ZN200_HUMAN
ID ZN200_HUMAN Reviewed; 395 AA.
AC P98182; D3DUB7; D3DUB8; O15361; Q5XKM5; Q7Z5V1;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 03-AUG-2022, entry version 185.
DE RecName: Full=Zinc finger protein 200;
GN Name=ZNF200; Synonyms=ZNFMF;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=9787081; DOI=10.1006/geno.1998.5430;
RA Deng Z., Centola M., Chen X., Sood R., Vedula A., Fischel-Ghodsian N.,
RA Kastner D.L.;
RT "Identification of two Kruppel-related zinc finger genes (ZNF200 and
RT ZNF210) from human chromosome 16p13.3.";
RL Genomics 53:97-103(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2).
RC TISSUE=Liver;
RX PubMed=9288094; DOI=10.1038/ng0997-25;
RA Bernot A., Clepet C., Dasilva C., Devaud C., Petit J.-L., Caloustian C.,
RA Cruaud C., Samson D., Pulcini F., Weissenbach J., Heilig R., Notanicola C.,
RA Domingo C., Rozenbaum M., Benchetrit E., Topaloglu R., Dewalle M.,
RA Dross C., Hadjari P., Dupont M., Demaille J.G., Touitou I., Smaoui N.,
RA Nedelec B., Mery J.-P., Chaabouni H., Delpech M., Grateau G.;
RT "A candidate gene for familial Mediterranean fever.";
RL Nat. Genet. 17:25-31(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Eye, Liver, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Could have a role in spermatogenesis.
CC -!- INTERACTION:
CC P98182; Q14192: FHL2; NbExp=3; IntAct=EBI-3913354, EBI-701903;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=P98182-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P98182-2; Sequence=VSP_036037;
CC Name=3;
CC IsoId=P98182-3; Sequence=VSP_046734;
CC -!- TISSUE SPECIFICITY: Highly expressed in testis, weakly expressed in
CC spleen, thymus, prostate, ovary, small intestine colon and peripheral
CC blood leukocytes.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC70008.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH54005.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF060866; AAC70008.1; ALT_INIT; mRNA.
DR EMBL; Y14443; CAA74795.1; -; mRNA.
DR EMBL; AJ003147; CAA05905.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85384.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85385.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85386.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85387.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85388.1; -; Genomic_DNA.
DR EMBL; BC012909; AAH12909.1; -; mRNA.
DR EMBL; BC032575; AAH32575.1; -; mRNA.
DR EMBL; BC054005; AAH54005.1; ALT_INIT; mRNA.
DR CCDS; CCDS10497.1; -. [P98182-1]
DR CCDS; CCDS42112.1; -. [P98182-2]
DR CCDS; CCDS45395.1; -. [P98182-3]
DR RefSeq; NP_001138918.1; NM_001145446.1. [P98182-3]
DR RefSeq; NP_001138919.1; NM_001145447.1. [P98182-3]
DR RefSeq; NP_001138920.1; NM_001145448.1. [P98182-3]
DR RefSeq; NP_003445.2; NM_003454.3. [P98182-1]
DR RefSeq; NP_932353.1; NM_198087.2. [P98182-2]
DR RefSeq; NP_932354.1; NM_198088.2. [P98182-1]
DR RefSeq; XP_005255613.1; XM_005255556.1. [P98182-1]
DR RefSeq; XP_006721003.1; XM_006720940.2.
DR RefSeq; XP_006721004.1; XM_006720941.2. [P98182-1]
DR RefSeq; XP_016879136.1; XM_017023647.1.
DR AlphaFoldDB; P98182; -.
DR SMR; P98182; -.
DR BioGRID; 113536; 12.
DR IntAct; P98182; 5.
DR MINT; P98182; -.
DR STRING; 9606.ENSP00000395723; -.
DR iPTMnet; P98182; -.
DR PhosphoSitePlus; P98182; -.
DR BioMuta; ZNF200; -.
DR DMDM; 218511971; -.
DR jPOST; P98182; -.
DR MassIVE; P98182; -.
DR MaxQB; P98182; -.
