ZMYM6_HUMAN
ID ZMYM6_HUMAN Reviewed; 1325 AA.
AC O95789; B4DRJ6; Q32Q23; Q4G108; Q5SVZ9; Q5SW00; Q69YL4; Q96IY0; Q9NWF1;
AC Q9P2J4;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Zinc finger MYM-type protein 6;
DE AltName: Full=Transposon-derived Buster2 transposase-like protein;
DE AltName: Full=Zinc finger protein 258;
GN Name=ZMYM6; Synonyms=Buster2, KIAA1353, ZNF258;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=10486218; DOI=10.1006/geno.1999.5918;
RA Smedley D., Hamoudi R., Lu Y.-J., Cooper C., Shipley J.;
RT "Cloning and mapping of members of the MYM family.";
RL Genomics 60:244-247(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
RC TISSUE=Brain;
RX PubMed=10718198; DOI=10.1093/dnares/7.1.65;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVI. The
RT complete sequences of 150 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:65-73(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Melanoma;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-970 (ISOFORM 3).
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP FUNCTION.
RX PubMed=21834987; DOI=10.1186/1741-7007-9-54;
RA Bai S.W., Herrera-Abreu M.T., Rohn J.L., Racine V., Tajadura V.,
RA Suryavanshi N., Bechtel S., Wiemann S., Baum B., Ridley A.J.;
RT "Identification and characterization of a set of conserved and new
RT regulators of cytoskeletal organisation, cell morphology and migration.";
RL BMC Biol. 9:54-54(2011).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-397, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Plays a role in the regulation of cell morphology and
CC cytoskeletal organization. {ECO:0000269|PubMed:21834987}.
CC -!- INTERACTION:
CC O95789-4; P54253: ATXN1; NbExp=6; IntAct=EBI-12949277, EBI-930964;
CC O95789-4; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-12949277, EBI-11524452;
CC O95789-4; Q8NDZ0: BEND2; NbExp=3; IntAct=EBI-12949277, EBI-954079;
CC O95789-4; P49711: CTCF; NbExp=3; IntAct=EBI-12949277, EBI-932887;
CC O95789-4; P21333-2: FLNA; NbExp=3; IntAct=EBI-12949277, EBI-9641086;
CC O95789-4; P42858: HTT; NbExp=3; IntAct=EBI-12949277, EBI-466029;
CC O95789-4; P31153: MAT2A; NbExp=3; IntAct=EBI-12949277, EBI-1050743;
CC O95789-4; Q13952-2: NFYC; NbExp=3; IntAct=EBI-12949277, EBI-11956831;
CC O95789-4; Q16656-4: NRF1; NbExp=3; IntAct=EBI-12949277, EBI-11742836;
CC O95789-4; Q8N2W9: PIAS4; NbExp=3; IntAct=EBI-12949277, EBI-473160;
CC O95789-4; D3DTS7: PMP22; NbExp=3; IntAct=EBI-12949277, EBI-25882629;
CC O95789-4; P14859-6: POU2F1; NbExp=3; IntAct=EBI-12949277, EBI-11526590;
CC O95789-4; P00441: SOD1; NbExp=3; IntAct=EBI-12949277, EBI-990792;
CC O95789-4; P17752: TPH1; NbExp=3; IntAct=EBI-12949277, EBI-3956833;
CC O95789-4; O43167: ZBTB24; NbExp=3; IntAct=EBI-12949277, EBI-744471;
CC O95789-4; P36508: ZNF76; NbExp=3; IntAct=EBI-12949277, EBI-7254550;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=3;
CC IsoId=O95789-3; Sequence=Displayed;
CC Name=2;
CC IsoId=O95789-2; Sequence=VSP_011446, VSP_011447;
CC Name=1;
CC IsoId=O95789-1; Sequence=VSP_034682, VSP_034683;
CC Name=4;
CC IsoId=O95789-4; Sequence=VSP_034680, VSP_034681;
CC Name=5;
CC IsoId=O95789-5; Sequence=VSP_035287, VSP_035288;
CC -!- TISSUE SPECIFICITY: Expressed at high levels in heart, skeletal muscle,
CC kidney and liver. {ECO:0000269|PubMed:10486218}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH33903.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=AAI07881.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=BAA92591.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF055470; AAD15797.1; -; mRNA.
DR EMBL; AB037774; BAA92591.1; ALT_INIT; mRNA.
DR EMBL; AK299293; BAG61308.1; -; mRNA.
DR EMBL; BT007117; AAP35781.1; -; mRNA.
DR EMBL; AL832911; CAH10638.1; -; mRNA.
DR EMBL; AC114490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL607089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC033903; AAH33903.1; ALT_SEQ; mRNA.
DR EMBL; BC068534; AAH68534.1; -; mRNA.
