ID   ZN182_PONAB             Reviewed;         620 AA.
AC   Q5R9S5;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Zinc finger protein 182;
DE   AltName: Full=Zinc finger protein 21;
GN   Name=ZNF182; Synonyms=ZNF21;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; CR859307; CAH91485.1; -; mRNA.
DR   RefSeq; NP_001125874.1; NM_001132402.1.
DR   AlphaFoldDB; Q5R9S5; -.
DR   SMR; Q5R9S5; -.
DR   STRING; 9601.ENSPPYP00000022723; -.
DR   GeneID; 100172805; -.
DR   KEGG; pon:100172805; -.
DR   CTD; 7569; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   InParanoid; Q5R9S5; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 14.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 14.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 8.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..620
FT                   /note="Zinc finger protein 182"
FT                   /id="PRO_0000047347"
FT   DOMAIN          8..79
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         187..209
FT                   /note="C2H2-type 1; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         215..237
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         243..265
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         271..293
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         299..321
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         327..349
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         355..377
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         383..405
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         411..433
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         439..461
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         467..489
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         495..517
FT                   /note="C2H2-type 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         523..545
FT                   /note="C2H2-type 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         551..573
FT                   /note="C2H2-type 14"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         579..601
FT                   /note="C2H2-type 15"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          599..620
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   620 AA;  71479 MW;  EF59E5ACCBF1A80E CRC64;
     MAKPQGLVTF EDVAVDFTQE EWQYLNPPQR TLYRDVMLET YSNLVFVGQQ VTKPNLILKL
     EVEECPAEGK IPFWNFPEVC QVDEQIERQH QDDQDKCLLM QVGFSDKKTV TTKSACDCHE
     FGNILHLSTN LVASIQRPDK HESFGNNMED NLDLFSRSSA ENKYDNGCAK LFFHTEYEKT
     NLGVKPYGYK ECGKGLRRKK GLSLHQRIKN GEKPFECTAC RKTFSKKSHL IVHWRTHTGE
     KPFGCTECGK AFSQKSQLII HLRTHTGERP FECPECGKAF REKSTVIIHY RTHTGEKPHE
     CNECGKAFTQ KSNLIVHQKT HTGEKTYECT KCGESFIQKL DLIIHHSTHT GKKPHECNEC
     KKAFSDKSTL IIHQRTHTGE KPHKCTECGK SFNEKSTLIV HQRTHTGEKP YECDVCGKTF
     TQKSNLGVHQ RTHSGEKPFE CNECEKAFSQ KSYLMLHQRG HTGEKPYECN ECEKAFSQKS
     YLIIHQRTHT EEKPYKCNEC GKAFREKSKL IIHQRIHTGE KPYECPVCWK AFSQKSQLII
     HQRTHTGEKP YACTECGKAF REKSTFTVHQ RTHTGEKPYK CTECGKAFTQ KSNLIVHQRT
     HTGKKAHGRG HTRKSKFMAH