ZN142_HUMAN
ID ZN142_HUMAN Reviewed; 1687 AA.
AC P52746; Q92510;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 4.
DT 03-AUG-2022, entry version 182.
DE RecName: Full=Zinc finger protein 142 {ECO:0000305};
GN Name=ZNF142 {ECO:0000303|PubMed:7557990, ECO:0000312|HGNC:HGNC:12927};
GN Synonyms=KIAA0236 {ECO:0000303|PubMed:9039502};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-751.
RC TISSUE=Bone marrow;
RX PubMed=9039502; DOI=10.1093/dnares/3.5.321;
RA Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O.,
RA Tanaka A., Kotani H., Miyajima N., Nomura N.;
RT "Prediction of the coding sequences of unidentified human genes. VI. The
RT coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of
RT cDNA clones from cell line KG-1 and brain.";
RL DNA Res. 3:321-329(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 460-632.
RC TISSUE=Insulinoma;
RX PubMed=7557990; DOI=10.1006/geno.1995.1040;
RA Tommerup N., Vissing H.;
RT "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs
RT identify putative candidate genes for developmental and malignant
RT disorders.";
RL Genomics 27:259-264(1995).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-154, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [5]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-594, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25218447; DOI=10.1038/nsmb.2890;
RA Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M.,
RA Vertegaal A.C.;
RT "Uncovering global SUMOylation signaling networks in a site-specific
RT manner.";
RL Nat. Struct. Mol. Biol. 21:927-936(2014).
RN [6]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-1193; LYS-1242 AND LYS-1591, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
RN [7]
RP INVOLVEMENT IN NEDISHM, AND VARIANTS NEDISHM 1059-ARG--GLY-1687 DEL;
RP PHE-1233; 1395-LEU--GLY-1687 DEL AND THR-1500.
RX PubMed=31036918; DOI=10.1038/s41436-019-0523-0;
RA Khan K., Zech M., Morgan A.T., Amor D.J., Skorvanek M., Khan T.N.,
RA Hildebrand M.S., Jackson V.E., Scerri T.S., Coleman M., Rigbye K.A.,
RA Scheffer I.E., Bahlo M., Wagner M., Lam D.D., Berutti R., Havrankova P.,
RA Fecikova A., Strom T.M., Han V., Dosekova P., Gdovinova Z., Laccone F.,
RA Jameel M., Mooney M.R., Baig S.M., Jech R., Davis E.E., Katsanis N.,
RA Winkelmann J.;
RT "Recessive variants in ZNF142 cause a complex neurodevelopmental disorder
RT with intellectual disability, speech impairment, seizures, and dystonia.";
RL Genet. Med. 21:2532-2542(2019).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DISEASE: Neurodevelopmental disorder with impaired speech and
CC hyperkinetic movements (NEDISHM) [MIM:618425]: An autosomal recessive
CC disorder characterized by global developmental delay, impaired
CC intellectual development, delayed walking, poor or absent speech, and a
CC hyperkinetic movement disorder with dystonia, tremor, ataxia, or
CC chorea. Some patients develop seizures. {ECO:0000269|PubMed:31036918}.
CC Note=The disease is caused by variants affecting the gene represented
CC in this entry.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA13242.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; D87073; BAA13242.2; ALT_INIT; mRNA.
DR EMBL; AC012510; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; U09849; AAC50265.1; -; mRNA.
DR CCDS; CCDS42817.1; -.
DR PIR; I38617; I38617.
DR RefSeq; NP_001099007.1; NM_001105537.2.
DR RefSeq; XP_011510091.1; XM_011511789.2.
DR RefSeq; XP_016860361.1; XM_017004872.1.
DR AlphaFoldDB; P52746; -.
DR BioGRID; 113495; 19.
DR IntAct; P52746; 7.
DR STRING; 9606.ENSP00000398798; -.
DR iPTMnet; P52746; -.
DR PhosphoSitePlus; P52746; -.
DR BioMuta; ZNF142; -.
DR DMDM; 313104298; -.
DR jPOST; P52746; -.
DR MassIVE; P52746; -.
DR MaxQB; P52746; -.
DR PaxDb; P52746; -.
DR PeptideAtlas; P52746; -.
DR PRIDE; P52746; -.
DR ProteomicsDB; 56521; -.
DR Antibodypedia; 56468; 26 antibodies from 10 providers.
