ZN177_HUMAN
ID ZN177_HUMAN Reviewed; 481 AA.
AC Q13360; B4DY57; E9PDG0; I3L0I4; Q96ER2;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2012, sequence version 4.
DT 03-AUG-2022, entry version 191.
DE RecName: Full=Zinc finger protein 177;
GN Name=ZNF177;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANTS MET-112 AND PHE-455.
RX PubMed=8661005; DOI=10.1006/geno.1996.0221;
RA Baban S., Freeman J.D., Mager D.L.;
RT "Transcripts from a novel human KRAB zinc finger gene contain spliced Alu
RT and endogenous retroviral segments.";
RL Genomics 33:463-472(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), AND VARIANT MET-112.
RX PubMed=11549323; DOI=10.1006/geno.2001.6604;
RA Landry J.R., Medstrand P., Mager D.L.;
RT "Repetitive elements in the 5' untranslated region of a human zinc-finger
RT gene modulate transcription and translation efficiency.";
RL Genomics 76:110-116(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS MET-112
RP AND PHE-455.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q13360; J3JSM9: ARHGAP21; NbExp=3; IntAct=EBI-3921570, EBI-10178656;
CC Q13360-2; A0A087WZT3: BOLA2B; NbExp=3; IntAct=EBI-12272076, EBI-12006120;
CC Q13360-2; Q96Q77: CIB3; NbExp=3; IntAct=EBI-12272076, EBI-10292696;
CC Q13360-2; P68400: CSNK2A1; NbExp=3; IntAct=EBI-12272076, EBI-347804;
CC Q13360-2; Q8WUE5: CT55; NbExp=3; IntAct=EBI-12272076, EBI-6873363;
CC Q13360-2; Q8IYI6: EXOC8; NbExp=3; IntAct=EBI-12272076, EBI-742102;
CC Q13360-2; P25800: LMO1; NbExp=3; IntAct=EBI-12272076, EBI-8639312;
CC Q13360-2; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-12272076, EBI-10172526;
CC Q13360-2; P40692: MLH1; NbExp=3; IntAct=EBI-12272076, EBI-744248;
CC Q13360-2; Q15126: PMVK; NbExp=3; IntAct=EBI-12272076, EBI-1055562;
CC Q13360-2; O43741: PRKAB2; NbExp=3; IntAct=EBI-12272076, EBI-1053424;
CC Q13360-2; P31321: PRKAR1B; NbExp=3; IntAct=EBI-12272076, EBI-2805516;
CC Q13360-2; P20618: PSMB1; NbExp=3; IntAct=EBI-12272076, EBI-372273;
CC Q13360-2; P60880-2: SNAP25; NbExp=3; IntAct=EBI-12272076, EBI-12177361;
CC Q13360-2; O75971-2: SNAPC5; NbExp=3; IntAct=EBI-12272076, EBI-12004298;
CC Q13360-2; Q9BUZ4: TRAF4; NbExp=3; IntAct=EBI-12272076, EBI-3650647;
CC Q13360-2; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-12272076, EBI-10183064;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q13360-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q13360-2; Sequence=VSP_044461;
CC Name=3;
CC IsoId=Q13360-3; Sequence=VSP_045841, VSP_045842;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; U37263; AAB09749.1; -; mRNA.
DR EMBL; U37251; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK302274; BAG63619.1; -; mRNA.
DR EMBL; AC011451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC012012; AAH12012.1; -; mRNA.
DR CCDS; CCDS12212.1; -. [Q13360-2]
DR CCDS; CCDS54214.1; -. [Q13360-1]
DR CCDS; CCDS56081.1; -. [Q13360-3]
DR RefSeq; NP_001166121.1; NM_001172650.2. [Q13360-2]
DR RefSeq; NP_001166122.1; NM_001172651.1. [Q13360-1]
DR RefSeq; NP_001189354.1; NM_001202425.1. [Q13360-3]
DR RefSeq; NP_003442.2; NM_003451.2. [Q13360-2]
DR AlphaFoldDB; Q13360; -.
DR SMR; Q13360; -.
DR BioGRID; 113519; 24.
DR BioGRID; 1529384; 17.
DR IntAct; Q13360; 21.
DR MINT; Q13360; -.
DR STRING; 9606.ENSP00000415070; -.
DR iPTMnet; Q13360; -.
DR PhosphoSitePlus; Q13360; -.
DR BioMuta; ZNF177; -.
DR DMDM; 425906076; -.
DR EPD; Q13360; -.
DR jPOST; Q13360; -.
DR MassIVE; Q13360; -.
DR MaxQB; Q13360; -.
DR PaxDb; Q13360; -.
DR PeptideAtlas; Q13360; -.
DR PRIDE; Q13360; -.
DR ProteomicsDB; 46361; -.
