ZN133_HUMAN
ID ZN133_HUMAN Reviewed; 654 AA.
AC P52736; A8K5S4; B4DHU7; B4DIB8; B7ZAS1; F5H289; J3KQ11; J3KQJ0; Q53XU1;
AC Q5JXV8; Q9BUV2; Q9H443;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 202.
DE RecName: Full=Zinc finger protein 133;
DE AltName: Full=Zinc finger protein 150;
GN Name=ZNF133; Synonyms=ZNF150;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT THR-193.
RC TISSUE=Insulinoma;
RX PubMed=7649249; DOI=10.1016/0014-5793(95)00728-r;
RA Vissing H., Meyer W.-K., Aagaard L., Tommerup N., Thiesen H.-J.;
RT "Repression of transcriptional activity by heterologous KRAB domains
RT present in zinc finger proteins.";
RL FEBS Lett. 369:153-157(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT THR-193.
RC TISSUE=Insulinoma;
RX PubMed=7557990; DOI=10.1006/geno.1995.1040;
RA Tommerup N., Vissing H.;
RT "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs
RT identify putative candidate genes for developmental and malignant
RT disorders.";
RL Genomics 27:259-264(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT THR-193.
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3; 4 AND 5), AND
RP VARIANT THR-193.
RC TISSUE=Brain, Caudate nucleus, Hippocampus, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT THR-193.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT THR-193.
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-310; LYS-338; LYS-506; LYS-576;
RP LYS-604 AND LYS-618, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May be involved in transcriptional regulation as a repressor.
CC -!- INTERACTION:
CC P52736; P01100: FOS; NbExp=4; IntAct=EBI-2687350, EBI-852851;
CC P52736; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-2687350, EBI-10172290;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=P52736-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P52736-2; Sequence=VSP_039148;
CC Name=3;
CC IsoId=P52736-3; Sequence=VSP_055021;
CC Name=4;
CC IsoId=P52736-4; Sequence=VSP_055022;
CC Name=5;
CC IsoId=P52736-5; Sequence=VSP_055023;
CC -!- TISSUE SPECIFICITY: Seems ubiquitous. Seen in the heart, brain,
CC placenta, lung, liver, skeletal muscle, kidney and pancreas.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; U09366; AAC50260.1; -; mRNA.
DR EMBL; BT007310; AAP35974.1; -; mRNA.
DR EMBL; AK291389; BAF84078.1; -; mRNA.
DR EMBL; AK295273; BAG58259.1; -; mRNA.
DR EMBL; AK295513; BAG58430.1; -; mRNA.
DR EMBL; AK316386; BAH14757.1; -; mRNA.
DR EMBL; AL049646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471133; EAX10250.1; -; Genomic_DNA.
DR EMBL; CH471133; EAX10251.1; -; Genomic_DNA.
DR EMBL; CH471133; EAX10252.1; -; Genomic_DNA.
DR EMBL; CH471133; EAX10253.1; -; Genomic_DNA.
DR EMBL; BC001887; AAH01887.1; -; mRNA.
DR CCDS; CCDS13134.1; -. [P52736-2]
DR CCDS; CCDS63233.1; -. [P52736-5]
DR CCDS; CCDS63234.1; -. [P52736-1]
DR CCDS; CCDS63235.1; -. [P52736-4]
DR CCDS; CCDS74703.1; -. [P52736-3]
DR CCDS; CCDS74704.1; -. [P52736-3]
DR PIR; A57785; A57785.
DR RefSeq; NP_001076799.1; NM_001083330.2. [P52736-2]
DR RefSeq; NP_001269924.1; NM_001282995.1. [P52736-2]
DR RefSeq; NP_001269926.1; NM_001282997.1. [P52736-1]
DR RefSeq; NP_001269927.1; NM_001282998.1. [P52736-1]
DR RefSeq; NP_001269928.1; NM_001282999.1. [P52736-1]
DR RefSeq; NP_001269929.1; NM_001283000.1. [P52736-1]
DR RefSeq; NP_001269930.1; NM_001283001.1. [P52736-1]
DR RefSeq; NP_001269937.1; NM_001283008.1. [P52736-3]
DR RefSeq; NP_003425.2; NM_003434.5. [P52736-2]
DR RefSeq; XP_005260876.1; XM_005260819.1.