DR EMBL; BC107880; AAI07881.1; ALT_SEQ; mRNA.
DR EMBL; BC117463; AAI17464.1; -; mRNA.
DR CCDS; CCDS387.2; -. [O95789-3]
DR RefSeq; NP_009098.3; NM_007167.3. [O95789-3]
DR AlphaFoldDB; O95789; -.
DR BioGRID; 114638; 81.
DR IntAct; O95789; 48.
DR STRING; 9606.ENSP00000349708; -.
DR GlyGen; O95789; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; O95789; -.
DR PhosphoSitePlus; O95789; -.
DR BioMuta; ZMYM6; -.
DR EPD; O95789; -.
DR jPOST; O95789; -.
DR MassIVE; O95789; -.
DR MaxQB; O95789; -.
DR PaxDb; O95789; -.
DR PeptideAtlas; O95789; -.
DR PRIDE; O95789; -.
DR ProteomicsDB; 51049; -. [O95789-3]
DR ProteomicsDB; 51050; -. [O95789-1]
DR ProteomicsDB; 51051; -. [O95789-2]
DR ProteomicsDB; 51052; -. [O95789-4]
DR ProteomicsDB; 51053; -. [O95789-5]
DR Antibodypedia; 2613; 96 antibodies from 17 providers.
DR DNASU; 9204; -.
DR Ensembl; ENST00000317538.9; ENSP00000326695.5; ENSG00000163867.17. [O95789-4]
DR Ensembl; ENST00000357182.9; ENSP00000349708.4; ENSG00000163867.17. [O95789-3]
DR Ensembl; ENST00000373333.1; ENSP00000362430.1; ENSG00000163867.17. [O95789-4]
DR GeneID; 9204; -.
DR KEGG; hsa:9204; -.
DR MANE-Select; ENST00000357182.9; ENSP00000349708.4; NM_007167.4; NP_009098.3.
DR UCSC; uc001byh.4; human. [O95789-3]
DR CTD; 9204; -.
DR DisGeNET; 9204; -.
DR GeneCards; ZMYM6; -.
DR HGNC; HGNC:13050; ZMYM6.
DR HPA; ENSG00000163867; Low tissue specificity.
DR MIM; 613567; gene.
DR neXtProt; NX_O95789; -.
DR OpenTargets; ENSG00000163867; -.
DR PharmGKB; PA37628; -.
DR VEuPathDB; HostDB:ENSG00000163867; -.
DR eggNOG; ENOG502QT83; Eukaryota.
DR GeneTree; ENSGT00940000159550; -.
DR GeneTree; ENSGT00940000162386; -.
DR HOGENOM; CLU_265906_0_0_1; -.
DR InParanoid; O95789; -.
DR OMA; CEGRANM; -.
DR OrthoDB; 587724at2759; -.
DR PhylomeDB; O95789; -.
DR TreeFam; TF336988; -.
DR PathwayCommons; O95789; -.
DR SignaLink; O95789; -.
DR BioGRID-ORCS; 9204; 8 hits in 1053 CRISPR screens.
DR ChiTaRS; ZMYM6; human.
DR GenomeRNAi; 9204; -.
DR Pharos; O95789; Tdark.
DR PRO; PR:O95789; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; O95789; protein.
DR Bgee; ENSG00000163867; Expressed in monocyte and 152 other tissues.
DR ExpressionAtlas; O95789; baseline and differential.
DR Genevisible; O95789; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; TAS:ProtInc.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0007010; P:cytoskeleton organization; IMP:UniProtKB.
DR GO; GO:0022604; P:regulation of cell morphogenesis; IMP:UniProtKB.
DR InterPro; IPR025398; DUF4371.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR011017; TRASH_dom.
DR InterPro; IPR010507; Znf_MYM.
DR Pfam; PF14291; DUF4371; 1.
DR Pfam; PF06467; zf-FCS; 3.
DR SMART; SM00746; TRASH; 9.
