ZN124_HUMAN
ID ZN124_HUMAN Reviewed; 351 AA.
AC Q15973; B3KNP3; J3KSE1; Q15974; Q4VAJ7; Q5T2V4;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 2.
DT 03-AUG-2022, entry version 192.
DE RecName: Full=Zinc finger protein 124;
DE AltName: Full=Zinc finger protein HZF-16;
GN Name=ZNF124;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
RX PubMed=7916577;
RA Saleh M., Selleri L., Evans G.A.;
RT "A novel zinc finger gene on human chromosome 1qter that is alternatively
RT spliced in human tissues and cell lines.";
RL Am. J. Hum. Genet. 52:192-203(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 5).
RC TISSUE=Retinoblastoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q15973; Q9Y4X0-3: AMMECR1; NbExp=3; IntAct=EBI-2555767, EBI-12823597;
CC Q15973; Q9Y2T1: AXIN2; NbExp=3; IntAct=EBI-2555767, EBI-4400025;
CC Q15973; Q9BYV9: BACH2; NbExp=3; IntAct=EBI-2555767, EBI-1642333;
CC Q15973; Q9H2G9: BLZF1; NbExp=3; IntAct=EBI-2555767, EBI-2548012;
CC Q15973; O95273: CCNDBP1; NbExp=3; IntAct=EBI-2555767, EBI-748961;
CC Q15973; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-2555767, EBI-3867333;
CC Q15973; Q9NRI5-2: DISC1; NbExp=3; IntAct=EBI-2555767, EBI-11988027;
CC Q15973; G5E9A7: DMWD; NbExp=3; IntAct=EBI-2555767, EBI-10976677;
CC Q15973; Q5TD97: FHL5; NbExp=3; IntAct=EBI-2555767, EBI-750641;
CC Q15973; Q0VDC6: FKBP1A; NbExp=3; IntAct=EBI-2555767, EBI-10226858;
CC Q15973; O43559: FRS3; NbExp=3; IntAct=EBI-2555767, EBI-725515;
CC Q15973; A1L4K1: FSD2; NbExp=3; IntAct=EBI-2555767, EBI-5661036;
CC Q15973; O76003: GLRX3; NbExp=3; IntAct=EBI-2555767, EBI-374781;
CC Q15973; Q08379: GOLGA2; NbExp=3; IntAct=EBI-2555767, EBI-618309;
CC Q15973; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-2555767, EBI-5916454;
CC Q15973; P28799: GRN; NbExp=3; IntAct=EBI-2555767, EBI-747754;
CC Q15973; P54257: HAP1; NbExp=3; IntAct=EBI-2555767, EBI-712814;
CC Q15973; P54652: HSPA2; NbExp=3; IntAct=EBI-2555767, EBI-356991;
CC Q15973; Q15323: KRT31; NbExp=3; IntAct=EBI-2555767, EBI-948001;
CC Q15973; O76011: KRT34; NbExp=3; IntAct=EBI-2555767, EBI-1047093;
CC Q15973; Q6A162: KRT40; NbExp=3; IntAct=EBI-2555767, EBI-10171697;
CC Q15973; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-2555767, EBI-11959885;
CC Q15973; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-2555767, EBI-10172150;
CC Q15973; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-2555767, EBI-10172290;
CC Q15973; P60410: KRTAP10-8; NbExp=6; IntAct=EBI-2555767, EBI-10171774;
CC Q15973; P60411: KRTAP10-9; NbExp=6; IntAct=EBI-2555767, EBI-10172052;
CC Q15973; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-2555767, EBI-11953334;
CC Q15973; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-2555767, EBI-10172511;
CC Q15973; P26371: KRTAP5-9; NbExp=6; IntAct=EBI-2555767, EBI-3958099;
CC Q15973; O95751: LDOC1; NbExp=3; IntAct=EBI-2555767, EBI-740738;
CC Q15973; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-2555767, EBI-741037;
CC Q15973; Q99750: MDFI; NbExp=6; IntAct=EBI-2555767, EBI-724076;
CC Q15973; P50222: MEOX2; NbExp=3; IntAct=EBI-2555767, EBI-748397;