DR RefSeq; XP_005260877.1; XM_005260820.4.
DR RefSeq; XP_011527638.1; XM_011529336.1.
DR RefSeq; XP_011527639.1; XM_011529337.1. [P52736-1]
DR RefSeq; XP_011527640.1; XM_011529338.2.
DR RefSeq; XP_011527641.1; XM_011529339.1. [P52736-1]
DR RefSeq; XP_016883530.1; XM_017028041.1. [P52736-5]
DR RefSeq; XP_016883531.1; XM_017028042.1. [P52736-5]
DR RefSeq; XP_016883533.1; XM_017028044.1.
DR RefSeq; XP_016883534.1; XM_017028045.1.
DR RefSeq; XP_016883535.1; XM_017028046.1.
DR RefSeq; XP_016883536.1; XM_017028047.1. [P52736-1]
DR RefSeq; XP_016883537.1; XM_017028048.1. [P52736-1]
DR RefSeq; XP_016883538.1; XM_017028049.1.
DR RefSeq; XP_016883539.1; XM_017028050.1.
DR RefSeq; XP_016883540.1; XM_017028051.1.
DR RefSeq; XP_016883541.1; XM_017028052.1.
DR RefSeq; XP_016883542.1; XM_017028053.1.
DR RefSeq; XP_016883543.1; XM_017028054.1.
DR RefSeq; XP_016883544.1; XM_017028055.1.
DR RefSeq; XP_016883545.1; XM_017028056.1.
DR RefSeq; XP_016883546.1; XM_017028057.1.
DR AlphaFoldDB; P52736; -.
DR SMR; P52736; -.
DR BioGRID; 113487; 27.
DR IntAct; P52736; 22.
DR MINT; P52736; -.
DR STRING; 9606.ENSP00000439427; -.
DR iPTMnet; P52736; -.
DR PhosphoSitePlus; P52736; -.
DR BioMuta; ZNF133; -.
DR DMDM; 116242855; -.
DR MassIVE; P52736; -.
DR MaxQB; P52736; -.
DR PaxDb; P52736; -.
DR PeptideAtlas; P52736; -.
DR PRIDE; P52736; -.
DR ProteomicsDB; 25897; -.
DR ProteomicsDB; 56508; -. [P52736-1]
DR ProteomicsDB; 56509; -. [P52736-2]
DR Antibodypedia; 814; 183 antibodies from 19 providers.
DR DNASU; 7692; -.
DR Ensembl; ENST00000316358.8; ENSP00000346090.3; ENSG00000125846.16. [P52736-1]
DR Ensembl; ENST00000377671.7; ENSP00000366899.3; ENSG00000125846.16. [P52736-2]
DR Ensembl; ENST00000396026.7; ENSP00000400897.3; ENSG00000125846.16. [P52736-2]
DR Ensembl; ENST00000401790.5; ENSP00000383945.1; ENSG00000125846.16. [P52736-1]
DR Ensembl; ENST00000402618.6; ENSP00000385279.2; ENSG00000125846.16. [P52736-4]
DR Ensembl; ENST00000425686.3; ENSP00000406638.2; ENSG00000125846.16. [P52736-1]
DR Ensembl; ENST00000622607.4; ENSP00000481326.1; ENSG00000125846.16. [P52736-1]
DR Ensembl; ENST00000628216.2; ENSP00000487315.1; ENSG00000125846.16. [P52736-5]
DR Ensembl; ENST00000630056.1; ENSP00000485741.1; ENSG00000125846.16. [P52736-3]
DR GeneID; 7692; -.
DR KEGG; hsa:7692; -.
DR MANE-Select; ENST00000425686.3; ENSP00000406638.2; NM_001352452.2; NP_001339381.2.
DR UCSC; uc002wql.6; human. [P52736-1]
DR CTD; 7692; -.
DR DisGeNET; 7692; -.
DR GeneCards; ZNF133; -.
DR HGNC; HGNC:12917; ZNF133.
DR HPA; ENSG00000125846; Low tissue specificity.
DR MIM; 604075; gene.
