ZMYM5_MOUSE
ID ZMYM5_MOUSE Reviewed; 627 AA.
AC Q3U2E2; Q8R1W3;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Zinc finger MYM-type protein 5;
GN Name=Zmym5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-425.
RC STRAIN=NOD;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 277-627.
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Functions as a transcriptional regulator.
CC {ECO:0000250|UniProtKB:Q9UJ78}.
CC -!- SUBUNIT: Interacts (via N-terminal 120 amino acid region) with ETV5
CC (via C-terminal). {ECO:0000250|UniProtKB:Q9UJ78}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BC023007; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};
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DR EMBL; AC154361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK155333; BAE33199.1; -; mRNA.
DR EMBL; BC023007; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS49505.1; -.
DR RefSeq; NP_001240681.1; NM_001253752.1.
DR RefSeq; NP_001240682.1; NM_001253753.1.
DR RefSeq; NP_659091.3; NM_144842.4.
DR RefSeq; XP_006518916.1; XM_006518853.1.
DR RefSeq; XP_006518917.1; XM_006518854.1.
DR RefSeq; XP_006518918.1; XM_006518855.1.
DR RefSeq; XP_006518920.1; XM_006518857.1.
DR RefSeq; XP_011243324.1; XM_011245022.2.
DR RefSeq; XP_017171456.1; XM_017315967.1.
DR RefSeq; XP_017171457.1; XM_017315968.1.
DR RefSeq; XP_017171458.1; XM_017315969.1.
DR AlphaFoldDB; Q3U2E2; -.
DR SMR; Q3U2E2; -.
DR BioGRID; 230109; 1.
DR IntAct; Q3U2E2; 1.
DR STRING; 10090.ENSMUSP00000134057; -.
DR iPTMnet; Q3U2E2; -.
DR PhosphoSitePlus; Q3U2E2; -.
DR EPD; Q3U2E2; -.
DR jPOST; Q3U2E2; -.
DR MaxQB; Q3U2E2; -.
DR PaxDb; Q3U2E2; -.
DR PeptideAtlas; Q3U2E2; -.
DR PRIDE; Q3U2E2; -.
DR ProteomicsDB; 299569; -.
DR Antibodypedia; 22270; 37 antibodies from 13 providers.
DR DNASU; 219105; -.
DR Ensembl; ENSMUST00000039812; ENSMUSP00000043625; ENSMUSG00000040123.
DR Ensembl; ENSMUST00000111285; ENSMUSP00000106916; ENSMUSG00000040123.
DR Ensembl; ENSMUST00000173954; ENSMUSP00000134057; ENSMUSG00000040123.
DR GeneID; 219105; -.
DR KEGG; mmu:219105; -.
DR UCSC; uc007ucl.2; mouse.
DR CTD; 9205; -.
DR MGI; MGI:3041170; Zmym5.
DR VEuPathDB; HostDB:ENSMUSG00000040123; -.
DR eggNOG; ENOG502S9U9; Eukaryota.
DR GeneTree; ENSGT00940000162379; -.
DR HOGENOM; CLU_026638_1_0_1; -.
DR InParanoid; Q3U2E2; -.
DR OMA; EHCGEYM; -.
DR PhylomeDB; Q3U2E2; -.
DR BioGRID-ORCS; 219105; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Zmym5; mouse.
DR PRO; PR:Q3U2E2; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q3U2E2; protein.
DR Bgee; ENSMUSG00000040123; Expressed in rostral migratory stream and 252 other tissues.
DR ExpressionAtlas; Q3U2E2; baseline and differential.
DR Genevisible; Q3U2E2; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR InterPro; IPR011017; TRASH_dom.
DR InterPro; IPR010507; Znf_MYM.
DR Pfam; PF06467; zf-FCS; 2.
DR SMART; SM00746; TRASH; 3.
PE 2: Evidence at transcript level;
KW Isopeptide bond; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..627
FT /note="Zinc finger MYM-type protein 5"
FT /id="PRO_0000343663"
FT ZN_FING 234..268
FT /note="MYM-type 1"
FT ZN_FING 280..319
FT /note="MYM-type 2; degenerate"
FT ZN_FING 326..354
FT /note="MYM-type 4"
FT ZN_FING 370..396
FT /note="MYM-type 5"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 91..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 59
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9UJ78"
FT CROSSLNK 137
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9UJ78"
FT CROSSLNK 195
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9UJ78"
FT CROSSLNK 408
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9UJ78"
FT CROSSLNK 427
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9UJ78"
FT CROSSLNK 517
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9UJ78"
SQ SEQUENCE 627 AA; 70071 MW; 50F8712583563BE9 CRC64;
MEAHLADMES SGGPTSSLAG TSRNTHVEDD DVVFIESVQP PICAPAIPNE RNFVFASSKH
ENPPGTDSTI SPSWRDLTSQ KGNLCETIVI DDEGDTDTNG GEEKNPTDFI EWGPNGNKSS
TKNVDFPIAS LSRSKTKTAV GPFNPGRIDV TDAFQNGRFA VHHNPDSWIS QSASFPRNQK
QQGVDSLSPV ASLPKQIFQP SNQQPTKPVK VTCANCKKPL QKGQTAYQRK GSAHLFCSTT
CLSSFSHKRT RKTRNVMCKK DSPVRTTTIV PPVESSKSLQ GFYNASLSPY ENCQSLRKEV
FTKSRCIICN KLGEVRHEIS VNSITHKLCS NNCFNEYRLT NGLIMNCCEQ CSKYMPKSTG
HSILITGQQK RFCCQNCADE YKEIMEAKSK LLLLQNRKRN AIREENEKRL RESSGTLSGN
TGDIPEKKEK SSEIIKVAAD CSLDTSSEEQ NVNLPCSVAV ISDTFKEQLG DKNSEELDMS
ILPSLDPGSW PRILNMKQRE FLVKNNPPQI RNFNFPKDSA GKKFSETYYT RILPNGEKGT
RPWLLYSASK DSVFCLYCRL FGEGKNQLRN ENGCKDWHHL SHLLSKHDES EMHINNSVKY
SKLKSDLENK TNEATEGGED CVQLLYT