DR SUPFAM; SSF53098; SSF53098; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..1325
FT /note="Zinc finger MYM-type protein 6"
FT /id="PRO_0000191381"
FT ZN_FING 113..151
FT /note="MYM-type 1"
FT ZN_FING 163..206
FT /note="MYM-type 2"
FT ZN_FING 213..248
FT /note="MYM-type 3"
FT ZN_FING 296..334
FT /note="MYM-type 4"
FT ZN_FING 342..443
FT /note="MYM-type 5"
FT ZN_FING 451..485
FT /note="MYM-type 6"
FT ZN_FING 492..531
FT /note="MYM-type 7"
FT ZN_FING 538..572
FT /note="MYM-type 8"
FT REGION 665..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..704
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 397
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..687
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:10718198"
FT /id="VSP_035287"
FT VAR_SEQ 144..170
FT /note="DILNPKDVITTRFENSYPSKDFCSQSC -> YKILNIPFYFTFFLVCILFSS
FT NILLIL (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_034680"
FT VAR_SEQ 144..156
FT /note="DILNPKDVITTRF -> YKILNIPFYFTFF (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_011446"
FT VAR_SEQ 157..1325
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_011447"
FT VAR_SEQ 171..1325
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_034681"
FT VAR_SEQ 688..715
FT /note="NKGISCKPVTQTKATSCKPHTQHKECQT -> MNFKYVGRYIKNIAYLFLKI
FT TVIQIFHS (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:10718198"
FT /id="VSP_035288"
FT VAR_SEQ 716..723
FT /note="DLPMPNEK -> ECPVRAVC (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:10486218"
FT /id="VSP_034682"
FT VAR_SEQ 724..1325
FT /note="Missing (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:10486218"
FT /id="VSP_034683"
FT VARIANT 660
FT /note="K -> R (in dbSNP:rs10158256)"
FT /id="VAR_044432"
FT VARIANT 1233
FT /note="E -> K (in dbSNP:rs16837147)"
FT /id="VAR_044433"
FT CONFLICT 44
FT /note="S -> G (in Ref. 7; AAI07881)"
FT /evidence="ECO:0000305"
FT CONFLICT 413
FT /note="A -> G (in Ref. 1; AAD15797)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1325 AA; 148089 MW; 1BC8ADE286A27F5A CRC64;
MKEPLDGECG KAVVPQQELL DKIKEEPDNA QEYGCVQQPK TQESKLKIGG VSSVNERPIA
QQLNPGFQLS FASSGPSVLL PSVPAVAIKV FCSGCKKMLY KGQTAYHKTG STQLFCSTRC
ITRHSSPACL PPPPKKTCTN CSKDILNPKD VITTRFENSY PSKDFCSQSC LSSYELKKKP
VVTIYTKSIS TKCSMCQKNA DTRFEVKYQN VVHGLCSDAC FSKFHSTNNL TMNCCENCGS
YCYSSSGPCQ SQKVFSSTSV TAYKQNSAQI PPYALGKSLR PSAEMIETTN DSGKTELFCS
INCLSAYRVK TVTSSGVQVS CHSCKTSAIP QYHLAMSNGT IYSFCSSSCV VAFQNVFSKP
KGTNSSAVPL SQGQVVVSPP SSRSAVSIGG GNTSAVSPSS IRGSAAASLQ PLAEQSQQVA
LTHTVVKLKC QHCNHLFATK PELLFYKGKM FLFCGKNCSD EYKKKNKVVA MCDYCKLQKI
IKETVRFSGV DKPFCSEVCK FLSARDFGER WGNYCKMCSY CSQTSPNLVE NRLEGKLEEF
CCEDCMSKFT VLFYQMAKCD GCKRQGKLSE SIKWRGNIKH FCNLFCVLEF CHQQIMNDCL
PQNKVNISKA KTAVTELPSA RTDTTPVITS VMSLAKIPAT LSTGNTNSVL KGAVTKEAAK
IIQDESTQED AMKFPSSQSS QPSRLLKNKG ISCKPVTQTK ATSCKPHTQH KECQTDLPMP
NEKNDAELDS PPSKKKRLGF FQTYDTEYLK VGFIICPGSK ESSPRPQCVI CGEILSSENM
KPANLSHHLK TKHSELENKP VDFFEQKSLE MECQNSSLKK CLLVEKSLVK ASYLIAFQTA
ASKKPFSIAE ELIKPYLVEM CSEVLGSSAG DKMKTIPLSN VTIQHRIDEL SADIEDQLIQ
KVRESKWFAL QIDESSEISN ITLLLCYIRF IDYDCRDVKE ELLFCIEMPT QITGFEIFEL
INKYIDSKSL NWKHCVGLCT DGAASMTGRY SGLKAKIQEV AMNTAAFTHC FIHRERLVAE
KLSPCLHKIL LQSAQILSFI KSNALNSRML TILCEEMGSE HVSLPLHAEV RWISRGRMLK
RLFELRHEIE IFLSQKHSDL AKYFHDEEWV GKLAYLSDIF SLINELNLSL QGTLTTFFNL
CNKIDVFKRK LKMWLKRTQE NDYDMFPSFS EFSNSSGLNM TDITRIIFEH LEGLSQVFSD
CFPPEQDLRS GNLWIIHPFM NHQNNNLTDF EEEKLTELSS DLGLQALFKS VSVTQFWINA
KTSYPELHER AMKFLLPFST VYLCDAAFSA LTESKQKNLL GSGPALRLAV TSLIPRIEKL
VKEKE
