ZN160_HUMAN
ID ZN160_HUMAN Reviewed; 818 AA.
AC Q9HCG1; Q14589; Q504Q8; Q96JC5; Q9BVY9; Q9H7N6;
DT 21-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 183.
DE RecName: Full=Zinc finger protein 160;
DE AltName: Full=Zinc finger protein HZF5;
DE AltName: Full=Zinc finger protein Kr18;
DE Short=HKr18;
GN Name=ZNF160; Synonyms=KIAA1611;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Lymph, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-556 (ISOFORM 1), TISSUE SPECIFICITY, AND
RP VARIANT ARG-82.
RC TISSUE=Testis;
RX PubMed=11410164; DOI=10.1089/104454901750232472;
RA Mark C., Looman C., Abrink M., Hellman L.;
RT "Molecular cloning and preliminary functional analysis of two novel human
RT KRAB zinc finger proteins, HKr18 and HKr19.";
RL DNA Cell Biol. 20:275-286(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-818 (ISOFORM 1), AND VARIANT
RP ARG-82.
RC TISSUE=Brain;
RX PubMed=10997877; DOI=10.1093/dnares/7.4.271;
RA Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVIII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:273-281(2000).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 114-818 (ISOFORM 1).
RC TISSUE=Spleen;
RX PubMed=11214971; DOI=10.1093/dnares/7.6.357;
RA Hattori A., Okumura K., Nagase T., Kikuno R., Hirosawa M., Ohara O.;
RT "Characterization of long cDNA clones from human adult spleen.";
RL DNA Res. 7:357-366(2000).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 685-818 (ISOFORM 1).
RX PubMed=7865130; DOI=10.1089/dna.1995.14.125;
RA Abrink M., Aveskogh M., Hellman L.;
RT "Isolation of cDNA clones for 42 different Kruppel-related zinc finger
RT proteins expressed in the human monoblast cell line U-937.";
RL DNA Cell Biol. 14:125-136(1995).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9HCG1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9HCG1-2; Sequence=VSP_055940, VSP_055941;
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:11410164}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA55528.1; Type=Miscellaneous discrepancy; Note=Dubious alternative splicing.; Evidence={ECO:0000305};
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DR EMBL; AC010328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471135; EAW72110.1; -; Genomic_DNA.
DR EMBL; BC000807; AAH00807.1; -; mRNA.
DR EMBL; BC094880; AAH94880.1; -; mRNA.
DR EMBL; AF277623; AAK61306.1; -; mRNA.
DR EMBL; AB046831; BAB13437.1; -; mRNA.
DR EMBL; AK024442; BAB15732.1; -; mRNA.
DR EMBL; X78928; CAA55528.1; ALT_SEQ; mRNA.
DR CCDS; CCDS12859.1; -. [Q9HCG1-1]
DR CCDS; CCDS82392.1; -. [Q9HCG1-2]
DR PIR; S47066; S47066.
DR RefSeq; NP_001096073.1; NM_001102603.1. [Q9HCG1-1]
DR RefSeq; NP_001309054.1; NM_001322125.1. [Q9HCG1-2]
DR RefSeq; NP_001309055.1; NM_001322126.1. [Q9HCG1-2]
DR RefSeq; NP_001309057.1; NM_001322128.1. [Q9HCG1-1]
DR RefSeq; NP_001309058.1; NM_001322129.1. [Q9HCG1-1]
DR RefSeq; NP_001309059.1; NM_001322130.1. [Q9HCG1-1]
DR RefSeq; NP_001309060.1; NM_001322131.1. [Q9HCG1-1]
DR RefSeq; NP_001309061.1; NM_001322132.1. [Q9HCG1-1]
DR RefSeq; NP_001309062.1; NM_001322133.1. [Q9HCG1-1]
DR RefSeq; NP_001309063.1; NM_001322134.1. [Q9HCG1-1]
DR RefSeq; NP_001309064.1; NM_001322135.1. [Q9HCG1-1]
DR RefSeq; NP_001309065.1; NM_001322136.1. [Q9HCG1-1]
DR RefSeq; NP_150630.2; NM_033288.3. [Q9HCG1-1]
DR RefSeq; NP_942596.1; NM_198893.2. [Q9HCG1-1]
DR RefSeq; XP_016882935.1; XM_017027446.1.
DR RefSeq; XP_016882937.1; XM_017027448.1. [Q9HCG1-2]
DR AlphaFoldDB; Q9HCG1; -.
DR SMR; Q9HCG1; -.
DR BioGRID; 124698; 6.
DR IntAct; Q9HCG1; 6.
DR STRING; 9606.ENSP00000406201; -.
DR iPTMnet; Q9HCG1; -.
DR PhosphoSitePlus; Q9HCG1; -.
DR BioMuta; ZNF160; -.
DR DMDM; 296453072; -.
DR EPD; Q9HCG1; -.
DR jPOST; Q9HCG1; -.
DR MassIVE; Q9HCG1; -.
DR MaxQB; Q9HCG1; -.
DR PaxDb; Q9HCG1; -.
DR PeptideAtlas; Q9HCG1; -.
DR PRIDE; Q9HCG1; -.
DR ProteomicsDB; 79244; -.
DR ProteomicsDB; 81708; -. [Q9HCG1-1]
DR Antibodypedia; 19144; 79 antibodies from 18 providers.
DR DNASU; 90338; -.
