ZN101_HUMAN
ID ZN101_HUMAN Reviewed; 436 AA.
AC Q8IZC7; C9JU83; Q0VDG9;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Zinc finger protein 101;
DE AltName: Full=Zinc finger protein HZF12;
GN Name=ZNF101;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=14727140; DOI=10.1007/s00335-003-3022-0;
RA Looman C., Hellman L., Abrink M.;
RT "A novel Kruppel-associated box identified in a panel of mammalian zinc
RT finger proteins.";
RL Mamm. Genome 15:35-40(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8IZC7; Q6A162: KRT40; NbExp=3; IntAct=EBI-5278328, EBI-10171697;
CC Q8IZC7; P60409: KRTAP10-7; NbExp=6; IntAct=EBI-5278328, EBI-10172290;
CC Q8IZC7; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-5278328, EBI-10171774;
CC Q8IZC7; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-5278328, EBI-11953334;
CC Q8IZC7; Q9BYP8: KRTAP17-1; NbExp=3; IntAct=EBI-5278328, EBI-11988175;
CC Q8IZC7; Q99750: MDFI; NbExp=6; IntAct=EBI-5278328, EBI-724076;
CC Q8IZC7; P17020: ZNF16; NbExp=3; IntAct=EBI-5278328, EBI-3921553;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8IZC7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IZC7-2; Sequence=VSP_055937;
CC -!- TISSUE SPECIFICITY: Expressed in a variety of adult and fetal tissues.
CC {ECO:0000269|PubMed:14727140}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AY149174; AAN46749.1; -; mRNA.
DR EMBL; AC011458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC119680; AAI19681.1; -; mRNA.
DR CCDS; CCDS32971.1; -. [Q8IZC7-1]
DR CCDS; CCDS77271.1; -. [Q8IZC7-2]
DR RefSeq; NP_001287878.1; NM_001300949.1. [Q8IZC7-2]
DR RefSeq; NP_149981.2; NM_033204.3. [Q8IZC7-1]
DR AlphaFoldDB; Q8IZC7; -.
DR SMR; Q8IZC7; -.
DR BioGRID; 125102; 34.
DR IntAct; Q8IZC7; 15.
DR STRING; 9606.ENSP00000468049; -.
DR iPTMnet; Q8IZC7; -.
DR PhosphoSitePlus; Q8IZC7; -.
DR BioMuta; ZNF101; -.
DR DMDM; 55976740; -.
DR EPD; Q8IZC7; -.
DR jPOST; Q8IZC7; -.
DR MassIVE; Q8IZC7; -.
DR MaxQB; Q8IZC7; -.
DR PaxDb; Q8IZC7; -.
DR PeptideAtlas; Q8IZC7; -.
DR PRIDE; Q8IZC7; -.
DR ProteomicsDB; 58828; -.
DR ProteomicsDB; 71319; -. [Q8IZC7-1]
DR Antibodypedia; 28552; 111 antibodies from 20 providers.
DR DNASU; 94039; -.
DR Ensembl; ENST00000318110.9; ENSP00000319716.5; ENSG00000181896.12. [Q8IZC7-1]
DR Ensembl; ENST00000415784.6; ENSP00000400952.2; ENSG00000181896.12. [Q8IZC7-2]
DR Ensembl; ENST00000592502.2; ENSP00000468049.1; ENSG00000181896.12. [Q8IZC7-1]
DR GeneID; 94039; -.
DR KEGG; hsa:94039; -.
DR MANE-Select; ENST00000592502.2; ENSP00000468049.1; NM_033204.4; NP_149981.2.
DR UCSC; uc002nni.3; human. [Q8IZC7-1]
DR CTD; 94039; -.
DR DisGeNET; 94039; -.
DR GeneCards; ZNF101; -.
DR HGNC; HGNC:12881; ZNF101.
DR HPA; ENSG00000181896; Tissue enhanced (lymphoid).
DR MIM; 603983; gene.
DR neXtProt; NX_Q8IZC7; -.
DR OpenTargets; ENSG00000181896; -.
DR PharmGKB; PA37470; -.
DR VEuPathDB; HostDB:ENSG00000181896; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00950000182755; -.
DR HOGENOM; CLU_002678_0_10_1; -.
DR InParanoid; Q8IZC7; -.
DR OMA; RAHAGHT; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8IZC7; -.
DR PathwayCommons; Q8IZC7; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8IZC7; -.
DR BioGRID-ORCS; 94039; 9 hits in 1100 CRISPR screens.
DR GenomeRNAi; 94039; -.
DR Pharos; Q8IZC7; Tdark.
DR PRO; PR:Q8IZC7; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8IZC7; protein.
DR Bgee; ENSG00000181896; Expressed in buccal mucosa cell and 154 other tissues.
DR ExpressionAtlas; Q8IZC7; baseline and differential.
DR Genevisible; Q8IZC7; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..436
FT /note="Zinc finger protein 101"
FT /id="PRO_0000047406"
FT DOMAIN 4..82
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 102..124
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 169..191
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 197..219
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 225..247
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 253..276
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 282..304
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 310..332
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 338..360
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 366..388
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 394..416
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 128..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..145
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..120
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_055937"
FT VARIANT 121
FT /note="M -> L (in dbSNP:rs4808209)"
FT /id="VAR_024197"
SQ SEQUENCE 436 AA; 50339 MW; 48EEA2EEA86212B3 CRC64;
MDSVAFEDVA VNFTQEEWAL LSPSQKNLYR DVTLETFRNL ASVGIQWKDQ DIENLYQNLG
IKLRSLVERL CGRKEGNEHR ETFSQIPDCH LNKKSQTGVK PCKCSVCGKV FLRHSFLDRH
MRAHAGHKRS ECGGEWRETP RKQKQHGKAS ISPSSGARRT VTPTRKRPYE CKVCGKAFNS
PNLFQIHQRT HTGKRSYKCR EIVRAFTVSS FFRKHGKMHT GEKRYECKYC GKPIDYPSLF
QIHVRTHTGE KPYKCKQCGK AFISAGYLRT HEIRSHALEK SHQCQECGKK LSCSSSLHRH
ERTHSGGKLY ECQKCAKVFR CPTSLQAHER AHTGERPYEC NKCGKTFNYP SCFRRHKKTH
SGEKPYECTR CGKAFGWCSS LRRHEMTHTG EKPFDCKQCG KVFTFSNYLR LHERTHLAGR
SQCFGRRQGD HLSPGV
