ZN154_HUMAN
ID ZN154_HUMAN Reviewed; 437 AA.
AC Q13106; A7MCY3; Q8IVG7; Q8NAR0;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 3.
DT 03-AUG-2022, entry version 181.
DE RecName: Full=Zinc finger protein 154;
GN Name=ZNF154; Synonyms=KIAA2003;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-57.
RC TISSUE=Brain;
RA Nagase T., Kikuno R., Ohara O.;
RT "The nucleotide sequence of a long cDNA clone isolated from human.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-57.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 351-437.
RC TISSUE=Insulinoma;
RX PubMed=7557990; DOI=10.1006/geno.1995.1040;
RA Tommerup N., Vissing H.;
RT "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs
RT identify putative candidate genes for developmental and malignant
RT disorders.";
RL Genomics 27:259-264(1995).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC23100.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK092261; BAC03839.1; -; mRNA.
DR EMBL; AB095924; BAC23100.1; ALT_INIT; mRNA.
DR EMBL; BC152404; AAI52405.1; -; mRNA.
DR EMBL; BC152426; AAI52427.1; -; mRNA.
DR EMBL; BC152561; AAI52562.1; -; mRNA.
DR EMBL; U20648; AAC50257.1; -; mRNA.
DR CCDS; CCDS42639.1; -.
DR PIR; I38941; I38941.
DR RefSeq; NP_001078853.1; NM_001085384.2.
DR AlphaFoldDB; Q13106; -.
DR SMR; Q13106; -.
DR BioGRID; 113504; 34.
DR IntAct; Q13106; 1.
DR STRING; 9606.ENSP00000421258; -.
DR iPTMnet; Q13106; -.
DR PhosphoSitePlus; Q13106; -.
DR BioMuta; ZNF154; -.
DR DMDM; 143811477; -.
DR MassIVE; Q13106; -.
DR MaxQB; Q13106; -.
DR PaxDb; Q13106; -.
DR PeptideAtlas; Q13106; -.
DR PRIDE; Q13106; -.
DR ProteomicsDB; 59157; -.
DR Antibodypedia; 33286; 92 antibodies from 18 providers.
DR DNASU; 7710; -.
DR Ensembl; ENST00000451275.1; ENSP00000469633.1; ENSG00000179909.16.
DR Ensembl; ENST00000512439.6; ENSP00000421258.2; ENSG00000179909.16.
DR Ensembl; ENST00000684351.1; ENSP00000507206.1; ENSG00000179909.16.
DR GeneID; 7710; -.
DR KEGG; hsa:7710; -.
DR MANE-Select; ENST00000684351.1; ENSP00000507206.1; NM_001085384.3; NP_001078853.1.
DR UCSC; uc061dmm.1; human.
DR CTD; 7710; -.
DR DisGeNET; 7710; -.
DR GeneCards; ZNF154; -.
DR HGNC; HGNC:12939; ZNF154.
DR HPA; ENSG00000179909; Low tissue specificity.
DR MIM; 604085; gene.
DR neXtProt; NX_Q13106; -.
DR OpenTargets; ENSG00000179909; -.
DR PharmGKB; PA37523; -.
DR VEuPathDB; HostDB:ENSG00000179909; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000154734; -.
DR HOGENOM; CLU_002678_0_2_1; -.
DR InParanoid; Q13106; -.
DR OMA; REKCYMC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q13106; -.
DR TreeFam; TF339848; -.
DR PathwayCommons; Q13106; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q13106; -.
DR BioGRID-ORCS; 7710; 21 hits in 1090 CRISPR screens.
DR ChiTaRS; ZNF154; human.
DR GenomeRNAi; 7710; -.
DR Pharos; Q13106; Tbio.
DR PRO; PR:Q13106; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q13106; protein.
DR Bgee; ENSG00000179909; Expressed in cortical plate and 95 other tissues.
DR ExpressionAtlas; Q13106; baseline and differential.
DR Genevisible; Q13106; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 10.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..437
FT /note="Zinc finger protein 154"
FT /id="PRO_0000047430"
FT DOMAIN 14..88
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 89..111
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 133..155
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 161..183
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 189..211
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 217..239
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 245..267
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 273..295
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 301..323
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 329..351
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 357..379
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 385..407
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 413..435
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 110..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 57
FT /note="H -> R (in dbSNP:rs34282745)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT /id="VAR_060678"
FT VARIANT 122
FT /note="G -> V (in dbSNP:rs2074078)"
FT /id="VAR_052779"
FT VARIANT 182
FT /note="L -> V (in dbSNP:rs2188736)"
FT /id="VAR_052780"
FT VARIANT 384
FT /note="P -> L (in dbSNP:rs34746514)"
FT /id="VAR_052781"
FT CONFLICT 3
FT /note="A -> V (in Ref. 1; BAC03839)"
FT /evidence="ECO:0000305"
FT CONFLICT 296
FT /note="S -> I (in Ref. 1; BAC03839)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 437 AA; 49865 MW; 37469112DC85BFEB CRC64;
MAAATLRTPT QGTVTFEDVA VHFSWEEWGL LDEAQRCLYR DVMLENLALL TSLDVHHQKQ
HLGEKHFRSN VGRALFVKTC TFHVSGEPST CREVGKDFLA KLGFLHQQAA HTGEQSNSKS
DGGAISHRGK THYNCGEHTK AFSGKHTLVQ QQRTLTTERC YICSECGKSF SKSYSLNDHW
RLHTGEKPYE CRECGKSFRQ SSSLIQHRRV HTAVRPHECD ECGKLFSNKS NLIKHRRVHT
GERPYECSEC GKSFSQRSAL LQHRGVHTGE RPYECSECGK FFTYHSSLIK HQKVHSGSRP
YECSECGKSF SQNSSLIEHH RVHTGERPYK CSECGKSFSQ RSALLQHRGV HTGERPYECS
ECGKFFPYSS SLRKHQRVHT GSRPYECSEC GKSFTQNSGL IKHRRVHTGE KPYECTECGK
SFSHNSSLIK HQRIHSR
