012484; BAB28271.1; -; mRNA.
DR EMBL; BC027321; AAH27321.1; -; mRNA.
DR CCDS; CCDS15742.1; -. [Q9CQG3-1]
DR CCDS; CCDS79745.1; -. [Q9CQG3-2]
DR RefSeq; NP_080297.1; NM_026021.4. [Q9CQG3-1]
DR RefSeq; NP_671708.1; NM_147179.1. [Q9CQG3-2]
DR AlphaFoldDB; Q9CQG3; -.
DR SMR; Q9CQG3; -.
DR STRING; 10090.ENSMUSP00000028350; -.
DR iPTMnet; Q9CQG3; -.
DR PhosphoSitePlus; Q9CQG3; -.
DR EPD; Q9CQG3; -.
DR PaxDb; Q9CQG3; -.
DR PeptideAtlas; Q9CQG3; -.
DR PRIDE; Q9CQG3; -.
DR ProteomicsDB; 275374; -. [Q9CQG3-1]
DR ProteomicsDB; 275375; -. [Q9CQG3-2]
DR Antibodypedia; 19078; 77 antibodies from 20 providers.
DR DNASU; 67187; -.
DR Ensembl; ENSMUST00000028350; ENSMUSP00000028350; ENSMUSG00000026974. [Q9CQG3-1]
DR Ensembl; ENSMUST00000148042; ENSMUSP00000141788; ENSMUSG00000026974. [Q9CQG3-2]
DR GeneID; 67187; -.
DR KEGG; mmu:67187; -.
DR UCSC; uc008ipo.1; mouse. [Q9CQG3-1]
DR CTD; 116225; -.
DR MGI; MGI:1914437; Zmynd19.
DR VEuPathDB; HostDB:ENSMUSG00000026974; -.
DR eggNOG; ENOG502QUSS; Eukaryota.
DR GeneTree; ENSGT00940000153820; -.
DR HOGENOM; CLU_084232_0_0_1; -.
DR InParanoid; Q9CQG3; -.
DR OMA; YAFEARV; -.
DR OrthoDB; 1254383at2759; -.
DR PhylomeDB; Q9CQG3; -.
DR TreeFam; TF329209; -.
DR BioGRID-ORCS; 67187; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Zmynd19; mouse.
DR PRO; PR:Q9CQG3; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9CQG3; protein.
DR Bgee; ENSMUSG00000026974; Expressed in primary oocyte and 247 other tissues.
DR Genevisible; Q9CQG3; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IDA:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR044925; His-Me_finger_sf.
DR InterPro; IPR003615; HNH_nuc.
DR InterPro; IPR032978; ZMYND19.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR46831; PTHR46831; 1.
DR Pfam; PF13392; HNH_3; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR SUPFAM; SSF54060; SSF54060; 1.
DR PROSITE; PS01360; ZF_MYND_1; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Cytoplasm; Membrane; Metal-binding;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..227
FT /note="Zinc finger MYND domain-containing protein 19"
FT /id="PRO_0000218320"
FT ZN_FING 174..212
FT /note="MYND-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 187
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 190
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 208
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 212
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT VAR_SEQ 1..39
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12208518"
FT /id="VSP_010075"
SQ SEQUENCE 227 AA; 26433 MW; 906F0B51B670063A CRC64;
MTDFKLGIVR LGRVAGKTKY TLIDEQDIPL VESYSFEARM EVDADGNGAK IFAYAFDKNR
GRGSGRLLHE LLWERHRGGV APGFQVVHLN AVTVDNRLDN LQLVPWGWRP KAEETSSKQR
EQSLYWLAIQ QLPTDPIEEQ FPVLNVTRYY NANGDVVEEE ENSCTYYECH YPPCTVIEKQ
LREFNICGRC QVARYCGSQC QQKDWPAHKK HCRERKRPFQ HELEPER
