ZN16L_DANRE
ID ZN16L_DANRE Reviewed; 528 AA.
AC A0A1D5NS60; A0A1D5NSY2;
DT 12-SEP-2018, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2016, sequence version 1.
DT 03-AUG-2022, entry version 37.
DE RecName: Full=Zinc finger protein 16-like {ECO:0000303|PubMed:26459222};
DE AltName: Full=Zinc finger protein 697-like {ECO:0000303|PubMed:26459222};
GN Name=znf16l {ECO:0000303|PubMed:26459222};
GN Synonyms=znf697l {ECO:0000303|PubMed:26459222};
GN ORFNames=si:ch211-108m2.2 {ECO:0000312|ZFIN:ZDB-GENE-160728-135};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000312|Proteomes:UP000000437};
RN [1] {ECO:0000312|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000305}
RP FUNCTION, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF CYS-428.
RX PubMed=26459222; DOI=10.1242/dev.128215;
RA Sidik H., Talbot W.S.;
RT "A zinc finger protein that regulates oligodendrocyte specification,
RT migration and myelination in zebrafish.";
RL Development 142:4119-4128(2015).
CC -!- FUNCTION: Probable transcription factor (Probable). Important for
CC development and migration of oligodendrocyte precursor cells, and
CC normal myelination of axons in the central nervous system (CNS)
CC (PubMed:26459222). Functions autonomously in oligodendrocytes to
CC promote CNS myelination (PubMed:26459222). Seems to act in parallel
CC with notch3 during oligodendrocyte development (PubMed:26459222).
CC {ECO:0000269|PubMed:26459222, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A0A1D5NS60-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A0A1D5NS60-2; Sequence=VSP_059729;
CC -!- DISRUPTION PHENOTYPE: Gross morphology is normal. Expression of myelin
CC basic protein (mbp) in the central nervous system at 5 dpf is strongly
CC reduced. Expression of mpb in the peripheral nervous system is normal.
CC {ECO:0000269|PubMed:26459222}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; BX324198; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_699131.3; XM_694039.7. [A0A1D5NS60-2]
DR AlphaFoldDB; A0A1D5NS60; -.
DR SMR; A0A1D5NS60; -.
DR STRING; 7955.ENSDARP00000108517; -.
DR Ensembl; ENSDART00000173638; ENSDARP00000142669; ENSDARG00000105532. [A0A1D5NS60-1]
DR Ensembl; ENSDART00000173929; ENSDARP00000142953; ENSDARG00000105532. [A0A1D5NS60-2]
DR GeneID; 570544; -.
DR KEGG; dre:570544; -.
DR CTD; 570544; -.
DR ZFIN; ZDB-GENE-160728-135; znf16l.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT01050000244859; -.
DR OMA; RIYDYEW; -.
DR OrthoDB; 1318335at2759; -.
DR PRO; PR:A0A1D5NS60; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 7.
DR Bgee; ENSDARG00000105532; Expressed in mature ovarian follicle and 19 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0022010; P:central nervous system myelination; IMP:UniProtKB.
DR GO; GO:0031643; P:positive regulation of myelination; IMP:UniProtKB.
DR GO; GO:0048714; P:positive regulation of oligodendrocyte differentiation; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Metal-binding; Neurogenesis; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..528
FT /note="Zinc finger protein 16-like"
FT /id="PRO_0000445020"
FT ZN_FING 303..326
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 366..388
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 394..416
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 423..445
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 451..473
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 479..501
FT /note="C2H2-type 6; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 502..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 79..106
FT /evidence="ECO:0000255"
FT COMPBIAS 9..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 523..528
FT /note="Missing (in isoform 2)"
FT /id="VSP_059729"
FT MUTAGEN 428
FT /note="C->F: In st78; gross morphology is normal.
FT Expression of myelin basic protein (mbp) in the central
FT nervous system (CNS) is strongly reduced, whereas mbp
FT expression in the peripheral nervous system is unaffected.
FT Expression of sox10 and olig2 in oligodendrocyte precursor
FT cells (OPCs) is significantly reduced. Migration of OPCs is
FT impaired with delayed onset and aberrant pathfinding
FT behavior. Myelination in the CNS is reduced at 5 and 9 days
FT post-fertilization. Double knockouts with notch3 have a
FT more severe phenotype."
FT /evidence="ECO:0000269|PubMed:26459222"
SQ SEQUENCE 528 AA; 58861 MW; 5AA1B7E6FE8429D3 CRC64;
MSRKRNHCYM ETGASSESQG AFVDSAGPFS RDEEDFSELE PDEQLVCSVT EITEHLGRNI
TVVLESALSE IRKLVGVRIR VLKMELREKS DEIELLKAKL ESAEKDGRVS NFSSLDFRKS
EHQKYGAEPK KAKTGTPVVK KENINAICDY LMKDKNQRGA AEVESDHSNQ AFGSERDVRT
EAQPHGSLSL WPDSGPADTD AETDIFSMLP SASKRMYDYE WMTGVELNSA EFKGDSETKC
EDVPPMDEED ENEDSEEGRG SLRSVSDHFP LDTQGSPGED RSSPAEDSMD RMEPGQQFTS
HTFICPFCGT LCPDSSFLEE HIKLMHHGES LLQSTSAGSS SQAEGDSGEA GPASRGAREK
KVEGGYECGD CGRHFNYLGN LRQHQRIHTG EKPFVCPECG ERFRHTARLK SHRLSHSGAQ
SPFPCPQCGK GFPVLSGLKR HQRVHTGESP YACPQCGRRF KELGNLYTHM RIHSGATPYT
CYQCGRSFRH LGTYKSHRCM PATQMPSEHS PPWAQEDKVQ TGRLQGYV
