ZN157_HUMAN
ID ZN157_HUMAN Reviewed; 506 AA.
AC P51786; Q96LE9;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2005, sequence version 2.
DT 03-AUG-2022, entry version 189.
DE RecName: Full=Zinc finger protein 157;
DE AltName: Full=Zinc finger protein HZF22;
GN Name=ZNF157;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8586441; DOI=10.1006/geno.1995.0031;
RA Derry J.M.J., Jess U., Francke U.;
RT "Cloning and characterization of a novel zinc finger gene in Xp11.2.";
RL Genomics 30:361-365(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Fetal brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U28687; AAA97578.1; -; mRNA.
DR EMBL; AL590223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL591503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC075003; AAH75003.1; -; mRNA.
DR CCDS; CCDS14278.1; -.
DR RefSeq; NP_003437.2; NM_003446.3.
DR AlphaFoldDB; P51786; -.
DR SMR; P51786; -.
DR BioGRID; 113506; 8.
DR IntAct; P51786; 2.
DR STRING; 9606.ENSP00000366273; -.
DR iPTMnet; P51786; -.
DR PhosphoSitePlus; P51786; -.
DR BioMuta; ZNF157; -.
DR DMDM; 62299056; -.
DR MassIVE; P51786; -.
DR MaxQB; P51786; -.
DR PaxDb; P51786; -.
DR PeptideAtlas; P51786; -.
DR PRIDE; P51786; -.
DR ProteomicsDB; 56382; -.
DR Antibodypedia; 523; 67 antibodies from 22 providers.
DR DNASU; 7712; -.
DR Ensembl; ENST00000377073.4; ENSP00000366273.4; ENSG00000147117.8.
DR GeneID; 7712; -.
DR KEGG; hsa:7712; -.
DR MANE-Select; ENST00000377073.4; ENSP00000366273.4; NM_003446.4; NP_003437.2.
DR UCSC; uc004dhr.2; human.
DR CTD; 7712; -.
DR DisGeNET; 7712; -.
DR GeneCards; ZNF157; -.
DR HGNC; HGNC:12942; ZNF157.
DR HPA; ENSG00000147117; Tissue enhanced (brain).
DR MIM; 300024; gene.
DR neXtProt; NX_P51786; -.
DR OpenTargets; ENSG00000147117; -.
DR PharmGKB; PA37525; -.
DR VEuPathDB; HostDB:ENSG00000147117; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162890; -.
DR HOGENOM; CLU_002678_44_3_1; -.
DR InParanoid; P51786; -.
DR OMA; KSLCQHQ; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P51786; -.
DR TreeFam; TF337898; -.
DR PathwayCommons; P51786; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; P51786; -.
DR BioGRID-ORCS; 7712; 9 hits in 723 CRISPR screens.
DR ChiTaRS; ZNF157; human.
DR GenomeRNAi; 7712; -.
DR Pharos; P51786; Tdark.
DR PRO; PR:P51786; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; P51786; protein.
DR Bgee; ENSG00000147117; Expressed in cortical plate and 63 other tissues.
DR Genevisible; P51786; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 10.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..506
FT /note="Zinc finger protein 157"
FT /id="PRO_0000047432"
FT DOMAIN 27..98
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 162..184
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 190..212
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 218..240
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 246..268
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 274..296
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 302..324
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 330..352
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 358..380
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 386..408
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 414..436
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 442..464
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 470..492
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 165
FT /note="H -> N (in Ref. 1; AAA97578)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 506 AA; 58291 MW; 59E1403E7F0CF944 CRC64;
MPANGTSPQR FPALIPGEPG RSFEGSVSFE DVAVDFTRQE WHRLDPAQRT MHKDVMLETY
SNLASVGLCV AKPEMIFKLE RGEELWILEE ESSGHGYSGS LSLLCGNGSV GDNALRHDND
LLHHQKIQTL DQNVEYNGCR KAFHEKTGFV RRKRTPRGDK NFECHECGKA YCRKSNLVEH
LRIHTGERPY ECGECAKTFS ARSYLIAHQK THTGERPFEC NECGKSFGRK SQLILHTRTH
TGERPYECTE CGKTFSEKAT LTIHQRTHTG EKPYECSECG KTFRVKISLT QHHRTHTGEK
PYECGECGKN FRAKKSLNQH QRIHTGEKPY ECGECGKFFR MKMTLNNHQR THTGEKPYQC
NECGKSFRVH SSLGIHQRIH TGEKPYECNE CGNAFYVKAR LIEHQRMHSG EKPYECSECG
KIFSMKKSLC QHRRTHTGEK PYECSECGNA FYVKVRLIEH QRIHTGERPF ECQECGKAFC
RKAHLTEHQR THIGWSWRCT MKKASH
