ZN185_HUMAN
ID ZN185_HUMAN Reviewed; 689 AA.
AC O15231; A4FTV3; A6NME5; B4DLE9; B7Z771; B8K2L9; B8K2M0; B8K2M1; B8K2M2;
AC E9PFR6; F5GXF7; F5GZL4; F8W8V7; H0Y4M8; O00345; Q8N1R8; Q9NSD2;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 3.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Zinc finger protein 185;
DE AltName: Full=LIM domain protein ZNF185;
DE AltName: Full=P1-A;
GN Name=ZNF185;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Blood;
RX PubMed=9268636; DOI=10.1006/geno.1997.4810;
RA Heiss N.S., Gloeckner G., Baechner D., Kioschis P., Klauck S.M.,
RA Hinzmann B., Rosenthal A., Herman G.E., Poustka A.;
RT "Genomic structure of a novel LIM domain gene (ZNF185) in Xq28 and
RT comparisons with the orthologous murine transcript.";
RL Genomics 43:329-338(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 4; 6; 7 AND 8), AND SUBCELLULAR
RP LOCATION.
RX PubMed=16799630; DOI=10.1038/sj.onc.1209769;
RA Zhang J.S., Gong A., Young C.Y.;
RT "ZNF185, an actin-cytoskeleton-associated growth inhibitory LIM protein in
RT prostate cancer.";
RL Oncogene 26:111-122(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 5 AND 9).
RC TISSUE=Synovium, and Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10854409; DOI=10.1101/gr.10.6.758;
RA Mallon A.-M., Platzer M., Bate R., Gloeckner G., Botcherby M.R.M.,
RA Nordsiek G., Strivens M.A., Kioschis P., Dangel A., Cunningham D.,
RA Straw R.N.A., Weston P., Gilbert M., Fernando S., Goodall K., Hunter G.,
RA Greystrong J.S., Clarke D., Kimberley C., Goerdes M., Blechschmidt K.,
RA Rump A., Hinzmann B., Mundy C.R., Miller W., Poustka A., Herman G.E.,
RA Rhodes M., Denny P., Rosenthal A., Brown S.D.M.;
RT "Comparative genome sequence analysis of the Bpa/Str region in mouse and
RT man.";
RL Genome Res. 10:758-775(2000).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Platelet;
RX PubMed=18088087; DOI=10.1021/pr0704130;
RA Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,
RA Schuetz C., Walter U., Gambaryan S., Sickmann A.;
RT "Phosphoproteome of resting human platelets.";
RL J. Proteome Res. 7:526-534(2008).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-447; SER-453 AND SER-465,
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66 (ISOFORM 2),
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206 (ISOFORM 3), AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: May be involved in the regulation of cellular proliferation
CC and/or differentiation.
CC -!- INTERACTION:
CC O15231; Q9BTE6-2: AARSD1; NbExp=3; IntAct=EBI-6874731, EBI-9357295;
CC O15231; Q9HC52: CBX8; NbExp=3; IntAct=EBI-6874731, EBI-712912;
CC O15231; Q8TAP6: CEP76; NbExp=3; IntAct=EBI-6874731, EBI-742887;
CC O15231; O75031: HSF2BP; NbExp=3; IntAct=EBI-6874731, EBI-7116203;
CC O15231; P25791-3: LMO2; NbExp=3; IntAct=EBI-6874731, EBI-11959475;
CC O15231; Q8WWB5: PIH1D2; NbExp=3; IntAct=EBI-6874731, EBI-10232538;
CC O15231; Q6ZRT6: PRR23B; NbExp=3; IntAct=EBI-6874731, EBI-12845180;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000269|PubMed:16799630}. Cell junction, focal adhesion
CC {ECO:0000269|PubMed:16799630}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=9;
CC Name=1;
CC IsoId=O15231-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O15231-2; Sequence=VSP_039898, VSP_039899, VSP_039900,
CC VSP_039901, VSP_039902;
CC Name=3;
CC IsoId=O15231-3; Sequence=VSP_039900;
CC Name=4;
CC IsoId=O15231-4; Sequence=VSP_043405;
CC Name=5;
CC IsoId=O15231-5; Sequence=VSP_045080, VSP_045081, VSP_043405;
CC Name=6;
CC IsoId=O15231-6; Sequence=VSP_047206;
CC Name=7;
CC IsoId=O15231-7; Sequence=VSP_047205;
CC Name=8;
CC IsoId=O15231-8; Sequence=VSP_047205, VSP_047206;
CC Name=9;
CC IsoId=O15231-9; Sequence=VSP_054773;
CC -!- TISSUE SPECIFICITY: Expressed in placenta, pancreas and kidney. Also
CC expressed in prostate, testis, ovary and blood.
