ID   ZN143_XENTR             Reviewed;         567 AA.
AC   Q58DZ6;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Zinc finger protein 143;
DE   AltName: Full=Selenocysteine tRNA gene transcription-activating factor;
GN   Name=znf143; Synonyms=staf;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional activator. Activates the gene for
CC       selenocysteine tRNA (tRNAsec). Binds to the activator element (AE)
CC       motif of the selenocysteine tRNA gene promoter (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH92134.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC092134; AAH92134.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001025654.1; NM_001030483.1.
DR   AlphaFoldDB; Q58DZ6; -.
DR   SMR; Q58DZ6; -.
DR   PRIDE; Q58DZ6; -.
DR   DNASU; 595042; -.
DR   GeneID; 595042; -.
DR   KEGG; xtr:595042; -.
DR   CTD; 7702; -.
DR   Xenbase; XB-GENE-1012504; znf143.
DR   HOGENOM; CLU_027168_0_0_1; -.
DR   InParanoid; Q58DZ6; -.
DR   OrthoDB; 1318335at2759; -.
DR   Reactome; R-XTR-6807505; RNA polymerase II transcribes snRNA genes.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000024199; Expressed in 2-cell stage embryo and 13 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 6.
DR   SMART; SM00355; ZnF_C2H2; 7.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..567
FT                   /note="Zinc finger protein 143"
FT                   /id="PRO_0000370720"
FT   ZN_FING         230..254
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         260..284
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         290..314
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         320..344
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         350..374
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         380..404
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         410..433
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          506..525
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   567 AA;  61601 MW;  863608551D7AC4A2 CRC64;
     MLLAQINRDS QAMAEFPGGG GEAQHVTLCL TEAVADGESM DTMEGMSLQA VTLADGSTAY
     IQHNTKDGKL MEGQVIQLED GSAAYVQHVP KGDDLSLEDG QAVQLEDGTT AYIHHSSKDS
     YDQSSVQAVQ LEDGTTAYIH HAVQVPQSDT ILAIQADGTV AGLHTGEASI DPDTISALEQ
     YAAKVSIEGG EGAGSNALIN ESESEKKMQI VLSHGSRIPA KPPQTNEKAF RCDYEGCGKL
     YTTAHHLKVH ERSHTGDRPY QCDHGGCRKA FATGYGLKSH VRTHTGEKPY RCSEENCTKS
     FKTSGDLQKH VRTHTGERPF KCPFEGCGRS FTTSNIRKVH IRTHTGERPY YCSEPGCGRA
     FASATNYKNH VRIHTGEKPY VCTVPGCDKR FTEYSSLYKH HVVHTHSKPY NCNHCGKTYK
     QISTLAMHKR TAHNDTEPIE EEQESFFVPQ PPDEVIKGSQ ITYVTGVDGE DGIQTTQSGQ
     QLALIAQDGT SHVAIVAQDL SAFHTSATES GPQHSHNLGG SESRPVTLLA TSNGRQIAVQ
     IGEQQSLEEA IRIASRIQQG ESPGIED