ZN112_MOUSE
ID ZN112_MOUSE Reviewed; 879 AA.
AC Q0VAW7; D3Z7D1; E9QP25; Q9R163;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2013, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Zinc finger protein 112 {ECO:0000312|EMBL:AAI20887.1};
DE Short=Zfp-112;
GN Name=Znf112; Synonyms=Zfp112;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAD45928.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=12743021; DOI=10.1101/gr.963903;
RA Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.;
RT "Differential expansion of zinc-finger transcription factor loci in
RT homologous human and mouse gene clusters.";
RL Genome Res. 13:1097-1110(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAI20887.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000269|PubMed:15489334};
CC IsoId=Q0VAW7-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:12743021};
CC IsoId=Q0VAW7-2; Sequence=VSP_052946;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000255}.
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DR EMBL; AF167319; AAD45928.1; -; mRNA.
DR EMBL; AC138791; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC120886; AAI20887.1; -; mRNA.
DR CCDS; CCDS39824.1; -. [Q0VAW7-1]
DR RefSeq; NP_067282.2; NM_021307.2. [Q0VAW7-1]
DR RefSeq; XP_011248963.1; XM_011250661.1.
DR AlphaFoldDB; Q0VAW7; -.
DR SMR; Q0VAW7; -.
DR STRING; 10090.ENSMUSP00000005413; -.
DR iPTMnet; Q0VAW7; -.
DR PhosphoSitePlus; Q0VAW7; -.
DR PaxDb; Q0VAW7; -.
DR PRIDE; Q0VAW7; -.
DR DNASU; 57745; -.
DR Ensembl; ENSMUST00000005413; ENSMUSP00000005413; ENSMUSG00000052675. [Q0VAW7-1]
DR Ensembl; ENSMUST00000120006; ENSMUSP00000113031; ENSMUSG00000052675. [Q0VAW7-2]
DR GeneID; 57745; -.
DR KEGG; mmu:57745; -.
DR UCSC; uc009fou.1; mouse. [Q0VAW7-1]
DR CTD; 57745; -.
DR MGI; MGI:1929115; Zfp112.
DR VEuPathDB; HostDB:ENSMUSG00000052675; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162215; -.
DR HOGENOM; CLU_002678_31_0_1; -.
DR InParanoid; Q0VAW7; -.
DR OMA; LCQVWAG; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q0VAW7; -.
DR TreeFam; TF350845; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 57745; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q0VAW7; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q0VAW7; protein.
DR Bgee; ENSMUSG00000052675; Expressed in metanephric loop of Henle and 98 other tissues.
DR ExpressionAtlas; Q0VAW7; baseline and differential.
DR Genevisible; Q0VAW7; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 10.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..879
FT /note="Zinc finger protein 112"
FT /id="PRO_0000351148"
FT DOMAIN 8..79
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 524..546
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 552..573
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 579..601
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 607..629
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 635..657
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 663..685
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 691..713
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 719..741
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 747..769
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 775..797
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 803..825
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 831..853
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 153..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..6
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12743021"
FT /id="VSP_052946"
FT CONFLICT 155
FT /note="G -> R (in Ref. 1; AAD45928 and 3; AAI20887)"
FT /evidence="ECO:0000305"
FT CONFLICT 272
FT /note="D -> DD (in Ref. 1; AAD45928 and 3; AAI20887)"
FT /evidence="ECO:0000305"
FT CONFLICT 571
FT /note="R -> G (in Ref. 1; AAD45928)"
FT /evidence="ECO:0000305"
FT CONFLICT 738
FT /note="Q -> R (in Ref. 1; AAD45928 and 3; AAI20887)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 879 AA; 98510 MW; 9588BA79A8236383 CRC64;
MTKLQEMVTF RDVAVVFSEE ELGLLDAAQW KLYREVMLEN FRMLLSVAHQ PFKPGLIAQL
ENGEQLWMVE AEAHAGGLSG RRNGHAVENA EDVEVNSLCP EDLSFCQTWP WGACTLPSGQ
EFIKRCQGSN GESQSQEASP RLVWAGMPMQ ISEDGNYGLP PAHEDSASMK NQEFPPPRSQ
QSQGEPYLGR PCVTCQWKGQ QTSIRNHFCR YGSVCWSPYH SDNEELYSKG KSYGFHDDRG
KTVKVLLLNQ DFIELGPEPC PRTKNREAWG HDNDHSSHTH QQCHSRGKPC TRSLSGEGCG
DRSALHGHPG LEAGDEGADG SPPLQSSPRV CMEQVPRECS GNVHYGSPLN TCGCAHPGNT
SQTCSIPKQA VGSPVHCNST FRAHPREEPN NYEENRNVFN QSSCLQVSRK IGAEEKLCQG
VECRKNFTHC SSLNIPHRVP VEETLCNPDC GNHFSLPPHF QDFPGVRARE QPHNRLCRTG
FSQTLCLQGH QKLHIREKPS HREGGSGCNW SSTPKDPQKQ KLHKCNACGK GFSHRSVLDI
HHRIHTGEKP YKCEECGKGF SRSAYLQGHQ RVHTGEKPYK CEECGKGFSR SSHLQGHQRV
HTGEKPYKCE ECGKGFSWSF NLQIHQRVHT GEKPYKCGEC GKGFSKASTL LAHERVHTGE
KPYQCHECGK NFSQKSYLQS HQSVHSGERP HICEVCGKGF SQRAYLQGHL RVHTRVKPYK
CEVCGKGFSQ GSRLEAHQRV HTGRKPFKCE TCTKGFSESS RLQAHQRIHE EGRPYKCDQC
GKGFSGYSSL QAHHRVHTGE KPYKCEVCGK GFSQRSNLQA HQRVHTGEKP YTCDACGKGF
RWSSGLLIHQ RAHSSDTFYR SGECGSSYPP ENLCRNEGL
