ZN112_HUMAN
ID ZN112_HUMAN Reviewed; 913 AA.
AC Q9UJU3; A4FU53; Q9HCA7;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 183.
DE RecName: Full=Zinc finger protein 112;
DE Short=Zfp-112;
DE AltName: Full=Zinc finger protein 228;
GN Name=ZNF112; Synonyms=ZFP112, ZNF228;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS GLN-446 AND HIS-485.
RX PubMed=12743021; DOI=10.1101/gr.963903;
RA Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.;
RT "Differential expansion of zinc-finger transcription factor loci in
RT homologous human and mouse gene clusters.";
RL Genome Res. 13:1097-1110(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING (ISOFORM 1).
RA Kodoyianni V., Ge Y., Krummel G.K., Kvikstad E., Grable L., Severin J.,
RA Gordon L., Shannon M., Brower A., Olsen A.S., Smith L.M.;
RT "Sequence analysis of a 1Mb region in 19q13.2 containing a zinc finger gene
RT cluster.";
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS LEU-159;
RP GLN-446 AND HIS-485.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANTS LEU-159;
RP GLN-446 AND HIS-485.
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-256 AND LYS-890, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9UJU3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UJU3-2; Sequence=VSP_039929;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AF198358; AAF12816.1; -; mRNA.
DR EMBL; AC084239; AAG23968.1; -; Genomic_DNA.
DR EMBL; AC138473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471126; EAW57269.1; -; Genomic_DNA.
DR EMBL; BC101753; AAI01754.1; -; mRNA.
DR CCDS; CCDS12637.1; -. [Q9UJU3-2]
DR CCDS; CCDS54276.1; -. [Q9UJU3-1]
DR RefSeq; NP_001076804.1; NM_001083335.1. [Q9UJU3-1]
DR RefSeq; NP_001335211.1; NM_001348282.1. [Q9UJU3-2]
DR RefSeq; NP_001335212.1; NM_001348283.1. [Q9UJU3-2]
DR AlphaFoldDB; Q9UJU3; -.
DR SMR; Q9UJU3; -.
DR BioGRID; 113554; 7.
DR IntAct; Q9UJU3; 2.
DR STRING; 9606.ENSP00000337081; -.
DR iPTMnet; Q9UJU3; -.
DR PhosphoSitePlus; Q9UJU3; -.
DR BioMuta; ZNF112; -.
DR DMDM; 311033503; -.
DR jPOST; Q9UJU3; -.
DR MassIVE; Q9UJU3; -.
DR PaxDb; Q9UJU3; -.
DR PeptideAtlas; Q9UJU3; -.
DR PRIDE; Q9UJU3; -.
DR ProteomicsDB; 84657; -. [Q9UJU3-2]
DR Antibodypedia; 17710; 63 antibodies from 18 providers.
DR DNASU; 7771; -.
DR Ensembl; ENST00000337401.8; ENSP00000337081.3; ENSG00000062370.17. [Q9UJU3-1]
DR Ensembl; ENST00000354340.9; ENSP00000346305.3; ENSG00000062370.17. [Q9UJU3-2]
DR GeneID; 7771; -.
DR KEGG; hsa:7771; -.
DR MANE-Select; ENST00000354340.9; ENSP00000346305.3; NM_013380.4; NP_037512.3. [Q9UJU3-2]
DR UCSC; uc002ozc.5; human. [Q9UJU3-1]
DR CTD; 7771; -.
DR GeneCards; ZNF112; -.
DR HGNC; HGNC:12892; ZNF112.
DR HPA; ENSG00000062370; Low tissue specificity.
DR neXtProt; NX_Q9UJU3; -.
DR OpenTargets; ENSG00000062370; -.
DR VEuPathDB; HostDB:ENSG00000062370; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162215; -.
DR HOGENOM; CLU_002678_31_0_1; -.
DR InParanoid; Q9UJU3; -.
DR OMA; LCQVWAG; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9UJU3; -.
DR PathwayCommons; Q9UJU3; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9UJU3; -.
DR BioGRID-ORCS; 7771; 11 hits in 1073 CRISPR screens.
DR ChiTaRS; ZNF112; human.
DR GenomeRNAi; 7771; -.
DR Pharos; Q9UJU3; Tdark.
DR PRO; PR:Q9UJU3; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9UJU3; protein.
DR Bgee; ENSG00000062370; Expressed in germinal epithelium of ovary and 169 other tissues.
DR ExpressionAtlas; Q9UJU3; baseline and differential.