CC Q15973; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-2555767, EBI-16439278;
CC Q15973; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-2555767, EBI-10172526;
CC Q15973; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-2555767, EBI-11522433;
CC Q15973; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-2555767, EBI-22310682;
CC Q15973; O15294-3: OGT; NbExp=3; IntAct=EBI-2555767, EBI-11536584;
CC Q15973; P26367: PAX6; NbExp=3; IntAct=EBI-2555767, EBI-747278;
CC Q15973; Q5VU43-2: PDE4DIP; NbExp=3; IntAct=EBI-2555767, EBI-9640281;
CC Q15973; D3DTS7: PMP22; NbExp=3; IntAct=EBI-2555767, EBI-25882629;
CC Q15973; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-2555767, EBI-5235340;
CC Q15973; A7MD48: SRRM4; NbExp=3; IntAct=EBI-2555767, EBI-3867173;
CC Q15973; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-2555767, EBI-2212028;
CC Q15973; Q8N0S2: SYCE1; NbExp=3; IntAct=EBI-2555767, EBI-6872807;
CC Q15973; P15884: TCF4; NbExp=3; IntAct=EBI-2555767, EBI-533224;
CC Q15973; P15884-3: TCF4; NbExp=3; IntAct=EBI-2555767, EBI-13636688;
CC Q15973; Q13077: TRAF1; NbExp=6; IntAct=EBI-2555767, EBI-359224;
CC Q15973; Q9BZW7: TSGA10; NbExp=3; IntAct=EBI-2555767, EBI-744794;
CC Q15973; Q9BZL1: UBL5; NbExp=3; IntAct=EBI-2555767, EBI-607755;
CC Q15973; O76024: WFS1; NbExp=3; IntAct=EBI-2555767, EBI-720609;
CC Q15973; Q8TF50: ZNF526; NbExp=3; IntAct=EBI-2555767, EBI-11035148;
CC Q15973; Q6AZW8: ZNF660; NbExp=3; IntAct=EBI-2555767, EBI-12376497;
CC Q15973; Q96EG3: ZNF837; NbExp=6; IntAct=EBI-2555767, EBI-11962574;
CC Q15973; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-2555767, EBI-527853;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q15973-3; Sequence=Displayed;
CC Name=2;
CC IsoId=Q15973-4; Sequence=VSP_015692;
CC Name=3; Synonyms=HZF-16.2;
CC IsoId=Q15973-1; Sequence=VSP_015691;
CC Name=4; Synonyms=HZF-16.1;
CC IsoId=Q15973-2; Sequence=VSP_015691, VSP_006895;
CC Name=5;
CC IsoId=Q15973-5; Sequence=VSP_046852;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; S54641; AAB25346.1; -; mRNA.
DR EMBL; S54641; AAB25347.1; -; mRNA.
DR EMBL; AK054647; BAG51405.1; -; mRNA.
DR EMBL; AL390728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471148; EAW77169.1; -; Genomic_DNA.
DR EMBL; BC032514; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC096349; AAH96349.1; -; mRNA.
DR EMBL; BC096350; AAH96350.1; -; mRNA.
DR EMBL; BC096351; AAH96351.1; -; mRNA.
DR EMBL; BC099661; AAH99661.1; -; mRNA.
DR CCDS; CCDS31089.1; -. [Q15973-4]
DR CCDS; CCDS58067.1; -. [Q15973-5]
DR CCDS; CCDS73057.1; -. [Q15973-3]
DR PIR; A45447; A45447.
DR PIR; B45447; B45447.
DR RefSeq; NP_001230669.1; NM_001243740.2. [Q15973-5]
DR RefSeq; NP_001284497.1; NM_001297568.1. [Q15973-3]
DR RefSeq; NP_001284498.1; NM_001297569.1.
DR RefSeq; NP_003422.2; NM_003431.3. [Q15973-4]
DR AlphaFoldDB; Q15973; -.
DR SMR; Q15973; -.
DR BioGRID; 113476; 59.
DR IntAct; Q15973; 59.
DR STRING; 9606.ENSP00000440365; -.
DR iPTMnet; Q15973; -.
DR PhosphoSitePlus; Q15973; -.
DR BioMuta; ZNF124; -.
DR DMDM; 76803836; -.
DR EPD; Q15973; -.
DR jPOST; Q15973; -.