DR ProteomicsDB; 59343; -. [Q13360-1]
DR Antibodypedia; 828; 83 antibodies from 17 providers.
DR DNASU; 7730; -.
DR Ensembl; ENST00000343499.8; ENSP00000341497.3; ENSG00000188629.13. [Q13360-2]
DR Ensembl; ENST00000589262.5; ENSP00000468531.1; ENSG00000188629.13. [Q13360-1]
DR GeneID; 100529215; -.
DR GeneID; 7730; -.
DR KEGG; hsa:100529215; -.
DR KEGG; hsa:7730; -.
DR MANE-Select; ENST00000683217.1; ENSP00000507083.1; NM_001172651.2; NP_001166122.1.
DR UCSC; uc002mlk.4; human. [Q13360-1]
DR CTD; 100529215; -.
DR CTD; 7730; -.
DR DisGeNET; 100529215; -.
DR DisGeNET; 7730; -.
DR GeneCards; ZNF177; -.
DR HGNC; HGNC:12966; ZNF177.
DR HPA; ENSG00000188629; Low tissue specificity.
DR MIM; 601276; gene.
DR neXtProt; NX_Q13360; -.
DR OpenTargets; ENSG00000188629; -.
DR OpenTargets; ENSG00000270011; -.
DR PharmGKB; PA37548; -.
DR VEuPathDB; HostDB:ENSG00000188629; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163463; -.
DR HOGENOM; CLU_002678_0_7_1; -.
DR InParanoid; Q13360; -.
DR OMA; HEYDQCD; -.
DR PhylomeDB; Q13360; -.
DR PathwayCommons; Q13360; -.
DR SignaLink; Q13360; -.
DR BioGRID-ORCS; 100529215; 15 hits in 962 CRISPR screens.
DR BioGRID-ORCS; 7730; 7 hits in 1067 CRISPR screens.
DR Pharos; Q13360; Tbio.
DR PRO; PR:Q13360; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q13360; protein.
DR Bgee; ENSG00000188629; Expressed in right uterine tube and 97 other tissues.
DR ExpressionAtlas; Q13360; baseline and differential.
DR Genevisible; Q13360; HS.
DR GO; GO:0072562; C:blood microparticle; HDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..481
FT /note="Zinc finger protein 177"
FT /id="PRO_0000047441"
FT DOMAIN 14..84
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 145..170
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 176..198
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 256..278
FT /note="C2H2-type 3; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 284..306
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 312..334
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 340..362
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 368..390
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 396..418
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 424..446
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 452..474
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 113..272
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:8661005"
FT /id="VSP_044461"
FT VAR_SEQ 113..120
FT /note="AENQPGEH -> NPHGREFL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:11549323"
FT /id="VSP_045841"
FT VAR_SEQ 121..481
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:11549323"
FT /id="VSP_045842"
FT VARIANT 94
FT /note="D -> G (in dbSNP:rs2230750)"
FT /id="VAR_031692"
FT VARIANT 112
FT /note="T -> M (in dbSNP:rs2217652)"
FT /evidence="ECO:0000269|PubMed:11549323,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:8661005"
FT /id="VAR_031693"
FT VARIANT 455
FT /note="I -> F (in dbSNP:rs2230752)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:8661005"
FT /id="VAR_057401"
FT CONFLICT 29
FT /note="A -> G (in Ref. 2; U37251)"
FT /evidence="ECO:0000305"
FT CONFLICT 470
FT /note="H -> P (in Ref. 5; AAH12012)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 481 AA; 54782 MW; ECC43A8D975F6F90 CRC64;
MAAGWLTTWS QNSVTFQEVA VDFSQEEWAL LDPAQKNLYK DVMLENFRNL ASVGYQLCRH
SLISKVDQEQ LKTDERGILQ GDCADWETQL KPKDTIAMQN IPGGKTSNGI NTAENQPGEH
SLECNHCGKF RKNTRFICTR YCKGEKCYKY IKYSKVFNHP STLRSHVSIH IGEKTLEFTD
CRKAFNQESS LRKHLRTPTG QKFQEYEQCD MSFSLHSSCS VREQIPTGEK GDECSDYGKI
SPLSVHTKTG SVEEGLECNE HEKTFTDPLS LQNCVRTHSG EMPYECSDCG KAFIFQSSLK
KHMRSHTGEK PYECDHCGKS FSQSSHLNVH KRTHTGEKPY DCKECGKAFT VPSSLQKHVR
THTGEKPYEC SDCGKAFIDQ SSLKKHTRSH TGEKPYECNQ CGKSFSTGSY LIVHKRTHTG
EKTYECKECG KAFRNSSCLR VHVRTHTGEK PYKCIQCEKA FSTSTNLIMH KRIHNGQKLH
E
