ZN169_HUMAN
ID ZN169_HUMAN Reviewed; 603 AA.
AC Q14929; A2AGP5; A8K127; Q6PI28;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 3.
DT 03-AUG-2022, entry version 189.
DE RecName: Full=Zinc finger protein 169;
GN Name=ZNF169;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 91-603, AND VARIANT HIS-596.
RX PubMed=9071574;
RX DOI=10.1002/(sici)1098-2264(199703)18:3<212::aid-gcc7>3.0.co;2-4;
RA Chidambaram A., Gailani M., Gerrard B., Stewart C., Goldstein A.,
RA Chumakov I., Bale A.E., Dean M.;
RT "Characterization of a YAC contig containing the NBCCS locus and a novel
RT Kruppel-type zinc finger sequence on chromosome segment 9q22.3.";
RL Genes Chromosomes Cancer 18:212-218(1997).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q14929; Q9NP86: CABP5; NbExp=3; IntAct=EBI-10234472, EBI-10311131;
CC Q14929; O95273: CCNDBP1; NbExp=3; IntAct=EBI-10234472, EBI-748961;
CC Q14929; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-10234472, EBI-739624;
CC Q14929; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-10234472, EBI-12012928;
CC Q14929; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10234472, EBI-10172290;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Highly expressed in kidney, weakly expressed in
CC heart, liver, spleen, and small intestine. Not expressed in adult brain
CC or spinal cord.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH47702.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAF82431.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK289742; BAF82431.1; ALT_INIT; mRNA.
DR EMBL; AL691447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471089; EAW62879.1; -; Genomic_DNA.
DR EMBL; BC047702; AAH47702.1; ALT_INIT; mRNA.
DR EMBL; U28251; AAA70188.1; -; Genomic_DNA.
DR CCDS; CCDS6709.2; -.
DR RefSeq; NP_919301.2; NM_194320.3.
DR RefSeq; XP_016869853.1; XM_017014364.1.
DR AlphaFoldDB; Q14929; -.
DR SMR; Q14929; -.
DR BioGRID; 127990; 52.
DR IntAct; Q14929; 48.
DR STRING; 9606.ENSP00000378792; -.
DR GlyGen; Q14929; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q14929; -.
DR PhosphoSitePlus; Q14929; -.
DR BioMuta; ZNF169; -.
DR DMDM; 259016472; -.
DR MassIVE; Q14929; -.
DR PaxDb; Q14929; -.
DR PeptideAtlas; Q14929; -.
DR PRIDE; Q14929; -.
DR ProteomicsDB; 60222; -.
DR Antibodypedia; 28458; 165 antibodies from 27 providers.
DR DNASU; 169841; -.
DR Ensembl; ENST00000395395.7; ENSP00000378792.2; ENSG00000175787.17.
DR GeneID; 169841; -.
DR KEGG; hsa:169841; -.
DR MANE-Select; ENST00000395395.7; ENSP00000378792.2; NM_194320.4; NP_919301.2.
DR UCSC; uc004aum.2; human.
DR CTD; 169841; -.
DR DisGeNET; 169841; -.
DR GeneCards; ZNF169; -.
DR HGNC; HGNC:12957; ZNF169.
DR HPA; ENSG00000175787; Low tissue specificity.
DR MIM; 603404; gene.
DR neXtProt; NX_Q14929; -.
DR OpenTargets; ENSG00000175787; -.
DR PharmGKB; PA37539; -.
DR VEuPathDB; HostDB:ENSG00000175787; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163169; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q14929; -.
DR OMA; YRVCEQG; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q14929; -.
DR TreeFam; TF338096; -.
DR PathwayCommons; Q14929; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q14929; -.
DR BioGRID-ORCS; 169841; 36 hits in 1094 CRISPR screens.
DR ChiTaRS; ZNF169; human.
DR GenomeRNAi; 169841; -.
DR Pharos; Q14929; Tdark.