DR Genevisible; Q9UJU3; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 11.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 17.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..913
FT /note="Zinc finger protein 112"
FT /id="PRO_0000047469"
FT DOMAIN 8..79
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 258..280
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 443..465
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 471..493
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 497..519
FT /note="C2H2-type 4; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 525..547
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 553..575
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 581..603
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 609..631
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 637..659
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 665..687
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 693..715
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 721..743
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 749..771
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 777..799
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 805..827
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 833..855
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 861..883
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CROSSLNK 256
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 890
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 1..6
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_039929"
FT VARIANT 54
FT /note="P -> S (in dbSNP:rs11673395)"
FT /id="VAR_060414"
FT VARIANT 159
FT /note="F -> L (in dbSNP:rs4280359)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.4"
FT /id="VAR_057377"
FT VARIANT 163
FT /note="G -> E (in dbSNP:rs16978965)"
FT /id="VAR_057378"
FT VARIANT 287
FT /note="T -> K (in dbSNP:rs10419604)"
FT /id="VAR_057379"
FT VARIANT 446
FT /note="E -> Q (in dbSNP:rs2722723)"
FT /evidence="ECO:0000269|PubMed:12743021,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.4"
FT /id="VAR_060415"
FT VARIANT 485
FT /note="Y -> H (in dbSNP:rs2722722)"
FT /evidence="ECO:0000269|PubMed:12743021,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.4"
FT /id="VAR_060416"
FT VARIANT 780
FT /note="E -> A (in dbSNP:rs2609881)"
FT /id="VAR_057380"
FT CONFLICT 3..5
FT /note="KFQ -> VSK (in Ref. 1; AAF12816)"
FT /evidence="ECO:0000305"
FT CONFLICT 113
FT /note="A -> T (in Ref. 1; AAF12816)"
FT /evidence="ECO:0000305"
FT CONFLICT 143
FT /note="V -> A (in Ref. 1; AAF12816)"
FT /evidence="ECO:0000305"
FT CONFLICT 222
FT /note="K -> E (in Ref. 1; AAF12816)"
FT /evidence="ECO:0000305"
FT CONFLICT 261
FT /note="T -> S (in Ref. 1; AAF12816)"
FT /evidence="ECO:0000305"
FT CONFLICT 392
FT /note="N -> S (in Ref. 1; AAF12816)"
FT /evidence="ECO:0000305"
FT CONFLICT 813
FT /note="G -> A (in Ref. 1; AAF12816)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 913 AA; 105842 MW; 45F1E5A0EFBDFFC0 CRC64;
MTKFQEMVTF KDVAVVFTEE ELGLLDSVQR KLYRDVMLEN FRNLLLVAHQ PFKPDLISQL
EREEKLLMVE TETPRDGCSG RKNQQKMESI QEVTVSYFSP KELSSRQTWQ QSAGGLIRCQ
DFLKVFQGKN SQLQEQGNSL GQVWAGIPVQ ISEDKNYIFT HIGNGSNYIK SQGYPSWRAH
HSWRKMYLKE SHNYQCRCQQ ISMKNHFCKC DSVSWLSHHN DKLEVHRKEN YSCHDCGEDI
MKVSLLNQES IQTEEKPYPC TGYRKAFSND SSSEVHQQFH LEGKPYTYSS CGKGCNYSSL
LHIHQNIERE DDIENSHLKS YQRVHTEEKP CKCGEYGENF NHCSPLNTYE LIHTGEMSYR
HNIYEKAFSH SLDLNSIFRV HTRDEPHEYE ENENVFNQSS CLQVHQKIHT EEKLYTDIEY
GKSFICSSNL DIQHRVHMEE NSYNSEECGN GFSLASHFQD LQIVHTKEQP YKRYVCSNSF
SHNLYLQGHP KIHIGEKPRK EHGNGFNWSS KLKDHQRVHT GQKPYKCNIC GKGFNHRSVL
NVHQRVHTGE KPYKCEECDK GFSRSSYLQA HQRVHTGEKP YKCEECGKGF SRNSYLQGHQ
RVHTGEKPYK CEECGKGFSR SSHLQGHQRV HTGEKPFKCE ECGKGFSWSF NLQIHQRVHT
GEKPYKCEEC GKGFSKASTL LAHQRVHTGE KPYQCDECGK SFSQRSYLQS HQSVHSGERP
YICEVCGKGF SQRAYLQGHQ RVHTRVKPYK CEMCGKGFSQ SSRLEAHRRV HTGGKPYKCE
VCTKGFSESS RLQAHQRVHV EGRPYKCEQC GKGFSGYSSL QAHHRVHTGE KPYKCEVCGK
GFSQRSNLQA HQRVHTGEKP YKCDACGKGF RWSSGLLIHQ RVHSSDKFYK SEDYGKDYPS
SENLHRNEDS VLF