DR neXtProt; NX_P52736; -.
DR OpenTargets; ENSG00000125846; -.
DR PharmGKB; PA134900961; -.
DR VEuPathDB; HostDB:ENSG00000125846; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162260; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; P52736; -.
DR OMA; CKECGWC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P52736; -.
DR TreeFam; TF338096; -.
DR PathwayCommons; P52736; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; P52736; -.
DR BioGRID-ORCS; 7692; 64 hits in 1108 CRISPR screens.
DR ChiTaRS; ZNF133; human.
DR GeneWiki; ZNF133; -.
DR GenomeRNAi; 7692; -.
DR Pharos; P52736; Tbio.
DR PRO; PR:P52736; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; P52736; protein.
DR Bgee; ENSG00000125846; Expressed in cerebellar hemisphere and 184 other tissues.
DR ExpressionAtlas; P52736; baseline and differential.
DR Genevisible; P52736; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:ProtInc.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:ARUK-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 13.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation; Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..654
FT /note="Zinc finger protein 133"
FT /id="PRO_0000047417"
FT DOMAIN 1..72
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 214..236
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 242..264
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 270..292
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 298..320
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 326..348
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 354..376
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 382..404
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 410..432
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 438..460
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 466..488
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 494..516
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 522..544
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 550..572
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 578..600
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 606..631
FT /note="C2H2-type 15; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 119..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 622..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 310
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 338
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 506
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 576
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 604
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 618
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 1..95
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055021"
FT VAR_SEQ 1..72
FT /note="MAFRDVAVDFTQDEWRLLSPAQRTLYREVMLENYSNLVSLGISFSKPELITQ
FT LEQGKETWREEKKCSPATCP -> MCNGRKTVL (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055022"
FT VAR_SEQ 1
FT /note="M -> MAHM (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055023"
FT VAR_SEQ 73
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|Ref.3"
FT /id="VSP_039148"
FT VARIANT 193
FT /note="S -> T (in dbSNP:rs1033545)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:7557990,
FT ECO:0000269|PubMed:7649249, ECO:0000269|Ref.3,
FT ECO:0000269|Ref.6"
FT /id="VAR_028228"
FT VARIANT 194
FT /note="G -> E (in dbSNP:rs2228273)"
FT /id="VAR_028229"
FT CONFLICT 228
FT /note="N -> S (in Ref. 4; BAG58259)"
FT /evidence="ECO:0000305"
FT CONFLICT 363
FT /note="F -> Y (in Ref. 4; BAG58430)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 654 AA; 73388 MW; CF1D47B223A6DD84 CRC64;
MAFRDVAVDF TQDEWRLLSP AQRTLYREVM LENYSNLVSL GISFSKPELI TQLEQGKETW
REEKKCSPAT CPADPEPELY LDPFCPPGFS SQKFPMQHVL CNHPPWIFTC LCAEGNIQPG
DPGPGDQEKQ QQASEGRPWS DQAEGPEGEG AMPLFGRTKK RTLGAFSRPP QRQPVSSRNG
LRGVELEASP AQSGNPEETD KLLKRIEVLG FGTVNCGECG LSFSKMTNLL SHQRIHSGEK
PYVCGVCEKG FSLKKSLARH QKAHSGEKPI VCRECGRGFN RKSTLIIHER THSGEKPYMC
SECGRGFSQK SNLIIHQRTH SGEKPYVCRE CGKGFSQKSA VVRHQRTHLE EKTIVCSDCG
LGFSDRSNLI SHQRTHSGEK PYACKECGRC FRQRTTLVNH QRTHSKEKPY VCGVCGHSFS
QNSTLISHRR THTGEKPYVC GVCGRGFSLK SHLNRHQNIH SGEKPIVCKD CGRGFSQQSN
LIRHQRTHSG EKPMVCGECG RGFSQKSNLV AHQRTHSGER PYVCRECGRG FSHQAGLIRH
KRKHSREKPY MCRQCGLGFG NKSALITHKR AHSEEKPCVC RECGQGFLQK SHLTLHQMTH
TGEKPYVCKT CGRGFSLKSH LSRHRKTTSV HHRLPVQPDP EPCAGQPSDS LYSL
