ZN135_BOVIN
ID ZN135_BOVIN Reviewed; 657 AA.
AC Q08DG8;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Zinc finger protein 135;
GN Name=ZNF135;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal muscle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in the regulation of cell morphology and
CC cytoskeletal organization. May be involved in transcriptional
CC regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; BC123758; AAI23759.1; -; mRNA.
DR RefSeq; NP_001070284.1; NM_001076816.1.
DR AlphaFoldDB; Q08DG8; -.
DR SMR; Q08DG8; -.
DR STRING; 9913.ENSBTAP00000004502; -.
DR PaxDb; Q08DG8; -.
DR Ensembl; ENSBTAT00000004502; ENSBTAP00000004502; ENSBTAG00000003462.
DR GeneID; 508062; -.
DR KEGG; bta:508062; -.
DR CTD; 7694; -.
DR VEuPathDB; HostDB:ENSBTAG00000003462; -.
DR VGNC; VGNC:37209; ZNF135.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000153104; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q08DG8; -.
DR OMA; TCAKEKP; -.
DR OrthoDB; 1318335at2759; -.
DR TreeFam; TF350822; -.
DR Reactome; R-BTA-212436; Generic Transcription Pathway.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000003462; Expressed in oocyte and 106 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
DR GO; GO:0022604; P:regulation of cell morphogenesis; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 16.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 16.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 16.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 16.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..657
FT /note="Zinc finger protein 135"
FT /id="PRO_0000308708"
FT DOMAIN 14..85
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 213..235
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 241..263
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 269..291
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 297..319
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 325..347
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 353..375
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 381..403
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 409..431
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 437..459
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 465..487
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 493..515
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 521..543
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 549..571
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 577..599
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 605..627
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 633..655
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 155..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 657 AA; 73944 MW; 08688368BA71026D CRC64;
MTAGLLTAGD PDQVTFEDVV VDFTQEEWGH LEPAQRTLYR DVMLETFGLL VSVGHWLPKP
DVISLLEQEA ELWAADKGGP RGVCPDLETR PQSKLSTENQ GVTEEIPNSA LVERFLQESL
WHSKDEGAAG HREQGPEKSD SCVVQAACTL VKTLTEEQQQ GDGCGENLSL RPDLPTQPMT
PERQGAPTWG THGQRENPDS NAQQKTCAKE KPYGCQECGK AFSHSLALIE HHRTHTGERP
YECPECGKGF RNSSALTKHQ RIHTGEKPYK CAQCGRTFNQ IAPLIQHQRT HTGEKPYECS
ECGKSFSFRS SFSQHERTHT GEKPYTCSQC GKAFRQSIHL TQHLRIHTGE KPYQCGECGK
AFSHSSSLTK HQRIHTGEKP YECQACGKAF TQITPLIQHQ RIHTGERPYE CSECGRAFSQ
STLLTEHRRI HTGEKPYGCN ECGKAFSHSS SLSQHERTHT GEKPYACSQC GKAFRQSTHL
TQHQRTHTGE KPYECSDCGK AFSHSSSLTK HQRIHTGEKP YECNECGKAF SQLAPLIQHQ
RIHTGEKPYE CNQCGRAFSQ SSLLIEHQRI HTKEKPYGCN ECGKSFSHSS SLSQHERTHT
GEKPYDCQDC GKSFRQRTHL TQHQRIHTGE KPYECRDCGK AFTHSSSFIK HQRTHTG