DR DNASU; 7701; -.
DR Ensembl; ENST00000449707.5; ENSP00000408643.1; ENSG00000115568.16.
DR GeneID; 7701; -.
DR KEGG; hsa:7701; -.
DR UCSC; uc002vin.6; human.
DR CTD; 7701; -.
DR DisGeNET; 7701; -.
DR GeneCards; ZNF142; -.
DR HGNC; HGNC:12927; ZNF142.
DR HPA; ENSG00000115568; Low tissue specificity.
DR MalaCards; ZNF142; -.
DR MIM; 604083; gene.
DR MIM; 618425; phenotype.
DR neXtProt; NX_P52746; -.
DR OpenTargets; ENSG00000115568; -.
DR PharmGKB; PA37514; -.
DR VEuPathDB; HostDB:ENSG00000115568; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163074; -.
DR HOGENOM; CLU_001774_0_0_1; -.
DR InParanoid; P52746; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P52746; -.
DR TreeFam; TF327469; -.
DR PathwayCommons; P52746; -.
DR SignaLink; P52746; -.
DR BioGRID-ORCS; 7701; 10 hits in 1098 CRISPR screens.
DR ChiTaRS; ZNF142; human.
DR GenomeRNAi; 7701; -.
DR Pharos; P52746; Tdark.
DR PRO; PR:P52746; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; P52746; protein.
DR Bgee; ENSG00000115568; Expressed in cortical plate and 159 other tissues.
DR ExpressionAtlas; P52746; baseline and differential.
DR Genevisible; P52746; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 36.
DR SUPFAM; SSF57667; SSF57667; 12.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 17.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 18.
PE 1: Evidence at protein level;
KW Disease variant; DNA-binding; Intellectual disability; Isopeptide bond;
KW Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..1687
FT /note="Zinc finger protein 142"
FT /id="PRO_0000047425"
FT ZN_FING 163..185
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 219..242
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 253..275
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 286..311
FT /note="C2H2-type 4; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 316..340
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 343..366
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 372..395
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 401..423
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 429..451
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 457..479
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 485..507
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 512..536
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 544..567
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 573..596
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1135..1158
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1171..1194
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1200..1222
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1228..1251
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1257..1280
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1286..1309
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1328..1351
FT /note="C2H2-type 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1354..1377
FT /note="C2H2-type 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1380..1403
FT /note="C2H2-type 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1424..1446
FT /note="C2H2-type 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1452..1474
FT /note="C2H2-type 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1480..1502
FT /note="C2H2-type 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1508..1530
FT /note="C2H2-type 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1536..1559
FT /note="C2H2-type 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1565..1587
FT /note="C2H2-type 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1593..1615
FT /note="C2H2-type 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1621..1643