DR PaxDb; P98182; -.
DR PeptideAtlas; P98182; -.
DR PRIDE; P98182; -.
DR ProteomicsDB; 12764; -.
DR ProteomicsDB; 57817; -. [P98182-1]
DR ProteomicsDB; 57818; -. [P98182-2]
DR Antibodypedia; 10763; 207 antibodies from 19 providers.
DR DNASU; 7752; -.
DR Ensembl; ENST00000396868.7; ENSP00000380077.3; ENSG00000010539.12. [P98182-2]
DR Ensembl; ENST00000396870.8; ENSP00000380079.4; ENSG00000010539.12. [P98182-3]
DR Ensembl; ENST00000396871.8; ENSP00000380080.4; ENSG00000010539.12. [P98182-3]
DR Ensembl; ENST00000414144.7; ENSP00000405786.2; ENSG00000010539.12. [P98182-1]
DR Ensembl; ENST00000431561.7; ENSP00000395723.3; ENSG00000010539.12. [P98182-1]
DR Ensembl; ENST00000575948.1; ENSP00000458508.1; ENSG00000010539.12. [P98182-3]
DR GeneID; 7752; -.
DR KEGG; hsa:7752; -.
DR MANE-Select; ENST00000414144.7; ENSP00000405786.2; NM_198088.3; NP_932354.1.
DR UCSC; uc002cui.3; human. [P98182-1]
DR CTD; 7752; -.
DR GeneCards; ZNF200; -.
DR HGNC; HGNC:12993; ZNF200.
DR HPA; ENSG00000010539; Tissue enhanced (testis).
DR MIM; 603231; gene.
DR neXtProt; NX_P98182; -.
DR OpenTargets; ENSG00000010539; -.
DR PharmGKB; PA37573; -.
DR VEuPathDB; HostDB:ENSG00000010539; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162595; -.
DR HOGENOM; CLU_058938_0_0_1; -.
DR InParanoid; P98182; -.
DR OMA; CNENKED; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P98182; -.
DR TreeFam; TF342316; -.
DR PathwayCommons; P98182; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; P98182; -.
DR BioGRID-ORCS; 7752; 11 hits in 1104 CRISPR screens.
DR GenomeRNAi; 7752; -.
DR Pharos; P98182; Tdark.
DR PRO; PR:P98182; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; P98182; protein.
DR Bgee; ENSG00000010539; Expressed in secondary oocyte and 156 other tissues.
DR ExpressionAtlas; P98182; baseline and differential.
DR Genevisible; P98182; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 1: Evidence at protein level;
KW Alternative splicing; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..395
FT /note="Zinc finger protein 200"
FT /id="PRO_0000047449"
FT ZN_FING 252..274
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 280..302
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 308..330
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 336..358
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 364..386
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 157..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..187
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 114
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9288094"
FT /id="VSP_036037"
FT VAR_SEQ 156
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_046734"
FT VARIANT 140
FT /note="T -> M (in dbSNP:rs9302870)"
FT /id="VAR_052790"
SQ SEQUENCE 395 AA; 45534 MW; 6E0B8FC5702A159A CRC64;
MMAAKVVPMP PKPKQSFILR VPPDSKLGQD LLRDATNGPK TIHQLVLEHF LTFLPKPSLV
QPSQKVKETL VIMKDVSSSL QNRVHPRPLV KLLPKGVQKE QETVSLYLKA NPEELVVFED
LNVFHCQEEC VSLDPTQQLT SEKEDDSSVG EMMLLAVNGS NPEGEDPERE PVENEDYREK
SSDDDEMDSS LVSQQPPDNQ EKERLNTSIP QKRKMRNLLV TIENDTPLEE LSKYVDISII
ALTRNRRTRR WYTCPLCGKQ FNESSYLISH QRTHTGEKPY DCNHCGKSFN HKTNLNKHER
IHTGEKPYSC SQCGKNFRQN SHRSRHEGIH IREKIFKCPE CGKTFPKNEE FVLHLQSHEA
ERPYGCKKCG RRFGRLSNCT RHEKTHSACK TRKQK
