ZN155_HUMAN
ID ZN155_HUMAN Reviewed; 538 AA.
AC Q12901; A2BDE6; B2RB63; B4DM95; J3KQ08; Q6AZZ8; Q9UIE1; Q9UK14;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 23-MAR-2010, sequence version 4.
DT 03-AUG-2022, entry version 189.
DE RecName: Full=Zinc finger protein 155;
GN Name=ZNF155;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS PHE-157 AND HIS-251.
RX PubMed=12743021; DOI=10.1101/gr.963903;
RA Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.;
RT "Differential expansion of zinc-finger transcription factor loci in
RT homologous human and mouse gene clusters.";
RL Genome Res. 13:1097-1110(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS PHE-157 AND HIS-251.
RA Kodoyianni V., Ge Y., Westphall M.S., Berggren W.T., Severin J.,
RA Krummel G.K., Gordon L., Shannon M., Olsen A.S., Smith L.M.;
RT "Sequence analysis of a 1Mb region in 19q13.2 containing a zinc finger gene
RT cluster.";
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS
RP PHE-157; LEU-231 AND HIS-251.
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS PHE-157
RP AND HIS-251.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 326-464 (ISOFORM 1/2).
RC TISSUE=Insulinoma;
RX PubMed=7557990; DOI=10.1006/geno.1995.1040;
RA Tommerup N., Vissing H.;
RT "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs
RT identify putative candidate genes for developmental and malignant
RT disorders.";
RL Genomics 27:259-264(1995).
RN [7]
RP VARIANT [LARGE SCALE ANALYSIS] ARG-474.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q12901; O95273: CCNDBP1; NbExp=3; IntAct=EBI-10747670, EBI-748961;
CC Q12901; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-10747670, EBI-5916454;
CC Q12901; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-10747670, EBI-12012928;
CC Q12901; Q99750: MDFI; NbExp=3; IntAct=EBI-10747670, EBI-724076;
CC Q12901-2; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10227379, EBI-10172290;
CC Q12901-2; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-10227379, EBI-10172052;
CC Q12901-2; Q99750: MDFI; NbExp=3; IntAct=EBI-10227379, EBI-724076;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q12901-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q12901-2; Sequence=VSP_047207;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AF187986; AAF04102.1; -; mRNA.
DR EMBL; AC018725; AAF18684.1; -; Genomic_DNA.
DR EMBL; AK297360; BAG59807.1; -; mRNA.
DR EMBL; AK314510; BAG37110.1; -; mRNA.
DR EMBL; AC006213; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC075050; AAH75050.1; -; mRNA.
DR EMBL; BC075051; AAH75051.1; -; mRNA.
DR EMBL; BC126377; AAI26378.1; -; mRNA.
DR EMBL; BC130381; AAI30382.1; -; mRNA.
DR EMBL; U09852; AAC50268.1; -; mRNA.
DR CCDS; CCDS12634.1; -. [Q12901-1]
DR CCDS; CCDS58668.1; -. [Q12901-2]
DR PIR; I38620; I38620.
DR RefSeq; NP_001247415.1; NM_001260486.1. [Q12901-1]
DR RefSeq; NP_001247416.1; NM_001260487.1. [Q12901-1]
DR RefSeq; NP_001247417.1; NM_001260488.1. [Q12901-2]
DR RefSeq; NP_003436.3; NM_003445.3. [Q12901-1]
DR RefSeq; NP_932355.2; NM_198089.2. [Q12901-1]
DR RefSeq; XP_005259272.1; XM_005259215.3. [Q12901-1]
DR RefSeq; XP_011525580.1; XM_011527278.2. [Q12901-2]
DR RefSeq; XP_011525581.1; XM_011527279.2. [Q12901-2]
DR RefSeq; XP_016882737.1; XM_017027248.1. [Q12901-2]
DR AlphaFoldDB; Q12901; -.
DR SMR; Q12901; -.
DR BioGRID; 113505; 8.
DR IntAct; Q12901; 7.
DR STRING; 9606.ENSP00000385163; -.
DR iPTMnet; Q12901; -.
DR PhosphoSitePlus; Q12901; -.
DR BioMuta; ZNF155; -.
DR DMDM; 292495098; -.
DR jPOST; Q12901; -.
DR MassIVE; Q12901; -.
DR PaxDb; Q12901; -.
DR PeptideAtlas; Q12901; -.
DR PRIDE; Q12901; -.
DR ProteomicsDB; 59010; -. [Q12901-1]
DR Antibodypedia; 841; 122 antibodies from 19 providers.
DR DNASU; 7711; -.
DR Ensembl; ENST00000270014.7; ENSP00000270014.1; ENSG00000204920.11. [Q12901-1]
DR Ensembl; ENST00000407951.6; ENSP00000385163.2; ENSG00000204920.11. [Q12901-2]
DR Ensembl; ENST00000590615.5; ENSP00000465691.1; ENSG00000204920.11. [Q12901-1]
DR Ensembl; ENST00000611002.4; ENSP00000481677.1; ENSG00000204920.11. [Q12901-1]
DR GeneID; 7711; -.