FT /note="C2H2-type 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 613..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 704..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 897..935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 947..1014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1052..1092
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1638..1687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1062..1092
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 154
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT CROSSLNK 594
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:25218447"
FT CROSSLNK 1193
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 1242
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 1591
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VARIANT 751
FT /note="S -> G (in dbSNP:rs3770214)"
FT /evidence="ECO:0000269|PubMed:9039502"
FT /id="VAR_047230"
FT VARIANT 956
FT /note="L -> H (in dbSNP:rs3770213)"
FT /id="VAR_047231"
FT VARIANT 1059..1687
FT /note="Missing (in NEDISHM)"
FT /evidence="ECO:0000269|PubMed:31036918"
FT /id="VAR_082094"
FT VARIANT 1233
FT /note="C -> F (in NEDISHM; dbSNP:rs1275959058)"
FT /evidence="ECO:0000269|PubMed:31036918"
FT /id="VAR_082095"
FT VARIANT 1313
FT /note="A -> T (in dbSNP:rs3821033)"
FT /id="VAR_047232"
FT VARIANT 1395..1687
FT /note="Missing (in NEDISHM)"
FT /evidence="ECO:0000269|PubMed:31036918"
FT /id="VAR_082096"
FT VARIANT 1500
FT /note="R -> T (in NEDISHM)"
FT /evidence="ECO:0000269|PubMed:31036918"
FT /id="VAR_082097"
FT CONFLICT 460..463
FT /note="TECG -> LKGS (in Ref. 2; AAC50265)"
FT /evidence="ECO:0000305"
FT CONFLICT 541
FT /note="A -> S (in Ref. 1; BAA13242)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1687 AA; 187880 MW; 91143EAF2481B6B3 CRC64;
MTDPLLDSQP ASSTGEMDGL CPELLLIPPP LSNRGILGPV QSPCPSRDPA PIPTEPGCLL
VEATATEEGP GNMEIIVETV AGTLTPGAPG ETPAPKLPPG EREPSQEAGT PLPGQETAEE
ENVEKEEKSD TQKDSQKAVD KGQGAQRLEG DVVSGTESLF KTHMCPECKR CFKKRTHLVE
HLHLHFPDPS LQCPNCQKFF TSKSKLKTHL LRELGEKAHH CPLCHYSAVE RNALNRHMAS
MHEDISNFYS DTYACPVCRE EFRLSQALKE HLKSHTAAAA AEPLPLRCFQ EGCSYAAPDR
KAFIKHLKET HGVRAVECRH HSCPMLFATA EAMEAHHKSH YAFHCPHCDF ACSNKHLFRK
HKKQGHPGSE ELRCTFCPFA TFNPVAYQDH VGKMHAHEKI HQCPECNFAT AHKRVLIRHM
LLHTGEKPHK CELCDFTCRD VSYLSKHMLT HSNTKDYMCT ECGYVTKWKH YLRVHMRKHA
GDLRYQCNQC SYRCHRADQL SSHKLRHQGK SLMCEVCAFA CKRKYELQKH MASQHHPGTP
APLYPCHYCS YQSRHKQAVL SHENCKHTRL REFHCALCDY RTFSNTTLLF HKRKAHGYVP
GDQAWQLRYA SQEPEGAMQG PTPPPDSEPS NQLSARPEGP GHEPGTVVDP SLDQALPEMS
EEVNTGRQEG SEAPHGGDLG GSPSPAEVEE GSCTLHLEAL GVELESVTEP PLEEVTETAP
MEFRPLGLEG PDGLEGPELS SFEGIGTSDL SAEENPLLEK PVSEPSTNPP SLEEAPNNWV
GTFKTTPPAE TAPLPPLPES ESLLKALRRQ DKEQAEALVL EGRVQMVVIQ GEGRAFRCPH
CPFITRREKA LNLHSRTGCQ GRREPLLCPE CGASFKQQRG LSTHLLKKCP VLLRKNKGLP
RPDSPIPLQP VLPGTQASED TESGKPPPAS QEAELLLPKD APLELPREPE ETEEPLATVS
GSPVPPAGNS LPTEAPKKHC FDPVPPAGNS SPTEAPKKHH LDPVPPAGNS SPTEALKKHR
FEQGKFHCNS CPFLCSRLSS ITSHVAEGCR GGRGGGGKRG TPQTQPDVSP LSNGDSAPPK
NGSTESSSGD GDTVLVQKQK GARFSCPTCP FSCQQERALR THQIRGCPLE ESGELHCSLC
PFTAPAATAL RLHQKRRHPT AAPARGPRPH LQCGDCGFTC KQSRCMQQHR RLKHEGVKPH
QCPFCDFSTT RRYRLEAHQS RHTGIGRIPC SSCPQTFGTN SKLRLHRLRV HDKTPTHFCP
LCDYSGYLRH DITRHVNSCH QGTPAFACSQ CEAQFSSETA LKQHALRRHP EPAQPAPGSP
AETTEGPLHC SRCGLLCPSP ASLRGHTRKQ HPRLECGACQ EAFPSRLALD EHRRQQHFSH
RCQLCDFAAR ERVGLVKHYL EQHEETSAAV AASDGDGDAG QPPLHCPFCD FTCRHQLVLD
HHVKGHGGTR LYKCTDCAYS TKNRQKITWH SRIHTGEKPY HCHLCPYACA DPSRLKYHMR
IHKEERKYLC PECGYKCKWV NQLKYHMTKH TGLKPYQCPE CEYCTNRADA LRVHQETRHR
EARAFMCEQC GKAFKTRFLL RTHLRKHSEA KPYVCNVCHR AFRWAAGLRH HALTHTDRHP
FFCRLCNYKA KQKFQVVKHV RRHHPDQADP NQGVGKDPTT PTVHLHDVQL EDPSPPAPAA
PHTGPEG
