ZN142_MOUSE
ID ZN142_MOUSE Reviewed; 1843 AA.
AC G5E869; E9PY67; Q3V1C1; Q8BWJ0; Q8BWL4; Q8CHH6;
DT 18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Zinc finger protein 142 {ECO:0000305};
GN Name=Znf142 {ECO:0000250|UniProtKB:P52746};
GN Synonyms=Kiaa0236 {ECO:0000303|PubMed:12465718},
GN Zfp142 {ECO:0000312|MGI:MGI:1924514};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=12465718; DOI=10.1093/dnares/9.5.179;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: I.
RT The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 9:179-188(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Head, and Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=G5E869-1; Sequence=Displayed;
CC Name=2;
CC IsoId=G5E869-2; Sequence=VSP_060317;
CC Name=3;
CC IsoId=G5E869-3; Sequence=VSP_060316;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC41402.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB093218; BAC41402.1; ALT_INIT; mRNA.
DR EMBL; AK052201; BAC34881.1; -; mRNA.
DR EMBL; AK052359; BAC34956.1; -; mRNA.
DR EMBL; AK132550; BAE21230.1; -; mRNA.
DR EMBL; AC117610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466548; EDL00334.1; -; Genomic_DNA.
DR CCDS; CCDS35618.1; -. [G5E869-2]
DR CCDS; CCDS78619.1; -. [G5E869-1]
DR RefSeq; NP_001297597.1; NM_001310668.1. [G5E869-1]
DR RefSeq; NP_084164.1; NM_029888.3. [G5E869-2]
DR RefSeq; XP_006496381.1; XM_006496318.2. [G5E869-1]
DR RefSeq; XP_006496382.1; XM_006496319.2. [G5E869-1]
DR RefSeq; XP_006496384.1; XM_006496321.2.
DR AlphaFoldDB; G5E869; -.
DR STRING; 10090.ENSMUSP00000109366; -.
DR iPTMnet; G5E869; -.
DR PhosphoSitePlus; G5E869; -.
DR jPOST; G5E869; -.
DR MaxQB; G5E869; -.
DR ProteomicsDB; 339071; -.
DR ProteomicsDB; 341149; -. [G5E869-1]
DR ProteomicsDB; 352915; -.
DR Antibodypedia; 56468; 26 antibodies from 10 providers.
DR Ensembl; ENSMUST00000027315; ENSMUSP00000027315; ENSMUSG00000026135. [G5E869-1]
DR Ensembl; ENSMUST00000066986; ENSMUSP00000065149; ENSMUSG00000026135. [G5E869-3]
DR Ensembl; ENSMUST00000113737; ENSMUSP00000109366; ENSMUSG00000026135. [G5E869-2]
DR GeneID; 77264; -.
DR KEGG; mmu:77264; -.
DR UCSC; uc007bmm.1; mouse.
DR UCSC; uc007bmn.1; mouse. [G5E869-1]
DR CTD; 77264; -.
DR MGI; MGI:1924514; Zfp142.
DR VEuPathDB; HostDB:ENSMUSG00000026135; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163074; -.
DR HOGENOM; CLU_001774_0_0_1; -.
DR InParanoid; G5E869; -.
DR OMA; LCEFRCR; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; G5E869; -.
DR TreeFam; TF327469; -.
DR BioGRID-ORCS; 77264; 3 hits in 58 CRISPR screens.
DR PRO; PR:G5E869; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; G5E869; protein.
DR Bgee; ENSMUSG00000026135; Expressed in animal zygote and 240 other tissues.
DR ExpressionAtlas; G5E869; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 41.
