ID   ZMYM1_HUMAN             Reviewed;        1142 AA.
AC   Q5SVZ6; D3DPR7; Q7Z3Q4;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Zinc finger MYM-type protein 1;
GN   Name=ZMYM1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT MET-73.
RC   TISSUE=Heart;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT MET-73.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-25, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25755297; DOI=10.1074/mcp.o114.044792;
RA   Xiao Z., Chang J.G., Hendriks I.A., Sigurdsson J.O., Olsen J.V.,
RA   Vertegaal A.C.;
RT   "System-wide analysis of SUMOylation dynamics in response to replication
RT   stress reveals novel small ubiquitin-like modified target proteins and
RT   acceptor lysines relevant for genome stability.";
RL   Mol. Cell. Proteomics 14:1419-1434(2015).
RN   [5]
RP   SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-25 AND LYS-284, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=28112733; DOI=10.1038/nsmb.3366;
RA   Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA   Nielsen M.L.;
RT   "Site-specific mapping of the human SUMO proteome reveals co-modification
RT   with phosphorylation.";
RL   Nat. Struct. Mol. Biol. 24:325-336(2017).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; BX537537; CAD97777.1; -; mRNA.
DR   EMBL; AL607089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471059; EAX07428.1; -; Genomic_DNA.
DR   EMBL; CH471059; EAX07430.1; -; Genomic_DNA.
DR   CCDS; CCDS41302.1; -.
DR   RefSeq; NP_001276017.1; NM_001289088.1.
DR   RefSeq; NP_001276018.1; NM_001289089.1.
DR   RefSeq; NP_001276019.1; NM_001289090.1.
DR   RefSeq; NP_001306884.1; NM_001319955.1.
DR   RefSeq; NP_079048.3; NM_024772.4.
DR   AlphaFoldDB; Q5SVZ6; -.
DR   SMR; Q5SVZ6; -.
DR   BioGRID; 122922; 65.
DR   IntAct; Q5SVZ6; 47.
DR   MINT; Q5SVZ6; -.
DR   STRING; 9606.ENSP00000482579; -.
DR   iPTMnet; Q5SVZ6; -.
DR   PhosphoSitePlus; Q5SVZ6; -.
DR   BioMuta; ZMYM1; -.
DR   DMDM; 74743897; -.
DR   EPD; Q5SVZ6; -.
DR   jPOST; Q5SVZ6; -.
DR   MassIVE; Q5SVZ6; -.
DR   MaxQB; Q5SVZ6; -.
DR   PaxDb; Q5SVZ6; -.
DR   PeptideAtlas; Q5SVZ6; -.
DR   PRIDE; Q5SVZ6; -.
DR   ProteomicsDB; 63955; -.
DR   Antibodypedia; 57964; 38 antibodies from 18 providers.
DR   DNASU; 79830; -.
DR   Ensembl; ENST00000359858.9; ENSP00000352920.4; ENSG00000197056.11.
DR   Ensembl; ENST00000373330.1; ENSP00000362427.1; ENSG00000197056.11.
DR   Ensembl; ENST00000611874.4; ENSP00000482579.1; ENSG00000197056.11.
DR   Ensembl; ENST00000650449.1; ENSP00000496876.1; ENSG00000197056.11.
DR   GeneID; 79830; -.
DR   KEGG; hsa:79830; -.
DR   MANE-Select; ENST00000359858.9; ENSP00000352920.4; NM_024772.5; NP_079048.3.
DR   UCSC; uc001bym.5; human.
DR   CTD; 79830; -.
DR   DisGeNET; 79830; -.
DR   GeneCards; ZMYM1; -.
DR   HGNC; HGNC:26253; ZMYM1.
DR   HPA; ENSG00000197056; Low tissue specificity.
DR   neXtProt; NX_Q5SVZ6; -.
DR   OpenTargets; ENSG00000197056; -.
DR   PharmGKB; PA134948969; -.
DR   VEuPathDB; HostDB:ENSG00000197056; -.
DR   eggNOG; ENOG502QSU3; Eukaryota.
DR   GeneTree; ENSGT00940000157337; -.
DR   HOGENOM; CLU_012161_0_0_1; -.
DR   InParanoid; Q5SVZ6; -.
DR   OMA; IHMSGEM; -.
DR   OrthoDB; 537563at2759; -.
DR   PhylomeDB; Q5SVZ6; -.
DR   TreeFam; TF330114; -.
DR   PathwayCommons; Q5SVZ6; -.
DR   SignaLink; Q5SVZ6; -.
DR   BioGRID-ORCS; 79830; 17 hits in 1080 CRISPR screens.
DR   ChiTaRS; ZMYM1; human.
DR   GenomeRNAi; 79830; -.
DR   Pharos; Q5SVZ6; Tdark.
DR   PRO; PR:Q5SVZ6; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q5SVZ6; protein.