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DR EMBL; AK095258; BAC04511.1; -; mRNA.
DR EMBL; AY997296; AAY54245.1; -; mRNA.
DR EMBL; DQ508022; ABF57657.1; -; mRNA.
DR EMBL; DQ508023; ABF57658.1; -; mRNA.
DR EMBL; DQ508024; ABF57659.1; -; mRNA.
DR EMBL; DQ508025; ABF57660.1; -; mRNA.
DR EMBL; DQ508026; ABF57661.1; -; mRNA.
DR EMBL; Y09538; CAA70733.1; -; mRNA.
DR EMBL; AK296967; BAG59511.1; -; mRNA.
DR EMBL; AK301530; BAH13507.1; -; mRNA.
DR EMBL; U82671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471172; EAW72895.1; -; Genomic_DNA.
DR CCDS; CCDS48184.1; -. [O15231-1]
DR CCDS; CCDS55528.1; -. [O15231-3]
DR CCDS; CCDS55529.1; -. [O15231-6]
DR CCDS; CCDS55530.1; -. [O15231-8]
DR CCDS; CCDS55531.1; -. [O15231-4]
DR CCDS; CCDS55532.1; -. [O15231-5]
DR CCDS; CCDS69832.1; -. [O15231-9]
DR RefSeq; NP_001171577.1; NM_001178106.1. [O15231-6]
DR RefSeq; NP_001171578.1; NM_001178107.1. [O15231-8]
DR RefSeq; NP_001171579.1; NM_001178108.1. [O15231-3]
DR RefSeq; NP_001171580.1; NM_001178109.1. [O15231-7]
DR RefSeq; NP_001171581.1; NM_001178110.1. [O15231-4]
DR RefSeq; NP_001171584.1; NM_001178113.1. [O15231-5]
DR RefSeq; NP_001171586.1; NM_001178115.1. [O15231-9]
DR RefSeq; NP_009081.2; NM_007150.3. [O15231-1]
DR RefSeq; XP_005274788.1; XM_005274731.2. [O15231-6]
DR RefSeq; XP_005274792.1; XM_005274735.2. [O15231-8]
DR RefSeq; XP_005274794.1; XM_005274737.2. [O15231-3]
DR RefSeq; XP_005274795.1; XM_005274738.2. [O15231-1]
DR RefSeq; XP_005274798.1; XM_005274741.2. [O15231-7]
DR RefSeq; XP_005274802.1; XM_005274745.2. [O15231-4]
DR AlphaFoldDB; O15231; -.
DR BioGRID; 113525; 52.
DR IntAct; O15231; 15.
DR MINT; O15231; -.
DR STRING; 9606.ENSP00000440847; -.
DR GlyGen; O15231; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; O15231; -.
DR PhosphoSitePlus; O15231; -.
DR BioMuta; ZNF185; -.
DR EPD; O15231; -.
DR jPOST; O15231; -.
DR MassIVE; O15231; -.
DR MaxQB; O15231; -.
DR PeptideAtlas; O15231; -.
DR PRIDE; O15231; -.
DR ProteomicsDB; 24410; -.
DR ProteomicsDB; 25065; -.
DR ProteomicsDB; 30212; -.
DR ProteomicsDB; 34782; -.
DR ProteomicsDB; 48523; -. [O15231-1]
DR ProteomicsDB; 48524; -. [O15231-2]
DR ProteomicsDB; 48525; -. [O15231-3]
DR ProteomicsDB; 48526; -. [O15231-4]
DR Antibodypedia; 614; 146 antibodies from 20 providers.
DR DNASU; 7739; -.
