ZMYM5_MACFA
ID ZMYM5_MACFA Reviewed; 666 AA.
AC Q4R3D6; G7PVU4;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-SEP-2015, sequence version 3.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=Zinc finger MYM-type protein 5;
GN Name=ZMYM5; ORFNames=QtsA-17725;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 11-666.
RC TISSUE=Testis;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a transcriptional regulator.
CC {ECO:0000250|UniProtKB:Q9UJ78}.
CC -!- SUBUNIT: Interacts (via N-terminal 120 amino acid region) with ETV5
CC (via C-terminal). {ECO:0000250|UniProtKB:Q9UJ78}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE02381.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; CM001292; EHH58467.1; -; Genomic_DNA.
DR EMBL; AB179330; BAE02381.1; ALT_INIT; mRNA.
DR RefSeq; NP_001306567.2; NM_001319638.2.
DR AlphaFoldDB; Q4R3D6; -.
DR SMR; Q4R3D6; -.
DR STRING; 9541.XP_005585511.1; -.
DR GeneID; 101867372; -.
DR KEGG; mcf:101867372; -.
DR CTD; 9205; -.
DR eggNOG; ENOG502S9U9; Eukaryota.
DR Proteomes; UP000009130; Chromosome 17.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR011017; TRASH_dom.
DR InterPro; IPR010507; Znf_MYM.
DR Pfam; PF06467; zf-FCS; 3.
DR SMART; SM00746; TRASH; 3.
PE 2: Evidence at transcript level;
KW Isopeptide bond; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..666
FT /note="Zinc finger MYM-type protein 5"
FT /id="PRO_0000343662"
FT ZN_FING 262..296
FT /note="MYM-type 1"
FT ZN_FING 308..348
FT /note="MYM-type 2"
FT ZN_FING 355..390
FT /note="MYM-type 3"
FT ZN_FING 401..428
FT /note="MYM-type 4"
FT REGION 87..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 85
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9UJ78"
FT CROSSLNK 88
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9UJ78"
FT CROSSLNK 146
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9UJ78"
FT CROSSLNK 163
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9UJ78"
FT CROSSLNK 222
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9UJ78"
FT CROSSLNK 440
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9UJ78"
FT CROSSLNK 452
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9UJ78"
FT CROSSLNK 459
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9UJ78"
FT CROSSLNK 549
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9UJ78"
FT CONFLICT 43
FT /note="V -> A (in Ref. 2; BAE02381)"
FT /evidence="ECO:0000305"
FT CONFLICT 284
FT /note="V -> A (in Ref. 2; BAE02381)"
FT /evidence="ECO:0000305"
FT CONFLICT 289
FT /note="F -> D (in Ref. 2; BAE02381)"
FT /evidence="ECO:0000305"
FT CONFLICT 402
FT /note="R -> T (in Ref. 2; BAE02381)"
FT /evidence="ECO:0000305"
FT CONFLICT 482
FT /note="N -> D (in Ref. 2; BAE02381)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 666 AA; 74318 MW; D24485D42B1272F7 CRC64;
MDKCSVGGLE LTEQTPALLG NMAMATSLMD IGDSFGHPAC PLVSRSRNSP VEDDDDVVFI
ESIQPPSVSA PAIADQRNFI LASSKNEKPQ GNYSVIPPPS RDLASQKGNI SETIVIDDEE
DIETNGGAEK NSSCFIEWGL PGTKNKTKDL DFSTSSLSRS KTKTGVRPFN PGRMNVAGDL
FQNGEFATHH SPDSWISQSA SFPRNQKQPG VDSLSPVALL RKQNFQPTAQ QQLTNPAKIT
CANCKKPLQK GQTAYQRKGS AHLFCCTTCL SSFSHKRTQN TRSVICKKFA STKKADVVLP
VESSRSFQEF CSTSCVSPCE NNRNLKKGVF NKSRCTICSK LAEIRHEVSV NNVTHKLCSN
HCFNKYRLAN GLIMNCCEHC GEYMPSKSTG NNILVIGGQQ KRFCCQSCIN EYKQMMETKS
KKLTASENRK RNAVREENEK QFCGLSSTLL KKIDGITEKK EKTSELHLSV ECGTDTLLIK
ENVNLPPSSA SAIADTFQEQ LEEKNFEDSI VPVVLSADPG TWPRILNIKQ RDTLVENVPP
QVRNFNFPKD NTGRKFSETY YTRILPNGEK TTRSWLLYST SKDSVFCLYC RLFGEGKNQL
KNENGCKDWQ HLSHILSKHE ESEMHINNSV KYSKLKSDLK KNKAIDAAER RLYENEKNDG
ALLLYT