DR SUPFAM; SSF57667; SSF57667; 12.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 20.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 21.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus;
KW Phosphoprotein; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..1843
FT /note="Zinc finger protein 142"
FT /id="PRO_0000447987"
FT ZN_FING 103..127
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 164..186
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 363..385
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 391..413
FT /note="C2H2-type 4; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 453..475
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 543..566
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 601..623
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 629..651
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 657..679
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 685..707
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 744..767
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1331..1354
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1388..1411
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1446..1469
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1514..1537
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1608..1630
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1636..1658
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1664..1686
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1692..1715
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1721..1743
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1749..1771
FT /note="C2H2-type 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 294..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 819..888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1103..1177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1795..1843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 860..874
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1151..1167
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1828..1843
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 354
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P52746"
FT CROSSLNK 794
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P52746"
FT CROSSLNK 1353
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P52746"
FT CROSSLNK 1402
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P52746"
FT CROSSLNK 1747
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P52746"
FT VAR_SEQ 94..294
FT /note="Missing (in isoform 3)"
FT /id="VSP_060316"
FT VAR_SEQ 94..196
FT /note="Missing (in isoform 2)"
FT /id="VSP_060317"
FT CONFLICT 1764
FT /note="L -> M (in Ref. 2; BAC34881)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1843 AA; 206230 MW; 3A35EF70A8E226B6 CRC64;
MTDPVLASQL ANGTGEMDGL CSELLLIPPP LSNHGILGPV QNTCASGELA PLPADPGCLL
VEATATEEGP GNMEIIVEAV TGTLSPGAPE ETSGVLVKVV EVYFCERCEQ SFAEPTLLSV
HQCTETHIQA VQDLSSPPCS VELPPSNLAL RGPLQDPSLP DSPLPCPVCR QEFVQPQALK
SHFKIHRVTP NMFSCPESGC VFSAEDRKGL QNHLRQTHKA VPVPCSFRGC SLLFGSQQGM
ELHRQAHYPF HCSHCSFMGS NVKLFRQHQR SHGASARGEL SAAVQGLPSQ ELLPAAKLPP
GHREPSEEAS TPLPGQESAE EEDAEEEESV TQKDSQKVMD KSQGAQQLEG HVGSGTESLF
KTHMCPECKR CFKKRTHLVE HLHLHFPDPS LQCPNCQKFF TSKSKLKTHL LRELGEKAHR
CPLCHYSAVE RNALNRHMAS MHEDISNFYS DTYACPVCRE EFRLSQALKE HLKSHTAAAA
AEPLPLHCFQ EGCTYVAPDR KAFLKHLKEI HGVRAVECRH HSCPMLFATA EAMEAHHKSH
YAFHCPHCDF ACSNKHLFRK HKKQGHPGSE ELRCTFCPFA TFNPVAYQDH VGKMHAYEKI
HQCSECNFAT AHKRVLIRHM LLHTGEKPHK CELCDFTCRD VSYLSKHMLT HSNTKDYMCT
ECGYVTKWKH YLSVHMRKHA GDLRYQCNQC SYRCHRADQL SSHKLRHQGK SLMCEVCAFA
CKRKYELQKH MASQHHPGTP APLYPCRYCS YQSRHKQALL SHENCKHTHL REFHCALCDY
RTFSNTTLFF HKRKVHGYMP GDQVWQFCNA SQELEGARQC LAPPSDSGPS SQLSAQPERE
DREHEIVANS NMDQALPETN EEASPKRQDG IEAPQEDDQV DSPSLGEVEE GGCTLHLEAL
RVELEPETEP LPLEELTETA TVEFRPLDPS GPLGTERPGG LEEPALSSFD SIETPALVAE
EEPVVEKLAS EPPRNPLISE EAPNTFKAAL TAETVPLPPF PESESLLKAM RRQDKEQAEA
LVLEGRVQMV VIQGEGRAFR CPHCPFITRR EKALTLHSKS GCQGRREPLL CPECGASFKQ
QRGLSTHMMK KCPVLLKKNK ALPKPVSPTL HPQLPDNQAS QDAESRKPPP LPSKVELLLP
KDAPSDLPGG PGVEEPLPTP SDFPTSPPEN SLPTGTSEKF HFEQGKFHCS SCTFLCSRLS
SITSHVTEGC RGGRGQKRKR GRPQTHAVVL PLNNGDSTLL NTGSTESSPS DGDTAVVQKQ
KGALFSCPTC PFSCQQERTL RTHQTQGCPL KSGDLHCGLC PFTAPAAAAL RLHQKRRHPT
ASPASGPRPL LQCGDCGFTC KQSRCLQQHR RLKHEGVKPH QCPFCDFSTT RRYRLEAHQS
RHTGVGRIPC SSCPQTFGTN SKLRLHQLRV HDKTPTHFCP LCDYSGYLRH DITRHVNSCH
QGTPSFSCTQ CEAQFSSETA LKQHALRRHP EPTPPSSGCP VEVTEGPLHC SHCGLLCPSP
ASLRGHTRKQ HPRLECGACQ ESFPNRPALD EHRRQHHFSH RCQLCSFAAR ERVGLVKHYL
EQHEESSTAP SDGDAGQPSL CCPFCDFACR HQLVLDHHVK GHGGTRLYKC TDCAYSTKNR
QKITWHSRIH TGEKPYHCHL CAYACADPSR LKYHMRIHKE ERKYLCPECG YKCKWVNQLK
YHMTKHTGLK PYQCPECEYC TNRADALRVH RETRHREARA FMCEQCGKAF KTRFLLRTHL
RKHSEAKPYV CNVCHRAFRW AAGLRHHALT HTDRHPFFCR LCSYKAKQKF QVVKHVRRHH
PDQADPNQGV GKDPTTPTVH LHDVKLEDPS PPAPPAPSTG PEG
