ZN143_DANRE
ID ZN143_DANRE Reviewed; 623 AA.
AC Q1LYE3; A0AUQ7; Q6VQB1;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Zinc finger protein 143;
DE AltName: Full=Selenocysteine tRNA gene transcription-activating factor;
GN Name=znf143; Synonyms=staf; ORFNames=si:dkey-8l13.2, zgc:66276;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15087134; DOI=10.1016/j.gene.2004.01.021;
RA Myslinski E., Krol A., Carbon P.;
RT "Characterization of snRNA and snRNA-type genes in the pufferfish Fugu
RT rubripes.";
RL Gene 330:149-158(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional activator. Activates the gene for
CC selenocysteine tRNA (tRNAsec). Binds to the activator element (AE)
CC motif of the selenocysteine tRNA gene promoter (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAK11243.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY331976; AAQ94617.1; -; mRNA.
DR EMBL; BX005395; CAK11243.1; ALT_INIT; Genomic_DNA.
DR EMBL; BC124735; AAI24736.1; -; mRNA.
DR RefSeq; XP_005159129.1; XM_005159072.3.
DR RefSeq; XP_009291820.1; XM_009293545.2.
DR RefSeq; XP_017207398.1; XM_017351909.1.
DR AlphaFoldDB; Q1LYE3; -.
DR SMR; Q1LYE3; -.
DR STRING; 7955.ENSDARP00000107422; -.
DR PaxDb; Q1LYE3; -.
DR Ensembl; ENSDART00000022640; ENSDARP00000009795; ENSDARG00000041581.
DR Ensembl; ENSDART00000187799; ENSDARP00000148129; ENSDARG00000112408.
DR Ensembl; ENSDART00000190974; ENSDARP00000154229; ENSDARG00000111018.
DR GeneID; 393954; -.
DR CTD; 393954; -.
DR ZFIN; ZDB-GENE-040426-1586; znf143b.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000157584; -.
DR InParanoid; Q1LYE3; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q1LYE3; -.
DR PRO; PR:Q1LYE3; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 18.
DR Bgee; ENSDARG00000041581; Expressed in tail and 23 other tissues.
DR ExpressionAtlas; Q1LYE3; baseline.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..623
FT /note="Zinc finger protein 143"
FT /id="PRO_0000370718"
FT ZN_FING 230..254
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 260..284
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 290..314
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 320..344
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 350..374
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 380..404
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 410..433
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 121
FT /note="I -> T (in Ref. 3; AAI24736)"
FT /evidence="ECO:0000305"
FT CONFLICT 593
FT /note="I -> K (in Ref. 1; AAQ94617)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 623 AA; 67929 MW; E2CCDB54F158D521 CRC64;
MLLAQVNRDT QGMEFQSVDG DPQQVTLCLT EAVTVADDNI DGMDTVSLQA VTLVDGSTAY
IQHSPKVSLT ENKIMEGQVI QLEDGSAAYV QHLPMSKTGG EGLRLEDGQA VQLEDGTTAY
IHAPKETYDQ GGLQAVQLED GTTAYIQHMP QSNTILAIQA DGTVADLQTE GTIDAETISV
LEQYSTKMEA TECGTGLIGR GDSDGVHMQI VLQGQDCRSP RIQHVGEKAF RCEHEGCGKL
YTTAHHLKVH ERSHTGDKPY ICDHLGCGKK FATGYGLKSH VRTHTGEKPY RCQELNCLKS
FKTSGDLQKH TRTHTGEKPF KCPFEGCGRS FTTSNIRKVH IRTHTGERPY YCAEPNCGRA
FASATNYKNH MRIHTGEKPY VCTVPGCDKR FTEYSSLYKH HVVHTPCKPY NCNHCGKTYK
QISTLAMHKR TAHNDTEPIE EEQEGYFEPP AEAIDDPGLM YTPSVVDDDS GSEQVSGSEI
MGQHHVALIS QDGTQQVLSQ ADMQAMGGTI TMVTQEGTTI TIPAHEAMLS SGGAHSVTMV
SADGTEGQVA IVTPDLAAYQ TEEGELIQDQ EQHEVSTSPH PVTLLATSNG THIAVQLSDH
PSLEEAIRIA SRIQQGETPG MDD