DR Ensembl; ENST00000318504.12; ENSP00000312782.7; ENSG00000147394.19. [O15231-4]
DR Ensembl; ENST00000318529.13; ENSP00000313919.8; ENSG00000147394.19. [O15231-5]
DR Ensembl; ENST00000370268.8; ENSP00000359291.4; ENSG00000147394.19. [O15231-1]
DR Ensembl; ENST00000449285.6; ENSP00000395228.2; ENSG00000147394.19. [O15231-3]
DR Ensembl; ENST00000454925.1; ENSP00000392984.2; ENSG00000147394.19. [O15231-9]
DR Ensembl; ENST00000535861.6; ENSP00000440847.1; ENSG00000147394.19. [O15231-6]
DR Ensembl; ENST00000539731.6; ENSP00000444367.1; ENSG00000147394.19. [O15231-8]
DR GeneID; 7739; -.
DR KEGG; hsa:7739; -.
DR UCSC; uc004fgw.5; human. [O15231-1]
DR CTD; 7739; -.
DR DisGeNET; 7739; -.
DR GeneCards; ZNF185; -.
DR HGNC; HGNC:12976; ZNF185.
DR HPA; ENSG00000147394; Tissue enhanced (epididymis, esophagus).
DR MIM; 300381; gene.
DR neXtProt; NX_O15231; -.
DR OpenTargets; ENSG00000147394; -.
DR PharmGKB; PA37558; -.
DR VEuPathDB; HostDB:ENSG00000147394; -.
DR eggNOG; KOG1704; Eukaryota.
DR GeneTree; ENSGT00530000063872; -.
DR HOGENOM; CLU_031517_0_0_1; -.
DR InParanoid; O15231; -.
DR OMA; YIHRDTI; -.
DR OrthoDB; 1419858at2759; -.
DR PhylomeDB; O15231; -.
DR TreeFam; TF335114; -.
DR PathwayCommons; O15231; -.
DR SignaLink; O15231; -.
DR BioGRID-ORCS; 7739; 15 hits in 699 CRISPR screens.
DR ChiTaRS; ZNF185; human.
DR GenomeRNAi; 7739; -.
DR Pharos; O15231; Tbio.
DR PRO; PR:O15231; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; O15231; protein.
DR Bgee; ENSG00000147394; Expressed in tongue squamous epithelium and 175 other tissues.
DR ExpressionAtlas; O15231; baseline and differential.
DR Genevisible; O15231; HS.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; TAS:ProtInc.
DR InterPro; IPR030637; ZNF185.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR15468:SF2; PTHR15468:SF2; 2.
DR SMART; SM00132; LIM; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell junction; Cytoplasm; Cytoskeleton; LIM domain;
KW Metal-binding; Phosphoprotein; Reference proteome; Zinc.
FT CHAIN 1..689
FT /note="Zinc finger protein 185"
FT /id="PRO_0000075911"
FT DOMAIN 627..689
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT REGION 1..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..54
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..327
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 153
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q62394"
FT MOD_RES 447
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 453
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 465
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..403
FT /note="MSISALGGRTKGKPLPPGEEERNNVLKQMKVRTTLKGDKSWITKQDESEGRT
FT IELPSGRSRATSFSSAGEVPKPRPPSTRAPTGYIIRGVFTKPIDSSSQPQQQFPKANGT
FT PKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVVPFS
FT SDEQKRRSEAASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSE
FT KSQDPPALARSTPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQIL
FT TPRAGLRLVAPDVEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSD
FT GNVGSGATGSRPEGLAAVDIGSERGSSSATSVSAVPADRKSNSTAAQEDAKADPKG ->
FT MAARDELGLGGDSLEAMPVPAARGRPRITNGPEELAAPSPA (in isoform 9)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054773"
FT VAR_SEQ 1..140
