ZN100_HUMAN
ID ZN100_HUMAN Reviewed; 542 AA.
AC Q8IYN0; Q7M4M0;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Zinc finger protein 100;
GN Name=ZNF100;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-389.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 381-437, AND VARIANT ILE-389.
RX PubMed=1740334; DOI=10.1016/0888-7543(92)90372-y;
RA Hoovers J.M.N., Mannens M., John R., Bliek J., van Heyningen V.,
RA Porteous D.J., Leschot N.J., Westerveld A., Little P.F.R.;
RT "High-resolution localization of 69 potential human zinc finger protein
RT genes: a number are clustered.";
RL Genomics 12:254-263(1992).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8IYN0; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-2849363, EBI-10176379;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AC092364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC035579; AAH35579.1; -; mRNA.
DR CCDS; CCDS42538.1; -.
DR PIR; E42075; E42075.
DR RefSeq; NP_775802.2; NM_173531.3.
DR AlphaFoldDB; Q8IYN0; -.
DR SMR; Q8IYN0; -.
DR BioGRID; 127858; 19.
DR IntAct; Q8IYN0; 12.
DR STRING; 9606.ENSP00000351042; -.
DR iPTMnet; Q8IYN0; -.
DR PhosphoSitePlus; Q8IYN0; -.
DR BioMuta; ZNF100; -.
DR DMDM; 296453037; -.
DR EPD; Q8IYN0; -.
DR jPOST; Q8IYN0; -.
DR MassIVE; Q8IYN0; -.
DR MaxQB; Q8IYN0; -.
DR PaxDb; Q8IYN0; -.
DR PeptideAtlas; Q8IYN0; -.
DR PRIDE; Q8IYN0; -.
DR ProteomicsDB; 71207; -.
DR Antibodypedia; 28703; 33 antibodies from 14 providers.
DR DNASU; 163227; -.
DR Ensembl; ENST00000358296.11; ENSP00000351042.5; ENSG00000197020.12.
DR Ensembl; ENST00000614218.4; ENSP00000483779.1; ENSG00000274746.4.
DR GeneID; 163227; -.
DR KEGG; hsa:163227; -.
DR MANE-Select; ENST00000358296.11; ENSP00000351042.5; NM_173531.4; NP_775802.2.
DR UCSC; uc002nqi.4; human.
DR CTD; 163227; -.
DR DisGeNET; 163227; -.
DR GeneCards; ZNF100; -.
DR HGNC; HGNC:12880; ZNF100.
DR HPA; ENSG00000197020; Low tissue specificity.
DR MIM; 603982; gene.
DR neXtProt; NX_Q8IYN0; -.
DR OpenTargets; ENSG00000197020; -.
DR PharmGKB; PA37469; -.
DR VEuPathDB; HostDB:ENSG00000197020; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT01050000244908; -.
DR InParanoid; Q8IYN0; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8IYN0; -.
DR TreeFam; TF342117; -.
DR PathwayCommons; Q8IYN0; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8IYN0; -.
DR BioGRID-ORCS; 163227; 19 hits in 1064 CRISPR screens.
DR ChiTaRS; ZNF100; human.
DR GenomeRNAi; 163227; -.
DR Pharos; Q8IYN0; Tdark.
DR PRO; PR:Q8IYN0; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8IYN0; protein.
DR Bgee; ENSG00000197020; Expressed in corpus callosum and 103 other tissues.
DR ExpressionAtlas; Q8IYN0; baseline and differential.
DR Genevisible; Q8IYN0; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 10.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..542
FT /note="Zinc finger protein 100"
FT /id="PRO_0000047405"
FT DOMAIN 35..107
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 177..199
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 205..227
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 233..255
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 261..283
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 289..311
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 317..339
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 345..367
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 373..395
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 401..423
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 429..451
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 457..479
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 485..507
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 8
FT /note="M -> V (in dbSNP:rs12974842)"
FT /id="VAR_057395"
FT VARIANT 389
FT /note="T -> I (in dbSNP:rs7246400)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:1740334"
FT /id="VAR_060422"
FT CONFLICT 411..412
FT /note="NW -> WN (in Ref. 3; no nucleotide entry)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 542 AA; 62745 MW; 9755C6215FC44C87 CRC64;
MDDPRYGMCP LKGASGCPGA ERSLLVQSYF EKGPLTFRDV AIEFSLEEWQ CLDSAQQGLY
RKVMLENYRN LVFLAGIALT KPDLITCLEQ GKEPWNIKRH EMVAKPPVIC SHFPQDLWAE
QDIKDSFQEA ILKKYGKYGH DNLQLQKGCK SVDECKVHKE HDNKLNQCLI TTQSNIFQCD
PSAKVFHTFS NSNRHKIRHT RKKPFKCKKC EKSFCMLLHL TQHKRFHITE NSYQCKDCGK
AFNWFSTLTT HRRIHTGEKP YKCEECGKAF NRSSHLTTHK IIHTGEKPYR CEECGKAFNR
SSHLTTHKRI HTGVKPYKCT ECGKAFNRSS HLTTHRIIHT GEKPYKCEEC GKAFNQSSTL
TTHKITHAGE KPYKCEECGK AFYRFSYLTK HKTSHTGEKF YKCEECGKGF NWSSALTKHK
RIHTGEKPYK CEECGKAFNE SSNLTTHKMI HTGEKPYKCD ECGKAFNRSS QLTAHKMIHT
GEKPYKCEEC GKAFNRSSTL TKHKITHTGE KSYKWEECGK DFNQSLSLIK QNNSYWRETL
QM
