ZN132_HUMAN
ID ZN132_HUMAN Reviewed; 706 AA.
AC P52740; Q32MI9;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 181.
DE RecName: Full=Zinc finger protein 132;
GN Name=ZNF132;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Insulinoma;
RX PubMed=7557990; DOI=10.1006/geno.1995.1040;
RA Tommerup N., Vissing H.;
RT "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs
RT identify putative candidate genes for developmental and malignant
RT disorders.";
RL Genomics 27:259-264(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P52740-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P52740-2; Sequence=VSP_035665;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; U09411; AAC50252.1; -; mRNA.
DR EMBL; AC012313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471135; EAW72591.1; -; Genomic_DNA.
DR EMBL; BC109107; AAI09108.1; -; mRNA.
DR EMBL; BC109108; AAI09109.1; -; mRNA.
DR CCDS; CCDS12980.1; -. [P52740-1]
DR PIR; I38598; I38598.
DR RefSeq; NP_003424.3; NM_003433.3. [P52740-1]
DR AlphaFoldDB; P52740; -.
DR SMR; P52740; -.
DR IntAct; P52740; 1.
DR STRING; 9606.ENSP00000254166; -.
DR iPTMnet; P52740; -.
DR PhosphoSitePlus; P52740; -.
DR BioMuta; ZNF132; -.
DR DMDM; 212276481; -.
DR jPOST; P52740; -.
DR MassIVE; P52740; -.
DR MaxQB; P52740; -.
DR PaxDb; P52740; -.
DR PeptideAtlas; P52740; -.
DR PRIDE; P52740; -.
DR ProteomicsDB; 56514; -. [P52740-1]
DR ProteomicsDB; 56515; -. [P52740-2]
DR Antibodypedia; 1787; 86 antibodies from 16 providers.
DR DNASU; 7691; -.
DR Ensembl; ENST00000254166.4; ENSP00000254166.2; ENSG00000131849.13. [P52740-1]
DR GeneID; 7691; -.
DR KEGG; hsa:7691; -.
DR MANE-Select; ENST00000254166.4; ENSP00000254166.2; NM_003433.4; NP_003424.3.
DR UCSC; uc002qst.4; human. [P52740-1]
DR CTD; 7691; -.
DR DisGeNET; 7691; -.
DR GeneCards; ZNF132; -.
DR HGNC; HGNC:12916; ZNF132.
DR HPA; ENSG00000131849; Low tissue specificity.
DR MIM; 604074; gene.
DR neXtProt; NX_P52740; -.
DR OpenTargets; ENSG00000131849; -.
DR PharmGKB; PA37505; -.
DR VEuPathDB; HostDB:ENSG00000131849; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163387; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; P52740; -.
DR PhylomeDB; P52740; -.
DR TreeFam; TF339848; -.
DR PathwayCommons; P52740; -.
DR SignaLink; P52740; -.
DR BioGRID-ORCS; 7691; 11 hits in 1096 CRISPR screens.
DR ChiTaRS; ZNF132; human.
DR GenomeRNAi; 7691; -.
DR Pharos; P52740; Tbio.
DR PRO; PR:P52740; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P52740; protein.
DR Bgee; ENSG00000131849; Expressed in ventricular zone and 98 other tissues.
DR ExpressionAtlas; P52740; baseline and differential.
DR Genevisible; P52740; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 13.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 17.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 10.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 17.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 18.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..706
FT /note="Zinc finger protein 132"
FT /id="PRO_0000047416"
FT DOMAIN 38..121
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 114..136
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 142..164
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 236..258
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 291..313
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 319..341
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 347..369
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 375..397
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 403..425
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 431..453
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 459..481
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 487..509
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 515..537
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 543..565
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 571..593
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 599..621
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 627..649
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 655..677
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 683..705
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..117
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:7557990"
FT /id="VSP_035665"
FT VARIANT 203
FT /note="G -> D (in dbSNP:rs1122955)"
FT /id="VAR_047229"
FT VARIANT 252
FT /note="P -> L (in dbSNP:rs1465789)"
FT /id="VAR_012024"
SQ SEQUENCE 706 AA; 80623 MW; 7C74CEF0C0701AC3 CRC64;
MALPSPQVLM GLPALLMGPA QHTSWPCGSA VPTLKSMVTF EDVAVYFSQE EWELLDAAQR
HLYHSVMLEN LELVTSLGSW HGVEGEGAHP KQNVSVEVLQ VRIPNADPST KKANSCDMCG
PFLKDILHLA EHQGTQSEEK PYTCGACGRD FWLNANLHQH QKEHSGGKPF RWYKDRDALM
KSSKVHLSEN PFTCREGGKV ILGSCDLLQL QAVDSGQKPY SNLGQLPEVC TTQKLFECSN
CGKAFLKSST LPNHLRTHSE EIPFTCPTGG NFLEEKSILG NKKFHTGEIP HVCKECGKAF
SHSSKLRKHQ KFHTEVKYYE CIACGKTFNH KLTFVHHQRI HSGERPYECD ECGKAFSNRS
HLIRHEKVHT GERPFECLKC GRAFSQSSNF LRHQKVHTQV RPYECSQCGK SFSRSSALIQ
HWRVHTGERP YECSECGRAF NNNSNLAQHQ KVHTGERPFE CSECGRDFSQ SSHLLRHQKV
HTGERPFECC DCGKAFSNSS TLIQHQKVHT GQRPYECSEC RKSFSRSSSL IQHWRIHTGE
KPYECSECGK AFAHSSTLIE HWRVHTKERP YECNECGKFF SQNSILIKHQ KVHTGEKPYK
CSECGKFFSR KSSLICHWRV HTGERPYECS ECGRAFSSNS HLVRHQRVHT QERPYECIQC
GKAFSERSTL VRHQKVHTRE RTYECSQCGK LFSHLCNLAQ HKKIHT