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9268636"
FT /id="VSP_039898"
FT VAR_SEQ 1..135
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045080"
FT VAR_SEQ 141..144
FT /note="YKKL -> MQRQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9268636"
FT /id="VSP_039899"
FT VAR_SEQ 177..205
FT /note="RSEAASGVLRRTAPREHSYVLSAAKKSTG -> SS (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045081"
FT VAR_SEQ 205
FT /note="G -> GS (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:9268636"
FT /id="VSP_039900"
FT VAR_SEQ 246..304
FT /note="Missing (in isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:16799630"
FT /id="VSP_043405"
FT VAR_SEQ 246..275
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9268636"
FT /id="VSP_039901"
FT VAR_SEQ 276..304
FT /note="Missing (in isoform 7 and isoform 8)"
FT /evidence="ECO:0000303|PubMed:16799630"
FT /id="VSP_047205"
FT VAR_SEQ 305..372
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9268636"
FT /id="VSP_039902"
FT VAR_SEQ 372
FT /note="G -> GRLCAAASFASFLEDQDGHSANSQSCKPRPAAI (in isoform 6
FT and isoform 8)"
FT /evidence="ECO:0000303|PubMed:16799630"
FT /id="VSP_047206"
FT CONFLICT 13
FT /note="K -> E (in Ref. 2; ABF57661)"
FT /evidence="ECO:0000305"
FT CONFLICT 132
FT /note="S -> F (in Ref. 2; ABF57661)"
FT /evidence="ECO:0000305"
FT CONFLICT 150
FT /note="R -> G (in Ref. 2; ABF57661)"
FT /evidence="ECO:0000305"
FT CONFLICT 236
FT /note="A -> V (in Ref. 3; BAH13507)"
FT /evidence="ECO:0000305"
FT CONFLICT 257
FT /note="A -> T (in Ref. 2; ABF57661)"
FT /evidence="ECO:0000305"
FT CONFLICT 326
FT /note="A -> S (in Ref. 3; BAH13507)"
FT /evidence="ECO:0000305"
FT CONFLICT 406
FT /note="A -> D (in Ref. 2; ABF57661)"
FT /evidence="ECO:0000305"
FT CONFLICT 408
FT /note="Y -> C (in Ref. 1; CAA70733)"
FT /evidence="ECO:0000305"
FT CONFLICT 414
FT /note="A -> P (in Ref. 2; ABF57657/AAY54245 and 1;
FT CAA70733)"
FT /evidence="ECO:0000305"
FT CONFLICT 488
FT /note="Q -> H (in Ref. 2; ABF57660)"
FT /evidence="ECO:0000305"
FT CONFLICT 492
FT /note="G -> R (in Ref. 1; CAA70733)"
FT /evidence="ECO:0000305"
FT CONFLICT 517
FT /note="Q -> R (in Ref. 3; BAC04511)"
FT /evidence="ECO:0000305"
FT CONFLICT 621
FT /note="S -> F (in Ref. 2; ABF57657/AAY54245)"
FT /evidence="ECO:0000305"
FT MOD_RES O15231-2:66
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES O15231-3:206
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
SQ SEQUENCE 689 AA; 73525 MW; 0CCA739701FE1423 CRC64;
MSISALGGRT KGKPLPPGEE ERNNVLKQMK VRTTLKGDKS WITKQDESEG RTIELPSGRS
RATSFSSAGE VPKPRPPSTR APTGYIIRGV FTKPIDSSSQ PQQQFPKANG TPKSAASLVR
TANAGPPRPS SSGYKMTTED YKKLAPYNIR RSSTSGDTEE EEEEEVVPFS SDEQKRRSEA
ASGVLRRTAP REHSYVLSAA KKSTGPTQET QAPFIAKRVE VVEEDGPSEK SQDPPALARS
TPGSNSADGG RTKASRAIWI ECLPSMPSPA GSQELSSRGE EIVRLQILTP RAGLRLVAPD
VEGMRSSPGN KDKEAPCSRE LQRDLAGEEA FRAPNTDAAR SSAQLSDGNV GSGATGSRPE
GLAAVDIGSE RGSSSATSVS AVPADRKSNS TAAQEDAKAD PKGALADYEG KDVATRVGEA
WQERPGAPRG GQGDPAVPAQ QPADPSTPER QSSPSGSEQL VRRESCGSSV LTDFEGKDVA
TKVGEAWQDR PGAPRGGQGD PAVPTQQPAD PSTPEQQNSP SGSEQFVRRE SCTSRVRSPS
SCMVTVTVTA TSEQPHIYIP APASELDSSS TTKGILFVKE YVNASEVSSG KPVSARYSNV
SSIEDSFAME KKPPCGSTPY SERTTGGICT YCNREIRDCP KITLEHLGIC CHEYCFKCGI
CSKPMGDLLD QIFIHRDTIH CGKCYEKLF