DR PRO; PR:Q14929; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q14929; protein.
DR Bgee; ENSG00000175787; Expressed in parotid gland and 154 other tissues.
DR ExpressionAtlas; Q14929; baseline and differential.
DR Genevisible; Q14929; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..603
FT /note="Zinc finger protein 169"
FT /id="PRO_0000047438"
FT DOMAIN 14..85
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 234..256
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 262..284
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 290..312
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 318..340
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 346..368
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 374..396
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 402..424
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 430..452
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 458..480
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 486..508
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 514..536
FT /note="C2H2-type 11; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 542..564
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 570..592
FT /note="C2H2-type 13; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 121..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..157
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 72
FT /note="P -> L (in dbSNP:rs1536690)"
FT /id="VAR_024198"
FT VARIANT 78
FT /note="E -> K (in dbSNP:rs35177967)"
FT /id="VAR_059065"
FT VARIANT 152
FT /note="S -> L (in dbSNP:rs34433105)"
FT /id="VAR_059066"
FT VARIANT 381
FT /note="R -> C (in dbSNP:rs12236219)"
FT /id="VAR_024199"
FT VARIANT 596
FT /note="Q -> H (in dbSNP:rs12350212)"
FT /evidence="ECO:0000269|PubMed:9071574"
FT /id="VAR_059067"
FT CONFLICT 91..99
FT /note="FQPSFPHLV -> IPAKFSPPG (in Ref. 5; AAA70188)"
FT /evidence="ECO:0000305"
FT CONFLICT 276..278
FT /note="SLS -> PSP (in Ref. 5; AAA70188)"
FT /evidence="ECO:0000305"
FT CONFLICT 343
FT /note="E -> D (in Ref. 1; BAF82431)"
FT /evidence="ECO:0000305"
FT CONFLICT 349..356
FT /note="PECGRGFC -> LSVGEAL (in Ref. 5; AAA70188)"
FT /evidence="ECO:0000305"
FT CONFLICT 376
FT /note="C -> S (in Ref. 5; AAA70188)"
FT /evidence="ECO:0000305"
FT CONFLICT 382
FT /note="S -> T (in Ref. 5; AAA70188)"
FT /evidence="ECO:0000305"
FT CONFLICT 470..471
FT /note="KV -> NG (in Ref. 5; AAA70188)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 603 AA; 68488 MW; E50538A48E248AB9 CRC64;
MSPGLLTTRK EALMAFRDVA VAFTQKEWKL LSSAQRTLYR EVMLENYSHL VSLGIAFSKP
KLIEQLEQGD EPWREENEHL LDLCPEPRTE FQPSFPHLVA FSSSQLLRQY ALSGHPTQIF
PSSSAGGDFQ LEAPRCSSEK GESGETEGPD SSLRKRPSRI SRTFFSPHQG DPVEWVEGNR
EGGTDLRLAQ RMSLGGSDTM LKGADTSESG AVIRGNYRLG LSKKSSLFSH QKHHVCPECG
RGFCQRSDLI KHQRTHTGEK PYLCPECGRR FSQKASLSIH QRKHSGEKPY VCRECGRHFR
YTSSLTNHKR IHSGERPFVC QECGRGFRQK IALLLHQRTH LEEKPFVCPE CGRGFCQKAS
LLQHQSSHTG ERPFLCLECG RSFRQQSLLL SHQVTHSGEK PYVCAECGHS FRQKVTLIRH
QRTHTGEKPY LCPQCGRGFS QKVTLIGHQR THTGEKPYLC PDCGRGFGQK VTLIRHQRTH
TGEKPYLCPK CGRAFGFKSL LTRHQRTHSE EELYVDRVCG QGLGQKSHLI SDQRTHSGEK
PCICDECGRG FGFKSALIRH QRTHSGEKPY VCRECGRGFS QKSHLHRHRR TKSGHQLLPQ
EVF