DR   Bgee; ENSG00000197056; Expressed in adrenal tissue and 152 other tissues.
DR   ExpressionAtlas; Q5SVZ6; baseline and differential.
DR   Genevisible; Q5SVZ6; HS.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR025398; DUF4371.
DR   InterPro; IPR008906; HATC_C_dom.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR011017; TRASH_dom.
DR   InterPro; IPR010507; Znf_MYM.
DR   Pfam; PF05699; Dimer_Tnp_hAT; 1.
DR   Pfam; PF14291; DUF4371; 1.
DR   Pfam; PF06467; zf-FCS; 2.
DR   SMART; SM00746; TRASH; 5.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   1: Evidence at protein level;
KW   Isopeptide bond; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Ubl conjugation; Zinc; Zinc-finger.
FT   CHAIN           1..1142
FT                   /note="Zinc finger MYM-type protein 1"
FT                   /id="PRO_0000191377"
FT   ZN_FING         110..148
FT                   /note="MYM-type 1"
FT   ZN_FING         160..203
FT                   /note="MYM-type 2"
FT   ZN_FING         210..245
FT                   /note="MYM-type 3"
FT   ZN_FING         300..331
FT                   /note="MYM-type 4"
FT   ZN_FING         452..538
FT                   /note="TTF-type"
FT   REGION          385..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CROSSLNK        25
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0007744|PubMed:25755297,
FT                   ECO:0007744|PubMed:28112733"
FT   CROSSLNK        284
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0007744|PubMed:28112733"
FT   VARIANT         73
FT                   /note="V -> M (in dbSNP:rs2971408)"
FT                   /evidence="ECO:0000269|PubMed:17974005, ECO:0000269|Ref.3"
FT                   /id="VAR_034589"
FT   VARIANT         454
FT                   /note="R -> Q (in dbSNP:rs7552714)"
FT                   /id="VAR_053767"
FT   VARIANT         493
FT                   /note="E -> G (in dbSNP:rs16837197)"
FT                   /id="VAR_053768"
SQ   SEQUENCE   1142 AA;  128717 MW;  C8F1197AB842C3E4 CRC64;
     MKEPLLGGEC DKAVASQLGL LDEIKTEPDN AQEYCHRQQS RTQENELKIN AVFSESASQL
     TAGIQLSLAS SGVNKMLPSV STTAIQVSCA GCKKILQKGQ TAYQRKGSAQ LFCSIPCITE
     YISSASSPVP SKRTCSNCSK DILNPKDVIS VQLEDTTSCK TFCSLSCLSS YEEKRKPFVT
     ICTNSILTKC SMCQKTAIIQ YEVKYQNVKH NLCSNACLSK FHSANNFIMN CCENCGTYCY
     TSSSLSHILQ MEGQSHYFNS SKSITAYKQK PAKPLISVPC KPLKPSDEMI ETTSDLGKTE
     LFCSINCFSA YSKAKMESSS VSVVSVVHDT STELLSPKKD TTPVISNIVS LADTDVALPI
     MNTDVLQDTV SSVTATADVI VDLSKSSPSE PSNAVASSST EQPSVSPSSS VFSQHAIGSS
     TEVQKDNMKS MKISDELCHP KCTSKVQKVK GKSRSIKKSC CADFECLENS KKDVAFCYSC
     QLFCQKYFSC GRESFATHGT SNWKKTLEKF RKHEKSEMHL KSLEFWREYQ FCDGAVSDDL
     SIHSKQIEGN KKYLKLIIEN ILFLGKQCLP LRGNDQSVSS VNKGNFLELL EMRAKDKGEE
     TFRLMNSQVD FYNSTQIQSD IIEIIKTEML QDIVNEINDS SAFSIICDET INSAMKEQLS
     ICVRYPQKSS KAILIKERFL GFVDTEEMTG THLHRTIKTY LQQIGVDMDK IHGQAYDSTT
     NLKIKFNKIA AEFKKEEPRA LYIHCYAHFL DLSIIRFCKE VKELRSALKT LSSLFNTICM
     SGEMLANFRN IYRLSQNKTC KKHISQSCWT VHDRTLLSVI DSLPEIIETL EVIASHSSNT
     SFADELSHLL TLVSKFEFVF CLKFLYRVLS VTGILSKELQ NKTIDIFSLS SKIEAILECL
     SSERNDVYFK TIWDGTEEIC QKITCKGFKV EKPSLQKRRK IQKSVDLGNS DNMFFPTSTE
     EQYKINIYYQ GLDTILQNLK LCFSEFDYCK IKQISELLFK WNEPLNETTA KHVQEFYKLD
     EDIIPELRFY RHYAKLNFVI DDSCINFVSL GCLFIQHGLH SNIPCLSKLL YIALSWPITS
     ASTENSFSTL PRLKTYLCNT MGQEKLTGPA LMAVEQELVN KLMEPERLNE IVEKFISQMK
     EI