DR Ensembl; ENST00000355147.9; ENSP00000347273.4; ENSG00000170949.18. [Q9HCG1-2]
DR Ensembl; ENST00000418871.5; ENSP00000409597.1; ENSG00000170949.18. [Q9HCG1-1]
DR Ensembl; ENST00000429604.5; ENSP00000406201.1; ENSG00000170949.18. [Q9HCG1-1]
DR Ensembl; ENST00000599056.5; ENSP00000470961.1; ENSG00000170949.18. [Q9HCG1-1]
DR Ensembl; ENST00000683776.1; ENSP00000507845.1; ENSG00000170949.18. [Q9HCG1-1]
DR GeneID; 90338; -.
DR KEGG; hsa:90338; -.
DR MANE-Select; ENST00000683776.1; ENSP00000507845.1; NM_001322131.2; NP_001309060.1.
DR UCSC; uc002qaq.5; human. [Q9HCG1-1]
DR CTD; 90338; -.
DR DisGeNET; 90338; -.
DR GeneCards; ZNF160; -.
DR HGNC; HGNC:12948; ZNF160.
DR HPA; ENSG00000170949; Low tissue specificity.
DR MIM; 600398; gene.
DR neXtProt; NX_Q9HCG1; -.
DR OpenTargets; ENSG00000170949; -.
DR PharmGKB; PA37531; -.
DR VEuPathDB; HostDB:ENSG00000170949; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162609; -.
DR HOGENOM; CLU_002678_17_1_1; -.
DR InParanoid; Q9HCG1; -.
DR OMA; QHDRRDI; -.
DR PhylomeDB; Q9HCG1; -.
DR TreeFam; TF341892; -.
DR PathwayCommons; Q9HCG1; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9HCG1; -.
DR BioGRID-ORCS; 90338; 9 hits in 1102 CRISPR screens.
DR ChiTaRS; ZNF160; human.
DR GeneWiki; ZNF160; -.
DR GenomeRNAi; 90338; -.
DR Pharos; Q9HCG1; Tbio.
DR PRO; PR:Q9HCG1; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9HCG1; protein.
DR Bgee; ENSG00000170949; Expressed in renal medulla and 213 other tissues.
DR ExpressionAtlas; Q9HCG1; baseline and differential.
DR Genevisible; Q9HCG1; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030097; P:hemopoiesis; NAS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 20.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 20.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 12.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 20.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 20.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..818
FT /note="Zinc finger protein 160"
FT /id="PRO_0000047433"
FT DOMAIN 8..79
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 257..279
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 285..307
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 313..335
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 341..363
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 369..391
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 397..419
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 425..447
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 453..475
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 481..503
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 509..531
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 537..559
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 565..587
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 593..615
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 621..643
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 649..671
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 677..699
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 705..727
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 733..755
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 761..783
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 789..811
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CROSSLNK 249
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q6ZN19"
FT VAR_SEQ 92..147
FT /note="IPPKCTIKDLLPKEKSSTEAVFHTVVLERHESPDIEDFSFKEPQKNVHDFEC
FT QWRD -> LLRRWKHWLLLLGICCPKPHGRVSSRLRLSRSLGHFFHSAFATFMGVCDKR
FT VGSIF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_055940"
FT VAR_SEQ 148..818
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_055941"
FT VARIANT 7
FT /note="R -> Q (in dbSNP:rs329709)"
FT /id="VAR_057400"
FT VARIANT 82
FT /note="P -> R (in dbSNP:rs8105668)"
FT /evidence="ECO:0000269|PubMed:10997877,
FT ECO:0000269|PubMed:11410164"
FT /id="VAR_060274"
SQ SEQUENCE 818 AA; 94112 MW; 00C5BE5E3E74B76B CRC64;
MALTQVRLTF RDVAIEFSQE EWKCLDPAQR ILYRDVMLEN YWNLVSLGLC HFDMNIISML
EEGKEPWTVK SCVKIARKPR TPECVKGVVT DIPPKCTIKD LLPKEKSSTE AVFHTVVLER
HESPDIEDFS FKEPQKNVHD FECQWRDDTG NYKGVLMAQK EGKRDQRDRR DIENKLMNNQ
LGVSFHSHLP ELQLFQGEGK MYECNQVEKS TNNGSSVSPL QQIPSSVQTH RSKKYHELNH
FSLLTQRRKA NSCGKPYKCN ECGKAFTQNS NLTSHRRIHS GEKPYKCSEC GKTFTVRSNL
TIHQVIHTGE KPYKCHECGK VFRHNSYLAT HRRIHTGEKP YKCNECGKAF RGHSNLTTHQ
LIHTGEKPFK CNECGKLFTQ NSHLISHWRI HTGEKPYKCN ECGKAFSVRS SLAIHQTIHT
GEKPYKCNEC GKVFRYNSYL GRHRRVHTGE KPYKCNECGK AFSMHSNLAT HQVIHTGTKP
FKCNECSKVF TQNSQLANHR RIHTGEKPYK CNECGKAFSV RSSLTTHQAI HSGEKPYKCI
ECGKSFTQKS HLRSHRGIHS GEKPYKCNEC GKVFAQTSQL ARHWRVHTGE KPYKCNDCGR
AFSDRSSLTF HQAIHTGEKP YKCHECGKVF RHNSYLATHR RIHTGEKPYK CNECGKAFSM
HSNLTTHKVI HTGEKPYKCN QCGKVFTQNS HLANHQRTHT GEKPYRCNEC GKAFSVRSSL
TTHQAIHTGK KPYKCNECGK VFTQNAHLAN HRRIHTGEKP YRCTECGKAF RVRSSLTTHM
AIHTGEKRYK CNECGKVFRQ SSNLASHHRM HTGEKPYK
