ZN121_HUMAN
ID ZN121_HUMAN Reviewed; 390 AA.
AC P58317;
DT 18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Zinc finger protein 121;
DE AltName: Full=Zinc finger protein 20;
GN Name=ZNF121; Synonyms=ZNF20;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 96-390.
RX PubMed=8468057; DOI=10.1006/geno.1993.1116;
RA Chen H., Kalaitsidaki M., Warren A.C., Avramopoulos D., Antonarakis S.E.;
RT "A novel zinc finger cDNA with a polymorphic pentanucleotide repeat
RT (ATTTT)n maps on human chromosome 19p.";
RL Genomics 15:621-625(1993).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC P58317; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-1228269, EBI-11530605;
CC P58317; Q14145: KEAP1; NbExp=3; IntAct=EBI-1228269, EBI-751001;
CC P58317; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-1228269, EBI-10171774;
CC P58317; Q9NYW8: RBAK; NbExp=3; IntAct=EBI-1228269, EBI-1210429;
CC P58317; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-1228269, EBI-725997;
CC P58317; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-1228269, EBI-5667516;
CC P58317; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-1228269, EBI-11962574;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AC008759; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M99593; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS32902.1; -.
DR CCDS; CCDS77228.1; -.
DR PIR; A46017; A46017.
DR RefSeq; NP_001008727.1; NM_001008727.3.
DR RefSeq; NP_001295198.1; NM_001308269.1.
DR RefSeq; XP_016882728.1; XM_017027239.1.
DR AlphaFoldDB; P58317; -.
DR SMR; P58317; -.
DR BioGRID; 113474; 45.
DR IntAct; P58317; 23.
DR STRING; 9606.ENSP00000326967; -.
DR iPTMnet; P58317; -.
DR PhosphoSitePlus; P58317; -.
DR BioMuta; ZNF121; -.
DR DMDM; 152031766; -.
DR EPD; P58317; -.
DR jPOST; P58317; -.
DR MassIVE; P58317; -.
DR MaxQB; P58317; -.
DR PaxDb; P58317; -.
DR PeptideAtlas; P58317; -.
DR PRIDE; P58317; -.
DR ProteomicsDB; 57059; -.
DR Antibodypedia; 25051; 40 antibodies from 15 providers.
DR DNASU; 7675; -.
DR Ensembl; ENST00000320451.7; ENSP00000326967.5; ENSG00000197961.12.
DR Ensembl; ENST00000586602.5; ENSP00000468643.1; ENSG00000197961.12.
DR GeneID; 7675; -.
DR KEGG; hsa:7675; -.
DR MANE-Select; ENST00000320451.7; ENSP00000326967.5; NM_001008727.5; NP_001008727.1.
DR UCSC; uc010dwt.3; human.
DR CTD; 7675; -.
DR DisGeNET; 7675; -.
DR GeneCards; ZNF121; -.
DR HGNC; HGNC:12904; ZNF121.
DR HPA; ENSG00000197961; Low tissue specificity.
DR MIM; 194628; gene.
DR neXtProt; NX_P58317; -.
DR OpenTargets; ENSG00000197961; -.
DR PharmGKB; PA37493; -.
DR VEuPathDB; HostDB:ENSG00000197961; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163151; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; P58317; -.
DR OMA; QPNRITH; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P58317; -.
DR TreeFam; TF341966; -.
DR PathwayCommons; P58317; -.
DR SignaLink; P58317; -.
DR BioGRID-ORCS; 7675; 8 hits in 1070 CRISPR screens.
DR ChiTaRS; ZNF121; human.
DR GenomeRNAi; 7675; -.
DR Pharos; P58317; Tdark.
DR PRO; PR:P58317; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P58317; protein.
DR Bgee; ENSG00000197961; Expressed in skin of hip and 187 other tissues.
DR ExpressionAtlas; P58317; baseline and differential.
DR Genevisible; P58317; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..390
FT /note="Zinc finger protein 121"
FT /id="PRO_0000047408"
FT ZN_FING 88..110
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 116..138
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 144..166
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 172..194
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 200..222
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 228..250
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 256..278
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 284..306
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 312..334
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 340..362
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 368..390
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 96..97
FT /note="AF -> NS (in Ref. 2; M99593)"
FT /evidence="ECO:0000305"
FT CONFLICT 212
FT /note="R -> C (in Ref. 2; M99593)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 390 AA; 44694 MW; 5E824D279B5235EE CRC64;
MAEIHNGGEL CDFMENGEIF SEHSCLNAHM GTENTGDTYD CDEYGENFPM LHNSAPAGET
LSVLNQCRKA FSLPPNVHQR TWIGDKSFEY SDCEEAFVDQ SHLQANRITH NGETLYEQKQ
CGRAFTYSTS HAVSVKMHTV EKPYECKECG KFFRYSSYLN SHMRTHTGEK PYECKECGKC
FTVSSHLVEH VRIHTGEKPY QCKECGRAFA GRSGLTKHVR IHTGEKPYEC NECGKAYNRF
YLLTEHFKTH TEEKPFECKV CGKSFRSSSC LKNHFRIHTG IKPYKCKECG KAFTVSSSLH
NHVKIHTGEK PYECKDCGKA FATSSQLIEH IRTHTGEKPY ICKECGKTFR ASSHLQKHVR
IHTGEKPYIC NECGKAYNRF YLLTKHLKTH