DR KEGG; hsa:7711; -.
DR MANE-Select; ENST00000270014.7; ENSP00000270014.1; NM_198089.3; NP_932355.3.
DR UCSC; uc002oxy.3; human. [Q12901-1]
DR CTD; 7711; -.
DR DisGeNET; 7711; -.
DR GeneCards; ZNF155; -.
DR HGNC; HGNC:12940; ZNF155.
DR HPA; ENSG00000204920; Low tissue specificity.
DR MIM; 604086; gene.
DR neXtProt; NX_Q12901; -.
DR PharmGKB; PA37524; -.
DR VEuPathDB; HostDB:ENSG00000204920; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163825; -.
DR HOGENOM; CLU_002678_31_5_1; -.
DR InParanoid; Q12901; -.
DR OMA; WVMETAT; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q12901; -.
DR TreeFam; TF341885; -.
DR PathwayCommons; Q12901; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q12901; -.
DR BioGRID-ORCS; 7711; 22 hits in 1093 CRISPR screens.
DR ChiTaRS; ZNF155; human.
DR GenomeRNAi; 7711; -.
DR Pharos; Q12901; Tdark.
DR PRO; PR:Q12901; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q12901; protein.
DR Bgee; ENSG00000204920; Expressed in secondary oocyte and 126 other tissues.
DR ExpressionAtlas; Q12901; baseline and differential.
DR Genevisible; Q12901; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..538
FT /note="Zinc finger protein 155"
FT /id="PRO_0000047431"
FT DOMAIN 8..78
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 176..198
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 204..226
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 232..254
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 260..282
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 288..310
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 316..338
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 344..366
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 372..394
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 400..422
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 428..450
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 456..478
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 484..506
FT /note="C2H2-type 12; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..5
FT /note="MTTFK -> MIKRSKVLVFCSKIME (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_047207"
FT VARIANT 157
FT /note="I -> F (in dbSNP:rs398235)"
FT /evidence="ECO:0000269|PubMed:12743021,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334,
FT ECO:0000269|Ref.2"
FT /id="VAR_060272"
FT VARIANT 231
FT /note="P -> L (in dbSNP:rs58537897)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_069362"
FT VARIANT 251
FT /note="R -> H (in dbSNP:rs448921)"
FT /evidence="ECO:0000269|PubMed:12743021,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334,
FT ECO:0000269|Ref.2"
FT /id="VAR_060273"
FT VARIANT 379
FT /note="K -> R (in dbSNP:rs2302411)"
FT /id="VAR_057399"
FT VARIANT 474
FT /note="H -> R (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs1345352474)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035571"
FT CONFLICT 169
FT /note="L -> S (in Ref. 1; AAF04102)"
FT /evidence="ECO:0000305"
FT CONFLICT 322
FT /note="D -> G (in Ref. 3; BAG59807)"
FT /evidence="ECO:0000305"
FT CONFLICT 326
FT /note="H -> K (in Ref. 6; AAC50268)"
FT /evidence="ECO:0000305"
FT CONFLICT 351
FT /note="K -> T (in Ref. 3; BAG59807)"
FT /evidence="ECO:0000305"
FT CONFLICT 427
FT /note="P -> S (in Ref. 3; BAG59807)"
FT /evidence="ECO:0000305"
FT CONFLICT 463..464
FT /note="KN -> RT (in Ref. 6; AAC50268)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 538 AA; 62081 MW; 3F552DC6A0D84352 CRC64;
MTTFKEAVTF KDVAVVFTEE ELGLLDPAQR KLYRDVMLEN FRNLLSVGHQ PFHQDTCHFL
REEKFWMMGT ATQREGNSGG KIQTELESVP EAGAHEEWSC QQIWEQIAKD LTRSQDSIIN
NSQFFENGDV PSQVEAGLPT IHTGQKPSQG GKCKQSISDV PIFDLPQQLY SEEKSYTCDE
CGKSICYISA LHVHQRVHVG EKLFMCDVCG KEFSQSSHLQ THQRVHTGEK PFKCEQCGKG
FSRRSALNVH RKLHTGEKPY ICEACGKAFI HDSQLKEHKR IHTGEKPFKC DICGKTFYFR
SRLKSHSMVH TGEKPFRCDT CDKSFHQRSA LNRHCMVHTG EKPYRCEQCG KGFIGRLDFY
KHQVVHTGEK PYNCKECGKS FRWSSCLLNH QRVHSGEKSF KCEECGKGFY TNSQLSSHQR
SHSGEKPYKC EECGKGYVTK FNLDLHQRVH TGERPYNCKE CGKNFSRASS ILNHKRLHCQ
KKPFKCEDCG KRLVHRTYRK DQPRDYSGEN PSKCEDCGRR YKRRLNLDIL LSLFLNDT
