ZN137_HUMAN
ID ZN137_HUMAN Reviewed; 207 AA.
AC P52743; Q2TBC7;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 144.
DE RecName: Full=Putative zinc finger protein 137;
DE AltName: Full=Zinc finger protein 137 pseudogene;
GN Name=ZNF137P; Synonyms=ZNF137;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Insulinoma;
RX PubMed=7557990; DOI=10.1006/geno.1995.1040;
RA Tommerup N., Vissing H.;
RT "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs
RT identify putative candidate genes for developmental and malignant
RT disorders.";
RL Genomics 27:259-264(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- CAUTION: Product of a dubious CDS prediction. May be produced at very
CC low levels due to a premature stop codon in the mRNA, leading to
CC nonsense-mediated mRNA decay. {ECO:0000305}.
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DR EMBL; U09414; AAC50255.1; -; mRNA.
DR EMBL; AC022150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC110456; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; I38602; I38602.
DR AlphaFoldDB; P52743; -.
DR SMR; P52743; -.
DR iPTMnet; P52743; -.
DR PhosphoSitePlus; P52743; -.
DR BioMuta; HGNC:12921; -.
DR DMDM; 1731413; -.
DR jPOST; P52743; -.
DR MassIVE; P52743; -.
DR MaxQB; P52743; -.
DR PeptideAtlas; P52743; -.
DR PRIDE; P52743; -.
DR ProteomicsDB; 56519; -.
DR GeneCards; ZNF137P; -.
DR HGNC; HGNC:12921; ZNF137P.
DR MIM; 604079; gene.
DR neXtProt; NX_P52743; -.
DR InParanoid; P52743; -.
DR PhylomeDB; P52743; -.
DR PathwayCommons; P52743; -.
DR Pharos; P52743; Tdark.
DR PRO; PR:P52743; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P52743; protein.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 5: Uncertain;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..207
FT /note="Putative zinc finger protein 137"
FT /id="PRO_0000047421"
FT ZN_FING 72..94
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 100..122
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 128..150
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 156..178
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 184..206
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 112
FT /note="R -> Q (in dbSNP:rs7250969)"
FT /id="VAR_033556"
FT VARIANT 181
FT /note="Q -> H (in dbSNP:rs1802617)"
FT /id="VAR_012025"
SQ SEQUENCE 207 AA; 24115 MW; 44581FE39D47AA7A CRC64;
MNVARFLVEK HTLHVIIDFI LSKVSNQQSN LAQHQRVYTG EKPYKCNEWG KALSGKSSLF
YHQAIHGVGK LCKCNDCHKV FSNATTIANH WRIHNEDRSY KCNKCGKIFR HRSYLAVYQR
THTGEKPYKY HDCGKVFSQA SSYAKHRRIH TGEKPHKCDD CGKVLTSRSH LIRHQRIHTG
QKSYKCLKCG KVFSLWALHA EHQKIHF