DR MassIVE; Q15973; -.
DR MaxQB; Q15973; -.
DR PeptideAtlas; Q15973; -.
DR PRIDE; Q15973; -.
DR ProteomicsDB; 60824; -. [Q15973-3]
DR ProteomicsDB; 60825; -. [Q15973-1]
DR ProteomicsDB; 60826; -. [Q15973-2]
DR ProteomicsDB; 60827; -. [Q15973-4]
DR Antibodypedia; 20838; 168 antibodies from 25 providers.
DR DNASU; 7678; -.
DR Ensembl; ENST00000340684.10; ENSP00000340749.6; ENSG00000196418.13. [Q15973-4]
DR Ensembl; ENST00000472531.5; ENSP00000462445.1; ENSG00000196418.13. [Q15973-5]
DR Ensembl; ENST00000543802.3; ENSP00000440365.2; ENSG00000196418.13. [Q15973-3]
DR GeneID; 7678; -.
DR KEGG; hsa:7678; -.
DR MANE-Select; ENST00000543802.3; ENSP00000440365.2; NM_001297568.2; NP_001284497.1.
DR UCSC; uc001ici.4; human. [Q15973-3]
DR CTD; 7678; -.
DR DisGeNET; 7678; -.
DR GeneCards; ZNF124; -.
DR HGNC; HGNC:12907; ZNF124.
DR HPA; ENSG00000196418; Tissue enhanced (salivary).
DR MIM; 194631; gene.
DR neXtProt; NX_Q15973; -.
DR OpenTargets; ENSG00000196418; -.
DR PharmGKB; PA37496; -.
DR VEuPathDB; HostDB:ENSG00000196418; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164793; -.
DR HOGENOM; CLU_002678_69_14_1; -.
DR InParanoid; Q15973; -.
DR OMA; HYSCTIC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q15973; -.
DR TreeFam; TF338854; -.
DR PathwayCommons; Q15973; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q15973; -.
DR BioGRID-ORCS; 7678; 14 hits in 1101 CRISPR screens.
DR ChiTaRS; ZNF124; human.
DR GenomeRNAi; 7678; -.
DR Pharos; Q15973; Tbio.
DR PRO; PR:Q15973; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q15973; protein.
DR Bgee; ENSG00000196418; Expressed in colonic epithelium and 158 other tissues.
DR ExpressionAtlas; Q15973; baseline and differential.
DR Genevisible; Q15973; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; TAS:ProtInc.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..351
FT /note="Zinc finger protein 124"
FT /id="PRO_0000047410"
FT DOMAIN 13..106
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 122..144
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 150..172
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 178..200
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 206..228
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 234..256
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 262..284
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 290..312
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 318..340
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..72
FT /note="MSGHPGSWEMNSVAFEDVAVNFTQEEWALLDPSQKNLYRDVMQETFRNLASI
FT GNKGEDQSIEDQYKNSSRNL -> MNALCVKNSSYVHSSLH (in isoform 3 and
FT isoform 4)"
FT /evidence="ECO:0000303|PubMed:7916577"
FT /id="VSP_015691"
FT VAR_SEQ 73..134
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_015692"
FT VAR_SEQ 74..351
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_046852"
FT VAR_SEQ 190..329
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:7916577"
FT /id="VSP_006895"
SQ SEQUENCE 351 AA; 40217 MW; 9C6C2E4DC3B61FF2 CRC64;
MSGHPGSWEM NSVAFEDVAV NFTQEEWALL DPSQKNLYRD VMQETFRNLA SIGNKGEDQS
IEDQYKNSSR NLRHIISHSG NNPYGCEECG KKPCTCKQCQ KTSLSVTRVH RDTVMHTGNG
HYGCTICEKV FNIPSSFQIH QRNHTGEKPY ECMECGKALG FSRSLNRHKR IHTGEKRYEC
KQCGKAFSRS SHLRDHERTH TGEKPYECKH CGKAFRYSNC LHYHERTHTG EKPYVCMECG
KAFSCLSSLQ GHIKAHAGEE PYPCKQCGKA FRYASSLQKH EKTHIAQKPY VCNNCGKGFR
CSSSLRDHER THTGEKPYEC QKCGKAFSRA STLWKHKKTH TGEKPYKCKK M
