ZN114_HUMAN
ID ZN114_HUMAN Reviewed; 417 AA.
AC Q8NC26; A8K6B0; Q08AQ6;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Zinc finger protein 114;
GN Name=ZNF114;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Skeletal muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8NC26; Q86UT8: CENATAC; NbExp=3; IntAct=EBI-10265237, EBI-11028020;
CC Q8NC26; Q8N3C7: CLIP4; NbExp=7; IntAct=EBI-10265237, EBI-5655540;
CC Q8NC26; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-10265237, EBI-14103818;
CC Q8NC26; Q2KHM9: KIAA0753; NbExp=3; IntAct=EBI-10265237, EBI-2805604;
CC Q8NC26; O95198: KLHL2; NbExp=8; IntAct=EBI-10265237, EBI-746999;
CC Q8NC26; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-10265237, EBI-12012928;
CC Q8NC26; Q14244: MAP7; NbExp=3; IntAct=EBI-10265237, EBI-2211064;
CC Q8NC26; Q9UMX1: SUFU; NbExp=3; IntAct=EBI-10265237, EBI-740595;
CC Q8NC26; O94811: TPPP; NbExp=3; IntAct=EBI-10265237, EBI-3927802;
CC Q8NC26; Q8NC26: ZNF114; NbExp=4; IntAct=EBI-10265237, EBI-10265237;
CC Q8NC26; P17098: ZNF8; NbExp=3; IntAct=EBI-10265237, EBI-2555757;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NC26-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NC26-2; Sequence=VSP_024864;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK075062; BAC11378.1; -; mRNA.
DR EMBL; AK291575; BAF84264.1; -; mRNA.
DR EMBL; CH471177; EAW52326.1; -; Genomic_DNA.
DR EMBL; BC125068; AAI25069.1; -; mRNA.
DR EMBL; BC125069; AAI25070.1; -; mRNA.
DR CCDS; CCDS12713.1; -. [Q8NC26-1]
DR RefSeq; NP_001318026.1; NM_001331097.1. [Q8NC26-1]
DR RefSeq; NP_705836.1; NM_153608.3. [Q8NC26-1]
DR AlphaFoldDB; Q8NC26; -.
DR SMR; Q8NC26; -.
DR BioGRID; 127847; 27.
DR IntAct; Q8NC26; 16.
DR STRING; 9606.ENSP00000469998; -.
DR iPTMnet; Q8NC26; -.
DR PhosphoSitePlus; Q8NC26; -.
DR BioMuta; ZNF114; -.
DR DMDM; 74760124; -.
DR EPD; Q8NC26; -.
DR jPOST; Q8NC26; -.
DR MassIVE; Q8NC26; -.
DR MaxQB; Q8NC26; -.
DR PaxDb; Q8NC26; -.
DR PeptideAtlas; Q8NC26; -.
DR PRIDE; Q8NC26; -.
DR ProteomicsDB; 72845; -. [Q8NC26-1]
DR ProteomicsDB; 72846; -. [Q8NC26-2]
DR Antibodypedia; 18297; 106 antibodies from 19 providers.
DR DNASU; 163071; -.
DR Ensembl; ENST00000315849.5; ENSP00000318898.1; ENSG00000178150.10. [Q8NC26-1]
DR Ensembl; ENST00000595607.6; ENSP00000469998.1; ENSG00000178150.10. [Q8NC26-1]
DR Ensembl; ENST00000600687.5; ENSP00000471727.1; ENSG00000178150.10. [Q8NC26-1]
DR GeneID; 163071; -.
DR KEGG; hsa:163071; -.
DR MANE-Select; ENST00000595607.6; ENSP00000469998.1; NM_153608.4; NP_705836.1.
DR UCSC; uc002pil.2; human. [Q8NC26-1]
DR CTD; 163071; -.
DR GeneCards; ZNF114; -.
DR HGNC; HGNC:12894; ZNF114.
DR HPA; ENSG00000178150; Tissue enhanced (thyroid).
DR MIM; 603996; gene.
DR neXtProt; NX_Q8NC26; -.
DR OpenTargets; ENSG00000178150; -.
DR PharmGKB; PA37483; -.
DR VEuPathDB; HostDB:ENSG00000178150; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT01050000244908; -.
DR HOGENOM; CLU_002678_0_2_1; -.
DR InParanoid; Q8NC26; -.
DR OMA; NSIHAVQ; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8NC26; -.
DR TreeFam; TF341761; -.
DR PathwayCommons; Q8NC26; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8NC26; -.
DR BioGRID-ORCS; 163071; 9 hits in 1085 CRISPR screens.
DR GenomeRNAi; 163071; -.
DR Pharos; Q8NC26; Tdark.
DR PRO; PR:Q8NC26; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8NC26; protein.
DR Bgee; ENSG00000178150; Expressed in buccal mucosa cell and 107 other tissues.
DR ExpressionAtlas; Q8NC26; baseline and differential.
DR Genevisible; Q8NC26; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..417
FT /note="Zinc finger protein 114"
FT /id="PRO_0000285296"
FT DOMAIN 6..85
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 304..326
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 332..354
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 361..382
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 388..410
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 95..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..34
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024864"
FT VARIANT 99
FT /note="H -> N (in dbSNP:rs35802964)"
FT /id="VAR_052769"
FT VARIANT 207
FT /note="V -> A (in dbSNP:rs16981956)"
FT /id="VAR_052770"
SQ SEQUENCE 417 AA; 47747 MW; 54A91B16F1E9EC5B CRC64;
MSQDSVTFAD VAVNFTKEEW TLLDPAQRNL YRDVMLENSR NLAFIDWATP CKTKDATPQP
DILPKRTFPE ANRVCLTSIS SQHSTLREDW RCPKTEEPHR QGVNNVKPPA VAPEKDESPV
SICEDHEMRN HSKPTCRLVP SQGDSIRQCI LTRDSSIFKY NPVLNDSQKT HENNEDDGVL
GWNIQWVPCG RKTELKSSTW TGSQNTVHHI RDEIDTGANR HQRNPFGKAF REDGSLRAHN
THGREKMYDF TQCENTSRNN SIHAMQMQLY TAETNKKDCQ TGATSANAPN SGSHKSHCTG
EKTHKCPECG RAFFYQSFLM RHMKIHTGEK PYECGKCGKA FRYSLHLNKH LRKHVVQKKP
YECEECGKVI RESSKYTHIR SHTGEKPYKC KTCGKDFAKS SGLKKHLKTH KDEKPCE
